| Name | ERK1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11322385 | Chen YC, Tsai SH, Shen SC, Lin JK, Lee WR: Alternative activation of extracellular signal-regulated protein kinases in and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. Eur J Cell Biol. 2001 Mar;80(3):213-21. Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl- (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression. |
162(2,2,2,2) | Details |
| 17158527 | Mousa SA, O'Connor L, Rossman TG, Block E: Pro-angiogenesis action of arsenic and its reversal by -derived compounds. Carcinogenesis. 2007 May;28(5):962-7. Epub 2006 Dec 8. The pro-angiogenesis effect of either sodium arsenite at 33 nM or b-FGF was blocked (P < 0.01) by the extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation inhibitor, PD 98059. |
81(1,1,1,1) | Details |
| 19577553 | Huang YC, Hung WC, Chen WT, Yu HS, Chai CY: Sodium arsenite-induced DAPK promoter hypermethylation and autophagy via ERK1/2 phosphorylation in human uroepithelial cells. Chem Biol Interact. 2009 Oct 7;181(2):254-62. Epub 2009 Jul 3. |
32(0,1,1,2) | Details |
| 11312036 | Son MH, Kang KW, Lee CH, Kim SG: Potentiation of arsenic-induced cytotoxicity by amino acid deprivation (SAAD) through activation of ERK1/2, p38 kinase and JNK1: the distinct role of JNK1 in SAAD-potentiated mercury toxicity. Toxicol Lett. 2001 Apr 8;121(1):45-55. Viability was assessed in H4IIE cells treated with sodium arsenite, mercuric selenite, lead trioxide or |
4(0,0,0,4) | Details |
| 11325585 | Chevalier D, Thorin E, Allen BG: Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells. J Pharmacol Toxicol Methods. 2000 Sep-Oct;44(2):429-39. Activation of the mitogen-activated protein kinase (MAP kinase) pathways in cultured porcine aortic vascular smooth muscle cells (VSMCs) was determined following a 5-min stimulation with endothelin-1 (ET-1), phorbol 12- 13- (PMA), H2O2, or sodium arsenite. Extracellular signal-related kinase (ERK1/2), p38, and c-Jun N-terminal kinase (JNK1/2) MAP kinase activation was assessed using anti-phospho-MAPK kinase antibodies. |
3(0,0,0,3) | Details |
| 7768904 | Trigon S, Morange M: Different carboxyl-terminal domain kinase activities are induced by heat-shock and arsenite. J Biol Chem. 1995 Jun 2;270(22):13091-8. We have previously shown that in HeLa cells a protein kinase (HS-CTD kinase) activity is induced rapidly after a heat or sodium arsenite shock. Mono Q chromatography allows the separation of five stress-induced CTD kinase activities, two of which coelute with active mitogen-activated protein kinase forms revealed by Western blotting with anti ERK1-ERK2 antibodies. |
2(0,0,0,2) | Details |
| 19429265 | Das J, Ghosh J, Manna P, Sinha M, Sil PC: protects rat testes against NaAsO (2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett. 2009 Jun 22;187(3):201-10. Epub 2009 Mar 14. Oral administration of (at a dose of 100mg/kg body weight for 5 days) was found to be effective in counteracting As-induced oxidative stress, attenuation of testicular damages and amelioration of apoptosis in testicular tissue by controlling the reciprocal regulation of Bcl-2/Bad, phospho-ERK1/2, phospho-p38, phospho-Akt and NF-kappaB. |
1(0,0,0,1) | Details |
| 15849723 | Felix K, Manna SK, Wise K, Barr J, Ramesh GT: Low levels of arsenite activates nuclear factor-kappaB and activator protein-1 in immortalized mesencephalic cells. J Biochem Mol Toxicol. 2005 Mar-Apr;19(2):67-77. In addition, arsenite was shown to induce phosphorylation of extracellular signal regulated kinase (ERK) 1/2 at concentrations of 1 microM and above. These mesencephalic cells were treated with low concentrations of sodium arsenite (0.1, 0.5, 1, 5, and 10 microM) and incubated for different periods of time (0-4 h). |
1(0,0,0,1) | Details |
| 7923353 | Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR: A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 1994 Sep 23;78(6):1027-37. MAPK-activated protein kinase-2 (MAPKAP kinase-2) is activated in vitro by the p42 and p44 isoforms of MAPK (p42/p44MAPK). In several cell lines, however, MAPKAP kinase-2 is activated by sodium arsenite, heat shock, or osmotic stress and not by agonists that activate p42/p44MAPK. |
1(0,0,0,1) | Details |
| 12472888 | Fauconneau B, Petegnief V, Sanfeliu C, Piriou A, Planas AM: Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of peroxide-induced cell death. J Neurochem. 2002 Dec;83(6):1338-48. Pre-treatment with arsenite increased protein kinase B (Akt) and extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation after H2O2. |
1(0,0,0,1) | Details |
| 11160250 | Chakravortty D, Kato Y, Sugiyama T, Koide N, Mu MM, Yoshida T, Yokochi T: The inhibitory action of sodium arsenite on lipopolysaccharide-induced production in RAW 267.4 macrophage cells: a role of Raf-1 in lipopolysaccharide signaling. J Immunol. 2001 Feb 1;166(3):2011-7. |
0(0,0,0,0) | Details |