Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18325702 Mingorance C, Andriantsitohaina R, Alvarez de Sotomayor M: Cedrelopsis grevei improves endothelial vasodilatation in aged rats through an increase of NO participation. J Ethnopharmacol. 2008 Apr 17;117(1):76-83. Epub 2008 Feb 2.


SBP was evaluated by tail-cuff and vascular reactivity and endothelial vasodilatation of both aortae and small mesenteric arteries (SMA) were assessed by acetylcholine (ACh) in the presence or in the absence of either reactive oxygen species (ROS) scavengers superoxide dismutase (SOD) plus catalase or the nitric oxide synthase inhibitor, NG-L-arginine methyl ester (L-NAME).
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19217652 Aksu B, Umit H, Kanter M, Guzel A, Aktas C, Civelek S, Uzun H: Effects of methylene blue in reducing cholestatic oxidative stress and hepatic damage after bile-duct ligation in rats. Acta Histochem. 2010 May;112(3):259-69. Epub 2009 Feb 14.


Malondialdehyde, nitric oxide and superoxide dismutase were measured to indicate the oxidative status in the liver tissue.
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20047646 Reese S, Vidyasagar A, Jacobson L, Acun Z, Esnault S, Hullett D, Malter JS, Djamali A: The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair. 2010 Jan 4;3:1.


Juglone also reduced EMT (alpha-SMA and E-cadherin dual staining) and oxidative stress (Mn superoxide dismutase (SOD) and NAPDH oxidase 2 (Nox-2) dual staining) in the obstructed kidney.
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20139407 Sanchez-Pozos K, Lee-Montiel F, Perez-Villalva R, Uribe N, Gamba G, Bazan-Perkins B, Bobadilla NA: Polymerized type I collagen reduces chronic cyclosporine nephrotoxicity. Nephrol Dial Transplant. 2010 Feb 5.


The mRNA expression levels of transforming growth factor-beta (TGF-beta), kidney injury molecule (Kim-1), alpha-smooth muscle actin (alpha-SMA), glutathione peroxidase, catalase and Cu/Zn superoxide dismutase (SOD) as well as MnSOD were assessed.
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19249331 Fang J, Seki T, Maeda H: Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev. 2009 Apr 28;61(4):290-302. Epub 2009 Feb 26.


Such therapeutic strategies are described in this article, that includes polymeric superoxide dismutase (SOD) (e.g., pyran copolymer-SOD), xanthine oxidase (XO) inhibitor as we developed water soluble form of 4-amino-6-hydroxypyrazolo [3,4-d] pyrimidine (AHPP), heme oxygenase-1 (HO-1) inducers (e.g., hemin and its polymeric form), and other antioxidants or radical scavengers (e.g., canolol).
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20232302 Roson MI, Della Penna SL, Cao G, Gorzalczany S, Pandolfo M, Toblli JE, Fernandez BE: Different protective actions of losartan and tempol on the renal inflammatory response to acute sodium overload. J Cell Physiol. 2010 Mar 15.


Sprague-Dawley rats were infused for 2 h with isotonic saline solution (Control group) and with hypertonic saline solution alone (Na group), plus the AT1 receptor antagonist losartan (10 mg kg (-1) in bolus) (Na-Los group), or plus the superoxide dismutase mimetic tempol (0.5 mg min (-1) kg (-1)) (Na-Temp group).
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18812033 Yuan LP, Chen FH, Ling L, Bo H, Chen ZW, Li F, Zhong MM, Xia LJ: Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats. J Pharm Pharmacol. 2008 Oct;60(10):1393-402.


In addition, TFB markedly inhibited CCl4-induced lipid peroxidation and enhanced the activity of the antioxidant enzymes superoxide dismutase and glutathione peroxidase.
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19345372 Liu KX, Li YS, Huang WQ, Li C, Liu JX, Li Y: Immediate but not delayed postconditioning during reperfusion attenuates acute lung injury induced by intestinal ischemia/reperfusion in rats: comparison with ischemic preconditioning. J Surg Res. 2009 Nov;157(1):e55-62. Epub 2008 Dec 13.


RESULTS: Histologic results showed severe damage in rat lungs in the injury group evidenced by increased lung wet/dry weight ratio and pulmonary permeability index, which was accompanied by increases in the levels of plasma TNFalpha and IL-6, the pulmonary malondialdehyde (MDA), and the pulmonary myeloperoxidase (MPO) activity and a decrease in superoxide dismutase (SOD) activity.
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17973934 Zhang BJ, Xu D, Guo Y, Ping J, Chen LB, Wang H: Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors. Clin Exp Pharmacol Physiol. 2008 Mar;35(3):303-9. Epub 2007 Oct 30.


Serum levels of alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST), hepatic activity of superoxide dismutase (SOD) and hepatic malondialdehyde (MDA) and hepatic hydroxyproline (Hyp) content were determined.
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20082249 Chen Y, Chen Q, Lu J, Li FH, Tao YY, Liu CH: Effects of Danggui Buxue Decoction () on lipid peroxidation and MMP-2/9 activities of fibrotic liver in rats. Chin J Integr Med. 2009 Dec;15(6):435-41. Epub 2010 Jan 18.


The liver function including serum alanine aminotransamine (ALT), aspartate transamine (AST), albumin (Alb) and total bilirubin (TBIL), liver triglyceride (TG) and malondialdehyde (MDA) contents, superoxide dismutase (SOD) activity were assayed.
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