| Name | PI3K |
|---|---|
| Synonyms | GRB 1; PI3K; GRB1; PI3 kinase p85 subunit alpha; Phosphatidyl inositol 3 kinase associated p85 alpha; Phosphatidylinositol 3 kinase regulatory subunit alpha; PtdIns 3 kinase p85 alpha… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20015942 | Lee YJ, Han HJ: Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3{beta}, Snail1, and {beta}-catenin in renal proximal tubule cells. Am J Physiol Renal Physiol. 2009 Dec 16. |
7(0,0,0,7) | Details |
| 19271115 | Masamune A, Shimosegawa T: Signal transduction in pancreatic stellate cells. J Gastroenterol. 2009;44(4):249-60. Epub 2009 Mar 7. Signaling molecules, such as peroxisome proliferator-activated receptor-gamma (PPAR-gamma), Rho/Rho kinase, nuclear factor-kappaB (NF-kappaB), mitogen-activated protein (MAP) kinases, phosphatidylinositol 3 kinase (PI3K), Sma- and Mad-related proteins, and reactive species (ROS) might be candidates for the development of anti-fibrosis therapy targeting PSCs. |
6(0,0,1,1) | Details |
| 20212046 | Zhang L, Xie P, Wang J, Yang Q, Fang C, Zhou S, Li J: Impaired peroxisome proliferator-activated receptor-{gamma} contributes to phenotypic modulation of vascular smooth muscle cells during hypertension. J Biol Chem. 2010 Mar 8. Increased activation of phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling was observed in SHR-derived VSMCs. |
6(0,0,0,6) | Details |
| 19519177 | He Z, Zhu Y, Jiang H: Toll-like receptor 4 mediates lipopolysaccharide-induced collagen secretion by phosphoinositide3-kinase-Akt pathway in fibroblasts during acute lung injury. J Recept Signal Transduct Res. 2009;29(2):119-25. We reported that LPS was able to directly induce secretion of collagen in mouse lung fibroblasts via activation of phosphoinositide3-kinase-Akt (PI3K-Akt) pathway through toll-like receptor 4 (TLR4) in vitro. |
2(0,0,0,2) | Details |
| 20177740 | Deng B, Yang X, Liu J, He F, Zhu Z, Zhang C: Focal adhesion kinase mediates TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition in vitro. Mol Cell Biochem. 2010 Feb 23. TGF-beta1-induced down-regulation of E-cadherin was recovered by a PI3K/Akt inhibitor, LY294002, without affecting the expression of FAK. |
1(0,0,0,1) | Details |
| 19929904 | Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V, Brenner DA, Gines P, Bataller R: Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int. 2010 Jan;30(1):31-41. Epub 2009 Nov 19. The effects of Huh7 cells on cell proliferation and migration were mediated mainly by PI3K/AKT activation. |
1(0,0,0,1) | Details |
| 19351384 | Millino C, Fanin M, Vettori A, Laveder P, Mostacciuolo ML, Angelini C, Lanfranchi G: Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy. BMC Med. 2009 Apr 7;7:14. The expression pattern of gene networks involved in atrophy signaling was completed by qRT-PCR, showing that specific pathways are involved, namely IGF/PI3K/Akt, TNF-alpha/p38 MAPK and Ras/ERK pathways. |
1(0,0,0,1) | Details |