Protein Information

Name desmin
Synonyms CMD1I; CSM 1; CSM 2; CSM1; CSM2; DES; DES Skeletin; Desmin…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19285070 Chaurasia SS, Kaur H, de Medeiros FW, Smith SD, Wilson SE: Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury. Exp Eye Res. 2009 Aug;89(2):133-9. Epub 2009 Mar 11.

4(0,0,0,4) Details
18925331 Gibelli NE, Tannuri U, Mello ES: Immunohistochemical studies of stellate cells in experimental cholestasis in newborn and adult rats. Clinics (Sao Paulo). 2008 Oct;63(5):689-94.


Hepatic biopsies were obtained and immunohistochemical semi-quantification of desmin and alpha-SMA expression was performed in hepatic stellate cells and in myofibroblasts in the portal space, and between the portal space and the liver lobule.
3(0,0,0,3) Details
19377054 Roy-Chaudhury P, Wang Y, Krishnamoorthy M, Zhang J, Banerjee R, Munda R, Heffelfinger S, Arend L: Cellular phenotypes in human stenotic lesions from haemodialysis vascular access. Nephrol Dial Transplant. 2009 Sep;24(9):2786-91. Epub 2009 Apr 17.


METHODS: Discarded tissue segments were collected from the stenotic portions (usually near the graft-vein anastomosis or the AV anastomosis) of 23 dialysis grafts and 20 AV fistulae, and examined for expression of smooth muscle alpha actin, desmin, vimentin and a macrophage marker.
3(0,0,0,3) Details
18617272 Gofflot S, Kischel P, Thielen C, Radermacher V, Boniver J, de Leval L: Characterization of an antibody panel for immunohistochemical analysis of canine muscle cells. Vet Immunol Immunopathol. 2008 Oct 15;125(3-4):225-33. Epub 2008 Jun 8.


Specific staining was achieved with eight antibodies, of which six were cytoplasmic markers (desmin, HDAC8, MHC, SMA, Troponin I and Troponin T) and two were cardiac nuclear markers (GATA-4 and Nkx-2.5).
1(0,0,0,1) Details
20051653 Iwanaga K, Murata T, Hori M, Ozaki H: Isolation and characterization of bovine intestinal subepithelial myofibroblasts. J Pharmacol Sci. 2010 Jan;112(1):98-104. Epub 2010 Jan 6.


After 2-week incubation, alpha-SMA+ / vimentin+ / desmin (-) ISMFs were harvested and applied for experiments.
1(0,0,0,1) Details
19914391 Perez-Carreon JI, Martinez-Perez L, Loredo ML, Yanez-Maldonado L, Velasco-Loyden G, Vidrio-Gomez S, Ramirez-Salcedo J, Hernandez-Luis F, Velazquez-Martinez I, Suarez-Cuenca JA, Hernandez-Munoz R, de Sanchez VC: An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl (4)-induced rat cirrhosis. Int J Biochem Cell Biol. 2010 Feb;42(2):287-96. Epub 2009 Nov 13.


Treatment of cirrhotic rats with IFC305 for 5 or 10 weeks compared to saline control, induced: (1) reduction of fibrosis (50-70%) and of collagen, of alpha-SMA and desmin proteins, as well as of activated HSCs in liver, (2) increased collagenase activity and cell number of lipid-storing HSC, (3) improved serum parameters of liver function, such as reduced activity of aminotransferases and bilirubin.
1(0,0,0,1) Details
20030533 Vieira Neto OM, Russo EM, Costa RS, Coimbra TM, Dantas M: Effect of the absence of interleukin-12 on mesangial proliferative glomerulonephritis induced by habu snake venom. Ren Fail. 2009;31(10):964-70.


Compared to IL12+/+ mice, IL12-/- mice showed lower scores of glomerular desmin expression on D7 [1.55 (1.32; 1.65) vs. 1.12 (1.07; 1.22); p < 0.01] and D14 [1.60 (1.55; 1.75) vs. 1.20 (1.15; 1.20); p < 0.001], respectively, and lower scores of glomerular alpha-SMA expression on D14 [0.30 (0.21; 0.38) vs. 0.16 (0.26; 0.36); p < 0.001], respectively.
1(0,0,0,1) Details
19688349 Karaoz E, Aksoy A, Ayhan S, Sariboyaci AE, Kaymaz F, Kasap M: Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers. Histochem Cell Biol. 2009 Nov;132(5):533-46. Epub 2009 Aug 14.


Immunohistochemistry and RT-PCR results indicated that BM-MSCs expressed myogenic (desmin, myogenin, myosin IIa, and alpha-SMA), neurogenic (gamma-enolase, MAP2a,b, c-fos, nestin, GFAP and beta III tubulin), and osteogenic (osteonectin, osteocalcin, osteopontin, Runx-2, BMP-2, BMP-4 and type I collagen) markers without stimulation towards differentiation.
1(0,0,0,1) Details
18413367 Wu MP, Young MJ, Tzeng CC, Tzeng CR, Huang KF, Wu LW, Chou CY: A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer. Carcinogenesis. 2008 Jun;29(6):1115-23. Epub 2008 Apr 15.


Immunohistochemistry examinations in the human surgical specimens have shown that a downregulation of TSP-1 during the progression of cervical carcinogenesis was accompanied by an emergence in the upregulation of stroma markers, alpha-smooth muscle actin (alpha-SMA) and desmin.
3(0,0,0,3) Details
18608982 Shi X, Han W, Yamamoto H, Tang W, Lin X, Xiu R, Trune DR, Nuttall AL: The Cochlear Pericytes. Microcirculation. 2008 Jul 1:1.


Materials and Methods: Cochlear pericytes were identified by the immunofluorescence labeling of pericyte marker proteins, including alpha-smooth muscle actin (alpha-SMA), desmin, Thy-1, tropomyosin, and NG2, and by morphological identification, using fluorescence, electron, and differential interference contrast microscopy.
2(0,0,0,2) Details
18251780 Adachi Y, Horie Y, Kitamura Y, Nakamura H, Taniguchi Y, Miwa K, Fujioka S, Nishimura M, Hayashi K: CD1a expression in PEComas. Pathol Int. 2008 Mar;58(3):169-73.


Generally, nearly all PEComas have immunoreactivity for both melanocytic (HMB-45 and/or melan A) and smooth muscle (actin (SMA) and/or desmin) markers.
1(0,0,0,1) Details
17943409 Yorulmaz G, Erdogan G, Pestereli HE, Savas B, Karaveli FS: Epithelioid leiomyosarcoma with rhabdoid features. Wien Klin Wochenschr. 2007;119(17-18):557-60.


Immunopositive cytoplasmic staining for myoglobulin and desmin was seen in rhabdoid cells, and cytokeratin immunopositivity was observed in epithelioid and some rhabdoid cells.
1(0,0,0,1) Details
19035117 Li X, Liu HG, Xie XJ, Han YD, Li M: [Clinicopathologic study of sinonasal teratocarcinosarcoma and its contrast with olfactory neuroblastoma]. Zhonghua Bing Li Xue Za Zhi. 2008 Jul;37(7):458-64.


The spindle cells expressed vimentin, SMA, desmin, myosin and myoglobin.
1(0,0,0,1) Details
18947621 Rolle U, Puri P: Structural basis of voiding dysfunction in megacystis microcolon intestinal hypoperistalsis syndrome. J Pediatr Urol. 2006 Aug;2(4):277-84. Epub 2006 Apr 4.


Single fluorescence immunohistochemistry for alpha-smooth muscle actin (SMA), desmin, dystrophin, vinculin and collagen types I and III was carried out.
2(0,0,0,2) Details
19175711 Ramirez-Amador V, Martinez-Mata G, Gonzalez-Ramirez I, Anaya-Saavedra G, de Almeida OP: Clinical, histological and immunohistochemical findings in oral Kaposi's sarcoma in a series of Mexican AIDS patients. J Oral Pathol Med. 2009 Apr;38(4):328-33. Epub 2009 Jan 23.


Immunohistochemical studies were performed for vimentin, alpha SMA, desmin, C-kit, CD34, D2-40 and LANA-1 [human herpesvirus-8 (HHV-8)].
2(0,0,0,2) Details
18439235 Sachdeva MU, Vankalakunti M, Rangan A, Radotra BD, Chhabra R, Vasishta RK: The role of immunohistochemistry in medullomyoblastoma - a case series highlighting divergent differentiation. Diagn Pathol. 2008 Apr 25;3:18.


All these cases were subjected to a panel of immunohistochemical stains, including Desmin, GFAP, NFP, HMB45, SMA, S100, CK and EMA.
1(0,0,0,1) Details
17628937 Hirai T, Ikeda D, Sakai A: [A case report: retroperitoneal inflammatory fibrosarcoma that revealed progressive enlargement]. Hinyokika Kiyo. 2007 Jun;53(6):393-6.


Immunostaining examination showed positive staining for alpha-smooth muscle actin (SMA), vimentin, cytokeatins, and CD 68, whereas desmin, CD 34, and p53 were negative.
1(0,0,0,1) Details
20070153 Eyden B: Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report. Ultrastruct Pathol. 2010 Feb;34(1):42-7.


The tumor was positive for vimentin, desmin, alpha-smooth-muscle actin, alpha-sarcomeric actin, myogenin, MyoD1, and CD68.
1(0,0,0,1) Details
19937078 Mouravas VK, Koletsa T, Sfougaris DK, Philippopoulos A, Petropoulos AS, Zavitsanakis A, Kostopoulos I: Smooth muscle cell differentiation in the processus vaginalis of children with hernia or hydrocele. Hernia. 2009 Nov 24.


The aim of this study was to evaluate the diversity and differentiation of smooth muscle phenotypes in sacs associated with inguinal hernia and hydrocele through the expression of alpha-smooth muscle actin (SMA), h-caldesmon, desmin, and vimentin.
2(0,0,0,2) Details
17761239 Stathas D, Kalfakis N, Kararizou E, Manta P: Spinal muscular atrophy: DNA fragmentation and immaturity of muscle fibers. Acta Histochem. 2008;110(1):53-8. Epub 2007 Aug 29.


The presence of apoptotic fibers and the embryonic proteins desmin and vimentin were investigated in muscle biopsy specimens from patients with spinal muscular atrophy (SMA).
2(0,0,0,2) Details
19451194 Mehasseb MK, Bell SC, Habiba MA: The effects of tamoxifen and estradiol on myometrial differentiation and organization during early uterine development in the CD1 mouse. Reproduction. 2009 Aug;138(2):341-50. Epub 2009 May 18.


We examined the sections histologically, using image analysis and immunohistochemistry for alpha-smooth muscle actin (alpha-SMA), desmin, vimentin, laminin, fibronectin, and estrogen receptor-alpha.
2(0,0,0,2) Details
19342509 Gieling RG, Wallace K, Han YP: Interleukin-1 participates in the progression from liver injury to fibrosis. Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1324-31. Epub 2009 Apr 2.


In injured livers, MMP-9 was predominantly colocalized to desmin-positive cells, suggesting that HSCs are MMP-producing cells in vivo.
1(0,0,0,1) Details
18558191 Nakano R, Paran TS, Rolle U, Puri P: Age-related changes in the neuromuscular development of the internal anal sphincter. J Pediatr Surg. 2008 Jun;43(6):1106-10.


METHODS: Paraffin sections of IAS from 5 different age groups, E60, E90, 1 day, 4, and 12 weeks old, were stained with protein gene product 9.5 (PGP9.5), *-smooth muscle actin (*-SMA), caldesmon (CALD), calponin (CALP), and desmin (DES) antibodies.
1(0,0,0,1) Details
18790992 Ichikawa T, Sugiura H, Koarai A, Yanagisawa S, Kanda M, Hayata A, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M: Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L800-8. Epub 2008 Sep 12.


Human fetal lung fibroblasts were treated with various concentrations of authentic peroxynitrite or a peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1), and the expressions of alpha-smooth muscle actin (alpha-SMA) and desmin, markers of myofibroblast differentiation, were evaluated.
2(0,0,0,2) Details
19615014 Kluger N, Dumas-Tesici A, Hamel D, Brousse N, Fraitag S: Fibroblastic rheumatism: fibromatosis rather than non-Langerhans cell histiocytosis. J Cutan Pathol. 2009 Jul 13.


Histopathology and immunochemistry studies were performed on skin biospies using CD68, CD163, desmin, factor XIIIa, CD34, smooth muscle actin, PS100, epithelial membrane antigen, and calponin.
2(0,0,0,2) Details
18503097 Van Beneden K, van Grunsven LA, Geers C, Pauwels M, Desmouliere A, Verbeelen D, Geerts A, Van den Branden C: CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis. Nephrol Dial Transplant. 2008 Nov;23(11):3464-71. Epub 2008 May 25.


Western blotting was performed to semi-quantify the expression levels of vimentin, desmin, alpha-SMA and CRBP-I.
1(0,0,0,1) Details
20103680 Schadler KL, Zweidler-McKay PA, Guan H, Kleinerman ES: Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma. Clin Cancer Res. 2010 Feb 1;16(3):848-56. Epub 2010 Jan 26.


Inhibition of DLL4 expression by short hairpin RNA correlated with the decreased numbers of BM-derived cells in tumor vessels and the decreased numbers of alpha-SMA (+), desmin (+), and NG2 (+) pericytes/vSMCs, as well as increased tumor hypoxia.
1(0,0,0,1) Details
19527786 Chang KT, Tsai MJ, Cheng YT, Chen JJ, Hsia RH, Lo YS, Ma YR, Weng CF: Comparative atomic force and scanning electron microscopy: an investigation of structural differentiation of hepatic stellate cells. J Struct Biol. 2009 Sep;167(3):200-8. Epub 2009 Jun 13.


The state of cultured rat HSCs was determined using primarily fluorescence microscopy (UV), immunofluorescence (IF) (Glial fibrillary acidic protein (GFAP), Desmin, alpha-smooth muscle actin (alpha-SMA), F-actin) and immunocytochemistry (ICC) (GFAP, Desmin, alpha-SMA, Fibulin-2).
2(0,0,0,2) Details
18261305 Luo DL, Liu YH, Zhuang HG, Luo XL: [Tumors showing perivascular epithelioid cell differentiation: a clinicopathologic study of 39 cases]. Zhonghua Yi Xue Za Zhi. 2007 Nov 6;87(41):2909-13.


Immunohistochemistry (HIC) was used to detect the expression of pan-cytokeratin (CK), S-100 protein, smooth muscle actin (SMA), desmin, vimentin, HMB45, Melan-A, microphthalmia transcription factor (MiTF), CD117, and CD34 in the specimens of the tumors obtained during operation.
2(0,0,0,2) Details
19086261 Shi X, Han W, Yamamoto H, Tang W, Lin X, Xiu R, Trune DR, Nuttall AL: The cochlear pericytes. Microcirculation. 2008 Aug;15(6):515-29.


MATERIALS AND METHODS: Cochlear pericytes were identified by the immunofluorescence labeling of pericyte marker proteins, including alpha-smooth muscle actin (alpha-SMA), desmin, Thy-1, tropomyosin, and NG2, and by morphological identification, using fluorescence, electron, and differential interference contrast microscopy.
2(0,0,0,2) Details
20004561 Katori Y, Cho BH, Song CH, Fujimiya M, Murakami G, Kawase T: Smooth-to-striated muscle transition in human esophagus: an immunohistochemical study using fetal and adult materials. Ann Anat. 2010 Feb 20;192(1):33-41. Epub 2009 Nov 10.


METHODS: In horizontal sections of 10 human fetuses between 9 and 16 weeks of gestation, we identified immunoreactivity for smooth muscle actin (SMA), striated muscle myosin heavy chain (MyH), desmin, PGP9.5, S100 protein, c-kit, and CD68 in the thoracic esophagus.
2(0,0,0,2) Details
17845222 Madekurozwa MC: An immunohistochemical study of the distribution of intermediate filaments in the ovary of the emu (Dromaius novaehollandiae). Anat Histol Embryol. 2007 Oct;36(5):336-42.


The immunohistochemical localization of the intermediate filaments desmin, vimentin and smooth muscle actin (SMA) in the ovary of the emu was described in the present study.
1(0,0,0,1) Details
20052656 Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA: Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010 Mar;51(3):1027-36.


All beta-gal-positive cells exhibited abundant cytoplasm, a typical morphology of hepatocytes, and expressed none of the mesenchymal markers including alpha-SMA, FSP-1, desmin, and vimentin.
1(0,0,0,1) Details
19085956 Asahina K, Tsai SY, Li P, Ishii M, Maxson RE Jr, Sucov HM, Tsukamoto H: Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar;49(3):998-1011.


Based on the location and immunostaining with conventional and newly disclosed markers, we have identified three distinct populations of fetal liver mesenchymal cells expressing both desmin and p75 neurotrophin receptor (p75NTR): HSCs in the liver parenchyma; perivascular mesenchymal cells expressing alpha-smooth muscle actin (alpha-SMA); and submesothelial cells associated with the basal lamina beneath mesothelial cells and expressing activated leukocyte cell adhesion molecule (ALCAM) and platelet-derived growth factor receptor alpha.
1(0,0,0,1) Details
18400254 Qiu X, Montgomery E, Sun B: Inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma: a comparative study of clinicopathologic features and further observations on the immunohistochemical profile of myofibroblasts. Hum Pathol. 2008 Jun;39(6):846-56. Epub 2008 Apr 8.


The primary antibodies used in this study were specific for the ultrastructural subcellular components: (1) *-smooth muscle actin (*-SMA), muscle-specific actin (MSA), calponin, and h-caldesmon for myofilaments; (2) fibronectin for fibronexus; (3) laminin for basal lamina; (4) desmin and cytokeratin for intermediate filaments.
2(0,0,0,2) Details
19548033 Okabe H, Beppu T, Hayashi H, Horino K, Masuda T, Komori H, Ishikawa S, Watanabe M, Takamori H, Iyama K, Baba H: Hepatic stellate cells may relate to progression of intrahepatic cholangiocarcinoma. Ann Surg Oncol. 2009 Sep;16(9):2555-64. Epub 2009 Jun 23.


The HS cells in myofibroblasts of ICC were identified (double immunostaining) using antibodies for alpha-SMA, glial fibrillary acidic protein (GFAP), and desmin.
2(0,0,0,2) Details
19224450 Diaz-Gil JJ, Garcia-Monzon C, Rua C, Martin-Sanz P, Cereceda RM, Miquilena-Colina ME, Machin C, Fernandez-Martinez A, Garcia-Canero R: Liver growth factor antifibrotic activity in vivo is associated with a decrease in activation of hepatic stellate cells. Histol Histopathol. 2009 Apr;24(4):473-9.


Groups were compared in terms of liver alpha-smooth muscle actin (SMA) content (western blotting and immunohistochemistry), hepatic apoptosis, liver desmin content (western blotting), and serum endothelin-1 (ELISA).
1(0,0,0,1) Details
18518656 Han RI, Black A, Culshaw GJ, French AT, Else RW, Corcoran BM: Distribution of myofibroblasts, smooth muscle-like cells, macrophages, and mast cells in mitral valve leaflets of dogs with myxomatous mitral valve disease. Am J Vet Res. 2008 Jun;69(6):763-9.


PROCEDURES: A combination of standard histologic and immunohistochemical techniques was used to identify pathologic changes, the presence of mast cells, and the density and distribution of cells expressing vimentin, desmin, alpha-smooth muscle actin (alpha-SMA), smooth muscle myosin, and the macrophage marker MAC387.
1(0,0,0,1) Details
18815536 Zhang X, Cui Y, Fang L, Li F: Chronic high-fat diets induce oxide injuries and fibrogenesis of pancreatic cells in rats. Pancreas. 2008 Oct;37(3):e31-8.


Histopathologic changes were observed by Sirius red staining for fibrosis and immunostaining of the pancreatic stellate cells for desmin, alpha-smooth muscle actin, platelet-derived growth factor receptor type beta, and transforming growth factor beta1.
2(0,0,0,2) Details
18949416 Tai WC, Chuah SK, Lin JW, Chen HH, Huang HY, Kuo CM, Yi LN, Lee CM, Changchien CS, Hu TH: Colorectal mesenchymal tumors - from smooth muscle tumors to stromal tumors. Oncol Rep. 2008 Nov;20(5):1157-64.


Immunohistochemical studies were performed with antibodies of CD117, CD34, smooth muscle actin (SMA), desmin, S-100, Ki-67 and PCNA for clinicopathologic and prognostic correlation.
2(0,0,0,2) Details
18021353 Lavranos G, Paschalis G, Angelopoulou R, Karandrea D, Goutas N: Casual discovery of a thoracic tumour showing histological features of undifferentiated pleomorphic sarcoma in a male Wistar laboratory rat. Anat Histol Embryol. 2007 Dec;36(6):433-6.


Immunohistochemistry was performed on the tissue using specific antibodies for several proliferation (Ki-67) and differentiation (S-100, CD-34, CD-68, pan-keratin, desmin and smooth muscle actin-SMA) markers.
1(0,0,0,1) Details
19780873 Fons ME, Bachhuber T, Plaza JA: Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. J Cutan Pathol. 2009 Sep 22.


Immunohistochemical studies were performed and the tumor cells were strongly positive for smooth muscle actin (SMA) and desmin.
1(0,0,0,1) Details
19323797 van Engelen E, Breeveld-Dwarkasing VN, Everts ME, van der Weyden GC, Taverne MA, Rutten VP: Smooth muscle cells of the bovine cervical stroma may have a secretory, rather than a contractile function during parturition. Reprod Domest Anim. 2009 Apr;44(2):303-11.


The smooth muscle bundles of the stroma were immunohistochemically analysed (n = 5) with regard to their integrity and cellular density, and the degree of staining for connexin-43, smooth muscle actin alpha (SMA), desmin and vimentin.
2(0,0,0,2) Details
19577381 Fraternali Orcioni G, Louis Ravetti J, Gaggero G, Bocca B, Bisceglia M: Primary embryonal spindle cell cardiac rhabdomyosarcoma: Case report. Pathol Res Pract. 2009 Jul 2.


At immunohistochemistry, the tumor cells stained strongly and diffusely with vimentin, muscle-specific actin, desmin and myogenin, and focally with fast-myosin and sarcomeric actin.
1(0,0,0,1) Details
20185896 Griesche N, Luttmann W, Luttmann A, Stammermann T, Geiger H, Baer PC: A Simple Modification of the Separation Method Reduces Heterogeneity of Adipose-Derived Stem Cells. Cells Tissues Organs. 2010 Feb 24.


Washing led to a significantly lower expression of desmin, smA and six2, and a higher expression of the stem cell markers nestin, oct-4 and sall-1, compared to standard isolated cells, while the immunomagnetically isolated cells showed no significant changes.
0(0,0,0,0) Details
19381675 Mansuroglu T, Dudas J, Elmaouhoub A, Joza TZ, Ramadori G: Hepatoblast and mesenchymal cell-specific gene-expression in fetal rat liver and in cultured fetal rat liver cells. Histochem Cell Biol. 2009 Jul;132(1):11-9. Epub 2009 Apr 19.


SMA-gene-expression increased during the passages, suggesting that myofibroblasts become the major cell population of fetal liver cell cultures over time.
0(0,0,0,0) Details
19706787 Shamhart PE, Luther DJ, Hodson BR, Koshy JC, Ohanyan V, Meszaros JG: Impact of type 1 diabetes on cardiac fibroblast activation: enhanced cell cycle progression and reduced myofibroblast content in the diabetic myocardium. Am J Physiol Endocrinol Metab. 2009 Aug 25.


Surprisingly, the hearts from the diabetic group contained lower levels of the myofibroblast marker alpha-smooth muscle actin (alpha-SMA) and higher levels of desmin and pecam.
1(0,0,0,1) Details
20123451 Fanburg-Smith JC, Auerbach A, Marwaha JS, Wang Z, Santi M, Judkins AR, Rushing EJ: Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases. Ann Diagn Pathol. 2010 Feb;14(1):8-14. Epub 2009 Dec 8.


Epithelial membrane antigen (EMA) and desmin were expressed focally in 35% and 50% of cases, respectively.
1(0,0,0,1) Details
18776162 Chang SC, Inui K, Lee WC, Hsuan SL, Chien MS, Chen CH, Chang SJ, Liao JW: Spontaneous rhabdomyosarcoma in a young Sprague-Dawley rat. Toxicol Pathol. 2008;36(6):866-70. Epub 2008 Sep 5.


Immunohistochemical staining also expressed intense granular cytoplasmic staining for desmin and myoglobin, with highly positive staining for PCNA, whereas alpha-smooth muscle actin (alpha-SMA) was negative.
1(0,0,0,1) Details
17991328 Huang KH, Liu JH, Wang LY, Wang LY, Li CQ, Zhu ZH, Li HG: [Endoscopic, clinicopathologic and immunohistochemical features of gastric stromal tumor]. Ai Zheng. 2007 Nov;26(11):1252-6.


The expression of CD117, CD34, smooth muscle actin (SMA), Desmin and S-100 were detected by immunohistochemistry.
1(0,0,0,1) Details
19952797 Liu ZJ, Zhang LJ, Zhao Q, Li QW, Wang EB, Ji SJ, Shu H: Pediatric synovial sarcoma of the sacrum: a case report. J Pediatr Orthop B. 2010 Mar;19(2):207-10.


Immunohistochemically, desmin and CD34 were negative.
1(0,0,0,1) Details
19145686 Zissis D, Zizi-Serbetzoglou A, Glava C, Grammatoglou X, Katsamagkou E, Nikolaidou ME, Vasilakaki T: Glomus tumor of the stomach: a case report. J BUON. 2008 Oct-Dec;13(4):581-4.


Biopsies taken from the lesion showed morphological and immunohistochemical [positivity for alphasmooth muscle actin (alpha-SMA) and vimentin, negativity for CD34, CD117, chromogranin, synaptophysin, desmin and S-100 protein] characteristics attributable to glomus tumor.
1(0,0,0,1) Details
19999136 Suzuki T, Harabayashi T, Abe T, Sazawa A, Shinohara N, Nonomura K: [Case of primary leiomyosarcoma of the seminal vesicle] . Nippon Hinyokika Gakkai Zasshi. 2009 Nov;100(7):703-6.


In our case, Immunohistological study by SMA and desmin was useful for histological diagnosis preoperatively.
1(0,0,0,1) Details
18446631 Pauli J, Gundelach R, Vanelli-Rees A, Rees G, Campbell C, Dubey S, Perry C: Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology. 2008 Jun;40(4):396-400.


Our objective is to evaluate the immunohistochemical phenotype of the stromal cell of JNA, particularly within the proliferative zone of the tumour, by application of antibodies against MNF116, CAM5.2, S-100, CD31, CD34, CD99, CD68, vimentin, EMA, SMA, desmin, calponin, Bcl-2 and (CD117) c-kit in a series of 54 cases.
1(0,0,0,1) Details
17674035 Budny T, Palmes D, Stratmann U, Minin E, Herbst H, Spiegel HU: Morphologic features in the regenerating liver--a comparative intravital, lightmicroscopical and ultrastructural analysis with focus on hepatic stellate cells. Virchows Arch. 2007 Oct;451(4):781-91. Epub 2007 Aug 3.


Morphological features were investigated by light microscopy, immunohistochemistry [alpha-smooth muscle actin (alpha-SMA), Desmin, vascular endothelial growth factor (VEGF)/VEGF receptor, Ki-67, ssDNA], intravital microscopy (sinusoid density, number of hepatocytes, and HSC), and electron microscopy focussed on cell-to-cell interactions.
1(0,0,0,1) Details
20169895 Sojka P, Pogrzebielski A, Orlowska-Heitzman J, Romanowska-Dixon B: [Mesectodermal leiomyoma of the ciliary body--case report] . Klin Oczna. 2009;111(10-12):350-3.


The co-expression of muscular (SMA, caldesmon, desmin), as well as neural markers (S-100 protein and synaptophysin), has been proved.
1(0,0,0,1) Details
20038894 Brasileiro BF, Martins-Filho PR, Piva MR, Silva LC, Nonaka CF, Miguel MC: Myofibroma of the oral cavity. Med Oral Patol Oral Cir Bucal. 2009 Dec 29.


An immunohistochemical panel consisting of antibodies to vimentin, SMA, HHF-35, S-100p and desmin must be achieved.
1(0,0,0,1) Details
18227731 Vasei M, Moch H, Mousavi A, Kajbafzadeh AM, Sauter G: Immunohistochemical profiling of Wilms tumor: a tissue microarray study. Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):128-34.


Stromal cells expressed SMA (21, 50%), actin (18, 48%), desmin (9, 20%), CD34 (7, 24%), CD57 (5, 18%), and CD56 (5, 15%).
1(0,0,0,1) Details
19052772 Van Rossen E, Vander Borght S, van Grunsven LA, Reynaert H, Bruggeman V, Blomhoff R, Roskams T, Geerts A: Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver. Histochem Cell Biol. 2009 Mar;131(3):313-25. Epub 2008 Dec 4.


With immunohistochemistry we examined the expression of synemin, desmin, vimentin, vinculin, neurotrophin-3 (NT-3), alpha-smooth muscle actin (alpha-SMA), cellular retinol-binding protein-1 (CRBP-1), glial fibrillary acidic protein (GFAP), cysteine- and glycine-rich protein 2 (CRP2), and cytoglobin/stellate cell activation-associated protein (cygb/STAP).
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19816704 Karaoz E, Dogan BN, Aksoy A, Gacar G, Akyuz S, Ayhan S, Genc ZS, Yuruker S, Duruksu G, Demircan PC, Sariboyaci AE: Isolation and in vitro characterisation of dental pulp stem cells from natal teeth. Histochem Cell Biol. 2010 Jan;133(1):95-112. Epub 2009 Oct 9.


Ultrastructural characteristics of hNDP-SCs showed more developed and metabolically active cells. hNDP-SCs and hBM-MSCs expressed some adipogenic (leptin, adipophilin and PPARgamma), myogenic (desmin, myogenin, myosinIIa, and alpha-SMA), neurogenic (gamma-enolase, MAP2a,b, c-fos, nestin, NF-H, NF-L, GFAP and betaIII tubulin), osteogenic (osteonectin, osteocalcin, osteopontin, Runx-2, and type I collagen) and chondrogenic (type II collagen, SOX9) markers without any stimulation towards differentiation under basal conditions.
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19059821 Chummun S, McLean NR, Abraham S, Youseff M: Desmoid tumour of the breast. . J Plast Reconstr Aesthet Surg. 2010 Feb;63(2):339-45. Epub 2008 Dec 6.


Immunochemistry showed strong positivity for vimentin and variable positivity for SMA and desmin, and patchy positivity for beta catenin.
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19827165 Roderfeld M, Rath T, Voswinckel R, Dierkes C, Dietrich H, Zahner D, Graf J, Roeb E: Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4-/- mice. Hepatology. 2010 Jan;51(1):267-76.


These CD34 (+) cells infiltrated hepatic lobules from portal fields and developed a desmin (+) phenotype expressing collagen type I in fibrotic parenchyma as well as in vitro after isolation by magnetic cell separation.
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18154518 Kim J, Kang HM, Kim H, Kim MR, Kwon HC, Gye MC, Kang SG, Yang HS, You J: Ex vivo characteristics of human amniotic membrane-derived stem cells. . Cloning Stem Cells. 2007 Winter;9(4):581-94.


Immunophenotype analysis of HAM cells revealed the presence of antigens for SSEA-3, SSEA-4, collagen type-I, -II, -III, -IV, -XII, fibronectin, alpha-SMA, vimentin, desmin, cytokeratin18 (CK18), HCAM-1, fibroblast surface protein, and human leukocyte antigen (HLA) ABC.
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17571460 Ke Q, Erbolat, Zhang HY, Bu H, Li S, Shi DN, Yang GH, Chen HJ, Wei B: Clinicopathologic features of pleomorphic hyalinizing angiectatic tumor of soft parts. Chin Med J. 2007 May 20;120(10):876-81.


Immunohistochemical stains for vimentin, S-100 protein, CD34, CD31, CD99, VEGF, desmin, CD117, alpha-SMA, and MIB-1 were performed with the Envision system.
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19461215 Do SH, Hong IH, Park JK, Ji AR, Kim TH, Kwak DM, Jeong KS: Two different types of malignant fibrous histiocytomas from pet dogs. J Vet Sci. 2009 Jun;10(2):169-71.


To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen.
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18359707 Liu J, Liu YH: [Expression of CD117, CD34, SMA, S-100 protein, Vim and desmin in patients with gastrointestinal stromal tumors]. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):438-40.

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19747592 Chaurasia SS, Kaur H, de Medeiros FW, Smith SD, Wilson SE: Reprint of "Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury". Exp Eye Res. 2009 Oct;89(4):590-6.

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19110482 Odaka C: Localization of mesenchymal cells in adult mouse thymus: their abnormal distribution in mice with disorganization of thymic medullary epithelium. J Histochem Cytochem. 2009 Apr;57(4):373-82. Epub 2008 Dec 24.


We examined the expression of mesenchymal markers: pan-mesenchymal marker ER-TR7, desmin, alpha-smooth muscle actin (alpha-SMA), and alpha- and beta-chain of platelet-derived growth factor receptor (PDGFRalpha, PDGFRbeta) in thymi of normal adult mice.
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20055602 Alaggio R, Collini P, Randall L, Barnette P, Smith L, Coffin CM: High Grade Pleomorphic Undifferentiated Sarcomas In Children: A Clinicopathologic Study Of 10 Cases and review of literature. Pediatr Dev Pathol. 2010 Jan 7.


CD68 and desmin were positive in 2 cases each, SMA in 4, S100 in one.
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18240955 Bababeygy SR, Cheshier SH, Hou LC, Higgins DM, Weissman IL, Tse VC: Hematopoietic stem cell-derived pericytic cells in brain tumor angio-architecture. Stem Cells Dev. 2008 Feb;17(1):11-8.


LT-HSC-derived GFP+ cells express the pericyte progenitor marker, platelet-derived growth factor receptor-beta (PDGFR beta), as well as mature perictyte markers such as nerve/glial antigen 2 proteoglycan (NG2), alpha-smooth muscle actin (alpha SMA), and desmin.
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