| Name | p38 |
|---|---|
| Synonyms | AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18154735 | Sebe A, Masszi A, Zulys M, Yeung T, Speight P, Rotstein OD, Nakano H, Mucsi I, Szaszi K, Kapus A: Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor. FEBS Lett. 2008 Jan 23;582(2):291-8. Epub 2007 Dec 27. Contact disruption by low-Ca (2+) medium (LCM) activated Rac, PAK and p38 MAPK, and triggered the nuclear accumulation of myocardin-related transcription factor (MRTF), an inducer of the SMA promoter. |
83(1,1,1,3) | Details |
| 19082432 | Fang KY, Shi MJ, Xiao Y, Gui HZ, Guo B, Zhang GZ: [p38 MAPK mediates high -induced renal tubular epithelial-mesenchymal transition.]. Sheng Li Xue Bao. 2008 Dec 25;60(6):759-66. |
8(0,0,0,8) | Details |
| 19567170 | Deng ZY, Li J, Jin Y, Chen XL, Lu XW: Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis. Chin Med J. 2009 Jun 20;122(12):1449-54. |
5(0,0,0,5) | Details |
| 18669633 | Ding Q, Gladson CL, Wu H, Hayasaka H, Olman MA: Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner. J Biol Chem. 2008 Oct 3;283(40):26839-49. Epub 2008 Jul 31. Although both ERK and p38 MAPK activation is required for maximal TGF-beta1-induced alpha-SMA expression, ERK is the major signaling intermediate in cells that express FAK. |
3(0,0,0,3) | Details |
| 19648294 | Farooq F, Balabanian S, Liu X, Holcik M, MacKenzie A: p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR. Hum Mol Genet. 2009 Nov 1;18(21):4035-45. Epub 2009 Jul 31. |
3(0,0,0,3) | Details |
| 20016221 | Sebe A, Erdei Z, Varga K, Bodor C, Mucsi I, Rosivall L: Cdc42 regulates myocardin-related transcription factor nuclear shuttling and alpha-smooth muscle actin promoter activity during renal tubular epithelial-mesenchymal transition. Nephron Exp Nephrol. 2010;114(3):e117-25. Epub 2009 Dec 16. The Rho-Rho kinase-myosin light chain-myocardin-related transcription factor (MRTF)-serum response factor (SRF) pathway and Rac1, p21-activated kinase (PAK) and p38 were described as important regulators of MRTF localization and SMA expression. |
3(0,0,0,3) | Details |
| 18421080 | Meyer-Ter-Vehn T, Katzenberger B, Han H, Grehn F, Schlunck G: Lovastatin inhibits TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3955-60. Epub 2008 Apr 17. Phosphorylation of the signaling proteins Smad-2/3 and p38 were detected by Western blot, and Smad-2/3 localization was determined by confocal immunofluorescence microscopy. |
2(0,0,0,2) | Details |
| 19376089 | Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szerszen M: supplementation attenuates - and -induced liver stellate cell activation by inhibiting reactive species (ROS) production and by influencing intracellular signaling. Biochem Pharmacol. 2009 Aug 1;78(3):301-14. Epub 2009 Apr 17. Intracellular signals such as nuclear factor-kappaB (NFkappaB), C-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) induced by and its metabolite were also assessed. |
2(0,0,0,2) | Details |
| 17933841 | Li M, Hering-Smith KS, Simon EE, Batuman V: Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells. Nephrol Dial Transplant. 2008 Mar;23(3):860-70. Epub 2007 Oct 12. LC-induced EMT and the secretions of IL-6 and MCP-1 were, however, markedly attenuated by p38 MAPK interference. |
2(0,0,0,2) | Details |
| 19351384 | Millino C, Fanin M, Vettori A, Laveder P, Mostacciuolo ML, Angelini C, Lanfranchi G: Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy. BMC Med. 2009 Apr 7;7:14. The expression pattern of gene networks involved in atrophy signaling was completed by qRT-PCR, showing that specific pathways are involved, namely IGF/PI3K/Akt, TNF-alpha/p38 MAPK and Ras/ERK pathways. |
2(0,0,0,2) | Details |
| 19287196 | Yun DH, Song HY, Lee MJ, Kim MR, Kim MY, Lee JS, Kim JH: A (2) modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells. Exp Mol Med. 2009 Jan 31;41(1):17-24. U46619 activated ERK and p38 MAPK, and pretreatment of the cells with the MEK inhibitor U0126 or the p38 MAPK inhibitor SB202190 abrogated the U46619-induced migration, proliferation, and alpha-SMA expression. |
2(0,0,0,2) | Details |
| 17579091 | Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R: Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. J Immunol. 2007 Jul 1;179(1):682-90. Blocking p38 MAPK resulted in reduced alpha-SMA expression by Unc119 suggesting that the p38 pathway regulates Unc119-induced myofibroblast differentiation. |
1(0,0,0,1) | Details |
| 19175832 | Lin YL, Wu CF, Huang YT: Effects of rhubarb on migration of rat hepatic stellate cells. J Gastroenterol Hepatol. 2009 Mar;24(3):453-61. Epub 2008 Oct 23. Phosphorylations of Smad2/3 and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK) 1/2, p38, and c-jun N-terminal kinase (JNK), were analyzed with Western blotting. |
1(0,0,0,1) | Details |
| 19470381 | Wu M, Han M, Li J, Xu X, Li T, Que L, Ha T, Li C, Chen Q, Li Y: 17beta- inhibits angiotensin II-induced cardiac myofibroblast differentiation. Eur J Pharmacol. 2009 Aug 15;616(1-3):155-9. Epub 2009 May 24. Pretreatment of 17beta- significantly reduced angiotensin II-increased levels of phospho-p38 mitogen-activated protein kinase (MAPK) by 40% and nuclear factor-kappaB (NF-kappaB) binding activity in cardiac fibroblasts by 55%. |
1(0,0,0,1) | Details |
| 19723340 | Weng TC, Shen CC, Chiu YT, Lin YL, Kuo CD, Huang YT: Inhibitory effects of armepavine against hepatic fibrosis in rats. J Biomed Sci. 2009 Sep 2;16:78. Arm also suppressed TNF-alpha-induced collagen collagen deposition, NFkappaB activation and MAPK (p38, ERK1/2, and JNK) phosphorylations. |
1(0,0,0,1) | Details |
| 20062961 | Vercelino R, Crespo I, de Souza GF, Cuevas MJ, de Oliveira MG, Marroni NP, Gonzalez-Gallego J, Tunon MJ: S-nitroso- attenuates liver fibrosis in cirrhotic rats. J Mol Med. 2010 Apr;88(4):401-11. Epub 2010 Jan 9. These effects were accompanied by inhibited activation of extracellular signal-regulated kinases, Jun amino-terminal kinases, p38 and Akt. |
1(0,0,0,1) | Details |
| 18802055 | Al-Salleeh F, Petro TM: Promoter analysis reveals critical roles for SMAD-3 and ATF-2 in expression of IL-23 p19 in macrophages. J Immunol. 2008 Oct 1;181(7):4523-33. We identified potential binding sites for IFN response factor (IRF)-3 (nt -734 to -731), Sma- and Mad-related protein (SMAD)-3 (nt -584 to -581), activating transcription factor (ATF)-2 (nt -571 to -568), IRF-7 (nt -533 to-525), and NF-kappaB (nt -215 to -209) in the murine p19 promoter. |
0(0,0,0,0) | Details |