Protein Information

Name MMP1
Synonyms CLG; CLGN; Fibroblast collagenase; Interstitial collagenase; Interstitial collagenase precursor; MMP 1; MMP1; MMP1 protein…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19250650 Urtasun R, Cubero FJ, Vera M, Nieto N: Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology. 2009 Apr;136(4):1410-22

There was a time- and dose-dependent down-regulation of collagen I and alpha-Sma proteins and up-regulation of MMP1 and TNFalpha, indicating decreased HSC activation.
34(0,1,1,4) Details
18323784 Bujor AM, Pannu J, Bu S, Smith EA, Muise-Helmericks RC, Trojanowska M: Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. J Invest Dermatol. 2008 Aug;128(8):1906-14. Epub 2008 Mar 6.

4(0,0,0,4) Details
19224893 Wang Z, Chen C, Finger SN, Kwajah S, Jung M, Schwarz H, Swanson N, Lareu FF, Raghunath M: Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis?. e1-4. Epub 2009 Jan 6.


However, MMP1 activity and TIMP1 production was modulated without a clear fibrolytic effect.
1(0,0,0,1) Details