Protein Information

Name LPA1 receptor
Synonyms EDG2; EDG 2; EDG2; Edg 2; Endothelial differentiation gene 2; Endothelial differentiation lysophosphatidic acid G protein coupled receptor 2; Gpcr26; LPA receptor 1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18003779 Pradere JP, Klein J, Gres S, Guigne C, Neau E, Valet P, Calise D, Chun J, Bascands JL, Saulnier-Blache JS, Schanstra JP: LPA1 receptor activation promotes renal interstitial fibrosis. . J Am Soc Nephrol. 2007 Dec;18(12):3110-8. Epub 2007 Nov 14.

4(0,0,0,4) Details
20177148 Jeon ES, Heo SC, Lee IH, Choi YJ, Park JH, Choi KU, Park DY, Suh DS, Yoon MS, Kim JH: Ovarian Cancer-Derived Lysophosphatidic Acid Stimulates Secretion of VEGF and SDF-1a from Human Mesenchymal Stem Cells. Exp Mol Med. 2010 Feb 22.


Pretreatment with the LPA receptor inhibitor Ki16425 or short hairpin RNA lentiviral silencing of the LPA1 receptor abrogated the cancer CM-stimulated expression of a-SMA, SDF-1, and VEGF from hASCs.
1(0,0,0,1) Details