Protein Information

Name estrogen receptor
Synonyms ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17615152 Cheng J, Zhang C, Shapiro DJ: A functional serine 118 phosphorylation site in estrogen receptor-alpha is required for down-regulation of gene expression by 17beta-estradiol and 4-hydroxytamoxifen. Endocrinology. 2007 Oct;148(10):4634-41. Epub 2007 Jul 5.

In contrast, for Sma and mothers against decapentaplegic-3-related, which is down-regulated by E (2) and not OHT, the S118A mutation had little effect.
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19451194 Mehasseb MK, Bell SC, Habiba MA: The effects of tamoxifen and estradiol on myometrial differentiation and organization during early uterine development in the CD1 mouse. Reproduction. 2009 Aug;138(2):341-50. Epub 2009 May 18.


We examined the sections histologically, using image analysis and immunohistochemistry for alpha-smooth muscle actin (alpha-SMA), desmin, vimentin, laminin, fibronectin, and estrogen receptor-alpha.
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19184024 Bocker W, Hungermann D, Decker T: [Anatomy of the breast] . Pathologe. 2009 Feb;30(1):6-12.


Only some of the glandular cells contain estrogen receptors.
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18677391 Huang YJ, Huang X, Shi XY, Lu J: [Pathological characteristics mixed epithelial and stromal tumor of kidney]. Beijing Da Xue Xue Bao. 2008 Aug 18;40(4):415-8.


Immunohistochemical staining revealed that the epithelial components were positive for AE1/AE3 and focally positive for estrogen receptor (ER),progesterone receptor (PR), CD10 and Vimentin, whereas the stromal components were positive for ER, PR, Desmin and smooth muscle actin (SMA).
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19277704 Tzelepi V, Grivas P, Kefalopoulou Z, Kalofonos H, Varakis JN, Melachrinou M, Sotiropoulou-Bonikou G: Estrogen signaling in colorectal carcinoma microenvironment: expression of ERbeta1, AIB-1, and TIF-2 is upregulated in cancer-associated myofibroblasts and correlates with disease progression. Virchows Arch. 2009 Apr;454(4):389-99. Epub 2009 Mar 7.


Expression of ERalpha, ERbeta1, and the ER coregulators, amplified in breast cancer-1 (AIB-1) and transcriptional intermediary factor 2 (TIF-2), was evaluated in myofibroblasts of 107 colorectal carcinomas, 77 paired samples of normal mucosa, and 29 adenomas by immunohistochemistry.
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18807040 Mainka P, Kahlert S, Kirchner T, Mayr D, Diebold J: [Basal and myoepithelial phenotype of metastatic mammary carcinomas. Pathologe. 2008 Nov;29 Suppl 2:363-9.


METHODS: Paraffin-embedded material from 244 primary breast carcinomas of patients with subsequent metastatic disease was stained immunohistochemically for CK 5/6, CK14, smooth-muscle actin, p63, estrogen receptor and progesterone receptor.
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