| Name | interferon gamma |
|---|---|
| Synonyms | IFG; IFI; IFN gamma; IFNG; IFNgamma; Immune interferon; Interferon gamma; Interferon gamma precursor… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17003472 | Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, Kondo T: Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. Am J Pathol. 2006 Oct;169(4):1118-28. |
7(0,0,1,2) | Details |
| 17608860 | Yamaguchi E, Yamanoi A, Ono T, Nagasue N: Experimental investigation of the role of endothelin-1 in idiopathic portal hypertension. J Gastroenterol Hepatol. 2007 Jul;22(7):1134-40. In a second experiment, B and T lymphocytes and monocyte-derived macrophages cultured from healthy human peripheral blood were stimulated with sodium arsenite, arsenate, lipopolysaccharide and interferon-gamma. |
6(0,0,1,1) | Details |
| 8903404 | de Vera ME, Kim YM, Wong HR, Wang Q, Billiar TR, Geller DA: Heat shock response inhibits cytokine-inducible synthase expression in rat hepatocytes. Hepatology. 1996 Nov;24(5):1238-45. Sodium arsenite (Ars) or hyperthermia (43 degrees C) induced the synthesis of hsp72 messenger RNA (mRNA) and protein in hepatocytes, indicating activation of the HSR. In the absence of the HSR, combinations of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) stimulated high levels of NOS2 mRNA and (NO) synthesis. |
1(0,0,0,1) | Details |
| 15116095 | Cheng HY, Li P, David M, Smithgall TE, Feng L, Lieberman MW: Arsenic inhibition of the JAK-STAT pathway. Oncogene. 2004 Apr 29;23(20):3603-12. Pretreatment with sodium arsenite strongly inhibited IL-6-inducible STAT3 phosphorylation in HepG2 cells and did not affect its serine phosphorylation. Both cellular and subcelluar experiments showed that the inhibition of JAK-STAT signaling resulted from JAK kinase's direct interaction with arsenite, and that arsenic's suppression of JAK kinase activity also occurred in the interferon gamma (IFNgamma) pathway. |
1(0,0,0,1) | Details |
| 18407307 | Soto-Pena GA, Vega L: Arsenic interferes with the signaling transduction pathway of T cell receptor activation by increasing basal and induced phosphorylation of Lck and Fyn in spleen cells. Toxicol Appl Pharmacol. 2008 Jul 15;230(2):216-26. Epub 2008 Mar 10. Intra-gastric exposure to arsenic (as sodium arsenite) for 30 days (1, 0.1, or 0.01 mg/kg/day), reduced the proportion of CD4+ cells and the CD4+/CD8+ ratio in the spleen, increasing the proportion of CD11b+ cells. Arsenic exposure reduced the proliferative response of SMC to Con-A, and also reduced secretion of IL-2, IL-6, IL-12 and IFNgamma. |
1(0,0,0,1) | Details |
| 7743356 | Abello PA, Buchman TG: Heat shock-induced cell death in murine microvascular endothelial cells depends on priming with tumor necrosis factor-alpha or interferon-gamma. Shock. 1994 Nov;2(5):320-3. When these endothelial cells were treated first with tumor necrosis factor-alpha followed by induction of the heat shock response with either heat or sodium arsenite (As), a standard chemical inducer of the heat shock response in vitro, a tumor necrosis factor dose-dependent cytotoxicity was observed, similar to that which we had seen previously in porcine endothelial cells primed with LPS. |
2(0,0,0,2) | Details |
| 20339924 | Das S, Pan D, Bera AK, Rana T, Bhattacharya D, Bandyapadyay S, De S, Sreevatsava V, Bhattacharya S, Das SK, Bandyopadhayay S: Sodium arsenite mediated immuno-disruption through alteration of transcription profile of cytokines in chicken splenocytes under in vitro system. Mol Biol Rep. 2010 Mar 26. Relative quantification of expression of IFNgamma and IL2 revealed that both genes were significantly down regulated (P < 0.001) at both concentrations at each time point. iNOS gene was rapidly down regulated in splenocytes at 24 h at the high doses of As treated splenocyte, a gradual decreasing trend at low doses. |
1(0,0,0,1) | Details |
| 8206135 | Soete M, Camus D, Dubremetz JF: Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro. Exp Parasitol. 1994 Jun;78(4):361-70. The expression of bradyzoite-specific proteins has been induced by modifying the culture conditions in any of the following three ways: increasing the pH of the culture medium (pH 8), shifting temperature from 37 to 43 degrees C, or performing a sodium arsenite treatment. Interferon-gamma, described as involved in the control of toxoplasmosis in vivo, was inefficient to trigger bradyzoite proteins expression in HFF host cells in vitro. |
1(0,0,0,1) | Details |
| 19083458 | Pai MH, Chien YW, Tsai YH, Hu YM, Yeh SL: reduces the expression of leukocyte integrins leukocyte function-associated antigen-1 and macrophage antigen-1 in mice exposed to arsenic. Nutr Res. 2008 Aug;28(8):544-9. The control group drank deionized water, whereas the experimental group drank deionized water containing 50 ppm of sodium arsenite. |
0(0,0,0,0) | Details |
| 7955528 | Misaki T, Takeuchi R, Miyamoto S, Hirano A, Kasagi K, Konishi J: Induction in vitro of 72-kD heat shock protein in a continuous culture of rat thyroid cells, FRTL5. Clin Exp Immunol. 1994 Nov;98(2):234-9. In the FRTL5 rat cell line, which had been heated at 42.5 degrees C or treated with sodium arsenite, expression of hsp-72 was examined with immunoperoxidase staining and immunoprecipitation of the metabolically labelled protein using a specific MoAb. |
0(0,0,0,0) | Details |