| Name | multidrug resistance associated protein 1 |
|---|---|
| Synonyms | ABC29; MRP; MRP1; ABCC; ABCC 1; ABCC1; ATP binding cassette subfamily C member1; ATP binding cassette sub family C member 1… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11855834 | Lorico A, Bertola A, Baum C, Fodstad O, Rappa G: Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice. Biochem Biophys Res Commun. 2002 Mar 1;291(3):617-22. We now report that the retroviral vector-mediated overexpression of MRP1 and of the two subunits of gamma-GCS (heavy and light) resulted in higher intracellular levels and in a greater level of resistance to sodium arsenite and antimony compared to the overexpression of MRP1 and gamma-GCS heavy alone. |
35(0,1,1,5) | Details |
| 11278867 | Ito K, Olsen SL, Qiu W, Deeley RG, Cole SP: Mutation of a single conserved in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. J Biol Chem. 2001 May 11;276(19):15616-24. Epub 2001 Feb 21. In contrast, resistance to sodium arsenite was only partially diminished, and resistance to antimony remained comparable to that of cells expressing wild-type MRP1. |
10(0,0,1,5) | Details |
| 17003472 | Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, Kondo T: Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. Am J Pathol. 2006 Oct;169(4):1118-28. |
10(0,0,1,5) | Details |
| 16672223 | Lee TC, Ho IC, Lu WJ, Huang JD: Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line. J Biol Chem. 2006 Jul 7;281(27):18401-7. Epub 2006 May 3. We therefore compared expression of the multidrug resistance-associated proteins MRP1, MRP2, and MRP3 in these two cell lines. |
2(0,0,0,2) | Details |
| 14522917 | Liang XJ, Shen DW, Garfield S, Gottesman MM: Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines. Cancer Res. 2003 Sep 15;63(18):5909-16. The accumulation of [(14) C] carboplatin and [(3) H] methotrexate is reduced in single-step KB epidermoid adenocarcinoma (KB-CP) cells, which are cross-resistant to carboplatin, methotrexate, and sodium arsenite. In these KB-CP cells, multidrug resistance is accompanied by mislocalization of multidrug resistance associated protein (MRP) 1 and other membrane proteins such as -binding protein. |
2(0,0,0,2) | Details |
| 14967012 | Kala SV, Kala G, Prater CI, Sartorelli AC, Lieberman MW: Formation and urinary excretion of arsenic triglutathione and methylarsenic diglutathione. Chem Res Toxicol. 2004 Feb;17(2):243-9. Following administration of sodium arsenite to these mice, approximately 60-70% of urinary arsenic is present as one of these GSH conjugates. Rodents deficient in three known ABC family transporters (MRP1, MRP2, and MDR1a/1b) exhibited urinary arsenic levels similar or greater than those in wild-type rodents; however, administration of MK571, an MRP inhibitor, reduced urinary arsenic excretion by almost 50%. |
2(0,0,0,2) | Details |
| 12387749 | Brambila EM, Achanzar WE, Qu W, Webber MM, Waalkes MP: Chronic arsenic-exposed human prostate epithelial cells exhibit stable arsenic tolerance: mechanistic implications of altered cellular and glutathione S-transferase. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):99-107. Our results indicate that this tolerance in human cells involves increases in GSH levels and GST activity that allow for more efficient arsenic efflux by MRP1 and MDR1. RWPE-1 cells continuously exposed to 5 microM sodium arsenite for > or =18 weeks exhibited dramatic resistance to acute arsenite toxicity. |
1(0,0,0,1) | Details |
| 15694464 | Kimura A, Ishida Y, Wada T, Yokoyama H, Mukaida N, Kondo T: MRP-1 expression levels determine strain-specific susceptibility to arsenic-induced renal injury between C57BL/6 and BALB/c mice. Toxicol Appl Pharmacol. 2005 Feb 15;203(1):53-61. To clarify the pathophysiological mechanism underlying acute renal injury caused by acute exposure to arsenic, we subcutaneously injected both BALB/c and C57BL/6 mice with sodium arsenite (NaAs; 13.5 mg/kg). |
0(0,0,0,0) | Details |
| 17671726 | Tachiwada T, Chen ZS, Che XF, Matsumoto M, Haraguchi M, Gotanda T, Sumizawa T, Furukawa T, Nishiyama K, Seki N, Yamamoto M, Nakagawa M, Akiyama S: Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells. Oncol Rep. 2007 Sep;18(3):721-7. KAS cells were resistant to sodium arsenite (22-fold) and showed a reduced accumulation of arsenite as a result of an active efflux mechanism. |
0(0,0,0,0) | Details |