Protein Information

Name VEGF receptor 1
Synonyms FLT; Tyrosine protein kinase receptor; FLT1; FMS related tyrosine kinase 1; FRT; Flt 1; Fms like tyrosine kinase 1; Fms related tyrosine kinase 1 (Vascular endothelial growth factor/vascular permeability factor receptor) variant…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18550647 Ardura JA, Berruguete R, Ramila D, Alvarez-Arroyo MV, Esbrit P: Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney. Am J Physiol Renal Physiol. 2008 Aug;295(2):F415-25. Epub 2008 Jun 11.


VEGF receptor (VEGFR)-1 was upregulated, while VEGFR-2 was downregulated (at both mRNA and protein levels) in the mouse kidney within 2-6 days after ureteral obstruction.
3(0,0,0,3) Details
19336420 Ibba-Manneschi L, Manetti M, Milia AF, Miniati I, Benelli G, Guiducci S, Mecacci F, Mello G, Di Lollo S, Matucci-Cerinic M: Severe fibrotic changes and altered expression of angiogenic factors in maternal scleroderma: placental findings. Ann Rheum Dis. 2010 Feb;69(2):458-61. Epub 2009 Mar 30.


The sections were stained with Masson's trichrome and phosphotungstic-acid-haematoxylin and immunostained for connective tissue growth factor (CTGF), alpha-smooth muscle actin (alpha-SMA), vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and receptors VEGFR-1 and VEGFR-2.
2(0,0,0,2) Details
19180920 He CM, Zheng FL, Lian YG, Liu YP: [Relationship between the effect of vascular endothelial growth factor on epithelial-mesenchymal transition of HK-2 cells and the expressions of bone morphogenetic protein-7 and inhibitor of DNA binding/differentiation]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Dec;30(6):703-10.


METHODS: The cultured HK-2 cells were co-treated with transforming growth factor-beta1 (TGF-beta1) (5 ng/ml) and VEGF165 (0.1, 1, 10, 100 ng/ml), or with TGF-beta1 (5 ng/ml) and VEGF receptor-1 neutralized antibody (10 microg/ ml), and were also co-treated with TGF-beta1 (5 ng/ml) and VEGF165 (100 ng/ml) with or without activin receptor-like kinase 6 (Alk6)/Fc Chimera (2 microg/ml, to neutralize endogenous BMP-7) for 48 hours. mRNA and protein expressions of alpha-smooth muscle actin (alpha-SMA), E-cadherin, BMP-7, Id2 and Id3 of HK-2 cells were assessed with double-stain immunocytochemistry, real-time PCR and Western blot respectively.
2(0,0,0,2) Details