Protein Information

Name GATA 4
Synonyms GATA binding factor 4; GATA binding protein 4; GATA 4; GATA4; Transcription factor GATA 4; GATA binding protein 4s; Transcription factor GATA 4s

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18154518 Kim J, Kang HM, Kim H, Kim MR, Kwon HC, Gye MC, Kang SG, Yang HS, You J: Ex vivo characteristics of human amniotic membrane-derived stem cells. . Cloning Stem Cells. 2007 Winter;9(4):581-94.


RT-PCR analysis showed that all four HAM cell lines consistently expressed genes of Oct-4, Rex-1, SCF, NCAM, nestin, BMP-4, GATA-4, HNF-4alpha, vimentin, and CK18, regardless of the passage number.
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18617272 Gofflot S, Kischel P, Thielen C, Radermacher V, Boniver J, de Leval L: Characterization of an antibody panel for immunohistochemical analysis of canine muscle cells. Vet Immunol Immunopathol. 2008 Oct 15;125(3-4):225-33. Epub 2008 Jun 8.


Specific staining was achieved with eight antibodies, of which six were cytoplasmic markers (desmin, HDAC8, MHC, SMA, Troponin I and Troponin T) and two were cardiac nuclear markers (GATA-4 and Nkx-2.5).
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20041970 Khan M, Mohsin S, Khan SN, Riazuddin S: Repair of senescent myocardium by mesenchymal stem cells is dependent on the age of donor mice. J Cell Mol Med. 2009 Dec 11.


Real time RT-PCR analysis for VEGF, SDF-1a and GATA-4 genes further confirmed the effect of age on MSC differentiation towards cardiac lineages and enhanced angiogenesis.
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18224284 Lopez V, Keen CL, Lanoue L: Prenatal zinc deficiency: influence on heart morphology and distribution of key heart proteins in a rat model. Biol Trace Elem Res. 2008 Jun;122(3):238-55. Epub 2008 Jan 26.


Fetuses were collected on GD 13.5, 15.5, and 18.5 and processed for GATA-4, FOG-2, connexin-43 (Cx43), HNK-1, smooth muscle alpha-actin (SMA) and cleaved caspase-3 protein expression.
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19544463 Andersen DC, Andersen P, Schneider M, Jensen HB, Sheikh SP: Murine "cardiospheres" are not a source of stem cells with cardiomyogenic potential. Stem Cells. 2009 Jul;27(7):1571-81.


Additionally, using in vitro culture, fluorescence-activated cell sorting, and immunofluorescence, we demonstrate that these CSs are generated by cellular aggregation of GATA-4 (+)/collagen I (+)/alpha-smooth muscle actin (SMA)(+)/CD45 (-) cells rather than by clonal cell growth.
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19246878 Zhang X, Zhang CS, Liu YC, Yang XQ, Xiong SH, Wen Y, Jiang EP, Li R, Zhang ZY, Liu F, Ye Y: Isolation, culture and characterization of cardiac progenitor cells derived from human embryonic heart tubes. Cells Tissues Organs. 2009;190(4):194-208. Epub 2009 Feb 23.


GATA-4 expression of Nkx2.5+ hCPCs was higher than that of embryonic limb bud mesenchymal cells of the control group (p < 0.05).
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