Protein Information

Name hnRNP Q
Synonyms GRY RBP; Glycine and tyrosine rich RNA binding protein; HNRPQ; HNRPQ 1; HNRPQ1; Heterogeneous nuclear ribonucleoprotein Q; NS1 associated protein 1; NSAP 1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18794368 Chen HH, Chang JG, Lu RM, Peng TY, Tarn WY: The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene. Mol Cell Biol. 2008 Nov;28(22):6929-38. Epub 2008 Sep 15.

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19430205 Singh NN, Shishimorova M, Cao LC, Gangwani L, Singh RN: A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy. RNA Biol. 2009 Jul;6(3):341-50. Epub 2009 Jul 14.


We further demonstrate that a single low nanomolar dose of this 8-mer ASO substantially increases the levels of SMN and a host of factors including Gemin 2, Gemin 8, ZPR1, hnRNP Q and Tra2-beta1 known to be down-regulated in SMA.
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