Protein Information

Name integrin
Synonyms Alpha 11 precursor; HsT18964; ITGA11; Integrin; Integrin alpha 11; Integrin alpha 11 precursor; MSTP018; HsT18964s…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
15537746 Yancy SL, Shelden EA, Gilmont RR, Welsh MJ: Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts. Toxicol Sci. 2005 Apr;84(2):278-86. Epub 2004 Nov 10.

Our results indicate that sodium arsenite can alter focal adhesion structure and function, thus affecting cell attachment and migration and possibly other aspects of focal adhesion function such as integrin signaling.
81(1,1,1,1) Details
19083458 Pai MH, Chien YW, Tsai YH, Hu YM, Yeh SL: Glutamine reduces the expression of leukocyte integrins leukocyte function-associated antigen-1 and macrophage antigen-1 in mice exposed to arsenic. Nutr Res. 2008 Aug;28(8):544-9.

The control group drank deionized water, whereas the experimental group drank deionized water containing 50 ppm of sodium arsenite.
4(0,0,0,4) Details
17158527 Mousa SA, O'Connor L, Rossman TG, Block E: Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds. Carcinogenesis. 2007 May;28(5):962-7. Epub 2006 Dec 8.

These data suggest that the pro-angiogenesis effect of arsenic is initiated at the plasma membrane integrin alphavbeta3, involves activation of the ERK1/2 pathway and is effectively reversed by various selenium-derived compounds.
The pro-angiogenesis effects and mechanisms of sodium arsenite were determined using the chick chorioallantoic membrane (CAM) model over 3 days and compared with standard pro-angiogenesis factors, such as basic fibroblast growth factor (b-FGF).
1(0,0,0,1) Details
16054901 Patterson TJ, Reznikova TV, Phillips MA, Rice RH: Arsenite maintains germinative state in cultured human epidermal cells. Toxicol Appl Pharmacol. 2005 Aug 22;207(1):69-77. Epub 2005 Jan 25.

In the present study, low micromolar concentrations of sodium arsenite maintained the proliferative potential of epidermal keratinocytes, decreasing their exit from the germinative compartment under conditions that promote differentiation of untreated cells.
Arsenite-treated cultures exhibited elevated levels of beta1-integrin and beta-catenin, two proteins enriched in cells with high proliferative potential.
1(0,0,0,1) Details