| Name | serum response factor |
|---|---|
| Synonyms | C FOS serum response element binding factor; MCM 1; MCM1; SRF; Serum response factor; serum response factor (c fos serum response element binding transcription factor); Serum response factors; serum response factor (c fos serum response element binding transcription factor)s |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18337547 | Elberg G, Chen L, Elberg D, Chan MD, Logan CJ, Turman MA: MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells. Am J Physiol Renal Physiol. 2008 May;294(5):F1116-28. Epub 2008 Mar 12. We hypothesized that a coactivator of the serum response factor (SRF), megakaryoblastic leukemia factor-1 (MKL1), stimulates alpha-smooth muscle actin (alpha-SMA) transcription in primary cultures of renal tubular epithelial cells (RTC), which convert into myofibroblasts on treatment with TGF-beta1. |
1(0,0,0,1) | Details |
| 19269978 | Makarenkova HP, Gonzalez KN, Kiosses WB, Meech R: Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene. J Biol Chem. 2009 May 29;284(22):14866-74. Epub 2009 Mar 5. We also show that Barx2, MyoD, and serum response factor simultaneously occupy the SMA promoter in cells and that Barx2 interacts with MyoD. |
1(0,0,0,1) | Details |
| 20071339 | Chan MW, Chaudary F, Lee W, Copeland JW, McCulloch CA: Force-induced myofibroblast differentiation through collagen receptors is dependent on mammalian diaphanous (mDia). J Biol Chem. 2010 Mar 19;285(12):9273-81. Epub 2010 Jan 13. The expression of the transcriptional co-activator of SMA, serum response factor, was reduced by 50% after siRNA knockdown of mDia or by 100% in cells transfected with catalytically inactive mDia. |
1(0,0,0,1) | Details |
| 19608972 | Grabski AD, Shimizu T, Deou J, Mahoney WM Jr, Reidy MA, Daum G: Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1644-50. Epub 2009 Jul 16. Chromatin immunoprecipitation assays suggest that S1P-induced recruitment of serum response factor to the SMA promoter and enhancer largely depends on S1P2R. |
1(0,0,0,1) | Details |
| 19940066 | Pattabiraman PP, Rao PV: Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 2010 Mar;298(3):C749-63. Epub 2009 Nov 25. RhoAV14, lysophosphatidic acid, and TGF-beta (2) stimulated significant increases in Erk1/2 phosphorylation, paralleled by profound increases in fibronectin, serum response factor (SRF), and alpha-SMA expression. |
1(0,0,0,1) | Details |
| 20016221 | Sebe A, Erdei Z, Varga K, Bodor C, Mucsi I, Rosivall L: Cdc42 regulates myocardin-related transcription factor nuclear shuttling and alpha-smooth muscle actin promoter activity during renal tubular epithelial-mesenchymal transition. Nephron Exp Nephrol. 2010;114(3):e117-25. Epub 2009 Dec 16. The Rho-Rho kinase-myosin light chain-myocardin-related transcription factor (MRTF)-serum response factor (SRF) pathway and Rac1, p21-activated kinase (PAK) and p38 were described as important regulators of MRTF localization and SMA expression. |
1(0,0,0,1) | Details |
| 20199810 | Chou MT, Chang SN, Ke C, Chang HI, Sung ML, Kuo HC, Chen CN: The proliferation and differentiation of placental-derived multipotent cells into smooth muscle cells on fibrillar collagen. Biomaterials. 2010 May;31(15):4367-75. Epub 2010 Mar 3. By using specific inhibitors and small interfering RNA (siRNA), we demonstrated that p38 MAPK pathway and serum response factor (SRF)-DNA binding activity is critical for the polymerized collagen-induced PDMC differentiation into SMCs. |
1(0,0,0,1) | Details |