| Name | multidrug resistance protein 1 |
|---|---|
| Synonyms | ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10814809 | Eufemia NA, Epel D: Induction of the multixenobiotic defense mechanism (MXR), P-glycoprotein, in the mussel Mytilus californianus as a general cellular response to environmental stresses. Aquat Toxicol. 2000 May 1;49(1-2):89-100. In this study, we report on the specificity of the induction of the transporter by various chemical and physical stressors. p-gp substrates (including the pesticides pentachlorophenol and chlorthal) as well as non-substrates (including DDE and sodium arsenite) induced p-gp activity and protein titer in the gill tissues of the mussel Mytilus californianus. |
85(1,1,1,5) | Details |
| 1967174 | Chin KV, Tanaka S, Darlington G, Pastan I, Gottesman MM: Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. J Biol Chem. 1990 Jan 5;265(1):221-6. The levels of the multidrug transporter, P-glycoprotein, as measured by immunoprecipitation, were also increased after heat shock and sodium arsenite treatment. |
42(0,1,2,7) | Details |
| 1360409 | Kioka N, Yamano Y, Komano T, Ueda K: Heat-shock responsive elements in the induction of the multidrug resistance gene (MDR1). FEBS Lett. 1992 Apr 13;301(1):37-40. We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. |
9(0,0,1,4) | Details |
| 8556709 | Kim SH, Lee SH, Kwak NH, Kang CD, Chung BS: Effect of the activated Raf protein kinase on the human multidrug resistance 1 (MDR1) gene promoter. Cancer Lett. 1996 Jan 2;98(2):199-205. We observed that the activated Raf significantly potentiated the induction of MDRCAT activity in GHE-L cells by sodium arsenite or heat shock, which stimulates heat shock factor (HSF) binding to HSE. |
6(0,0,0,6) | Details |
| 9873828 | Kim SH, Yeo GS, Lim YS, Kang CD, Kim CM, Chung BS: Suppression of multidrug resistance via inhibition of heat shock factor by in MDR cells. Exp Mol Med. 1998 Jun 30;30(2):87-92. MDR1 promoter has been shown to contain heat shock elements (HSE), and it has been reported that FM3A/M and P388/M MDR cells show a constitutively activated heat shock factor (HSF), suggesting that HSF might be an important target for reversing the multidrug resistance. In this study, appeared to inhibit the constitutive HSF DNA-binding activity and the sodium arsenite-induced HSF DNA-binding activity in the MDR cells. |
3(0,0,0,3) | Details |
| 11750083 | Liu J, Liu Y, Powell DA, Waalkes MP, Klaassen CD: Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. Toxicology. 2002 Jan 15;170(1-2):55-62. Our recent work shows that acquired arsenic resistance is associated with overexpression of P-glycoprotein and can be reversed by PSC833, an inhibitor for P-glycoprotein. The mdr1a/1b (-/-) and wild-type FVB mice were given arsenic as sodium arsenite (12-19 mg/kg, sc) and toxicity was examined 24 h later. |
3(0,0,0,3) | Details |
| 8098523 | Grondin K, Papadopoulou B, Ouellette M: Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania. Nucleic Acids Res. 1993 Apr 25;21(8):1895-901. At least two loci derived from the same 800 kb chromosome were amplified either as extrachromosomal circles or linear fragments after sodium arsenite selection. |
3(0,0,0,3) | Details |
| 11278867 | Ito K, Olsen SL, Qiu W, Deeley RG, Cole SP: Mutation of a single conserved in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. J Biol Chem. 2001 May 11;276(19):15616-24. Epub 2001 Feb 21. In contrast, resistance to sodium arsenite was only partially diminished, and resistance to antimony remained comparable to that of cells expressing wild-type MRP1. |
2(0,0,0,2) | Details |
| 11408547 | Vernhet L, Seite MP, Allain N, Guillouzo A, Fardel O: Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes. J Pharmacol Exp Ther. 2001 Jul;298(1):234-9. Metals, such as arsenic or cadmium, have recently been demonstrated to interact with metabolic pathways, including phase I and phase II enzymes and the phase III efflux pump P-glycoprotein. Treatment of primary rat hepatocytes by sodium arsenite [As (III)], arsenate and antimony but not cadmium was shown to markedly increase MRP2 mRNA and protein levels; As (III)-mediated induction was dose- and time-dependent and paralleled a strong increase in MRP2 amounts as assessed by Western blotting. |
2(0,0,0,2) | Details |
| 7915598 | Venetianer A, Pirity M, Hever-Szabo A: The function of heat-shock proteins in stress tolerance. Cell Biol Int. 1994 Jun;18(6):605-15. Our experiments show that clone 2 cells were not protected from the killing effect of heat by pre-treatment with sodium arsenite, whereas Faza 967 cells were. The multidrug resistance of the hepatoma variants correlates with the overexpression of the plasma membrane P-glycoprotein. |
2(0,0,0,2) | Details |
| 11855834 | Lorico A, Bertola A, Baum C, Fodstad O, Rappa G: Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice. Biochem Biophys Res Commun. 2002 Mar 1;291(3):617-22. We have previously shown that mrp1 (-/-) cells are hypersensitive to sodium arsenite, arsenate, and antimony |
2(0,0,0,2) | Details |
| 8947035 | Broeks A, Gerrard B, Allikmets R, Dean M, Plasterk RH: Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J. 1996 Nov 15;15(22):6132-43. Nematodes were found to be hypersensitive to heavy metals when both the MRP homologue, mrp-1, and a member of the P-glycoprotein (Pgp) gene family, pgp-1, were deleted. |
1(0,0,0,1) | Details |
| 14971641 | Xie Y, Liu J, Liu Y, Klaassen CD, Waalkes MP: Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b (-/-) double knockout mice. Mol Cell Biochem. 2004 Jan;255(1-2):11-8. Multidrug-resistance gene knockout mdr1a/1b (-/-) mice, which are deficient in P-glycoproteins, are more sensitive than wild-type (WT) mice to acute arsenic toxicity. Thus, mdr1a/1b (-/-) and WT mice were exposed to sodium arsenite (0-80 ppm as arsenic) in the drinking water for 10 weeks at which time hepatic arsenic accumulation, lipid peroxidation (LPO), redox status and change in gene expression level were assessed. |
1(0,0,0,1) | Details |
| 12387749 | Brambila EM, Achanzar WE, Qu W, Webber MM, Waalkes MP: Chronic arsenic-exposed human prostate epithelial cells exhibit stable arsenic tolerance: mechanistic implications of altered cellular and glutathione S-transferase. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):99-107. Our results indicate that this tolerance in human cells involves increases in GSH levels and GST activity that allow for more efficient arsenic efflux by MRP1 and MDR1. RWPE-1 cells continuously exposed to 5 microM sodium arsenite for > or =18 weeks exhibited dramatic resistance to acute arsenite toxicity. |
1(0,0,0,1) | Details |
| 8968083 | Lorico A, Rappa G, Flavell RA, Sartorelli AC: Double knockout of the MRP gene leads to increased drug sensitivity in vitro. Cancer Res. 1996 Dec 1;56(23):5351-5. The cytotoxic activities of etoposide, teniposide, vincristine, doxorubicin, daunorubicin, and sodium arsenite were significantly greater in double knockout cells than in parental wild-type ES cells; single knockout ES cells displayed an intermediate level of sensitivity. |
0(0,0,0,0) | Details |
| 1913647 | Huot J, Roy G, Lambert H, Chretien P, Landry J: Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein. Cancer Res. 1991 Oct 1;51(19):5245-52. A statistically significant increased survival relative to the parental cells was observed following treatment with daunorubicin (three clones studied), colchicine, vincristine, actinomycin D, peroxide, and sodium arsenite (one clone studied). |
0(0,0,0,0) | Details |
| 17671726 | Tachiwada T, Chen ZS, Che XF, Matsumoto M, Haraguchi M, Gotanda T, Sumizawa T, Furukawa T, Nishiyama K, Seki N, Yamamoto M, Nakagawa M, Akiyama S: Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells. Oncol Rep. 2007 Sep;18(3):721-7. KAS cells were resistant to sodium arsenite (22-fold) and showed a reduced accumulation of arsenite as a result of an active efflux mechanism. |
0(0,0,0,0) | Details |