| Name | fibronectin |
|---|---|
| Synonyms | CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18996287 | Mazlyzam AL, Aminuddin BS, Saim L, Ruszymah BH: Human serum is an advantageous supplement for human dermal fibroblast expansion: clinical implications for tissue engineering of skin. Arch Med Res. 2008 Nov;39(8):743-52. Gene expression levels by quantitative reverse transcriptase-polymerose chain reaction (RT-PCR) showed cultured fibroblasts with HS supplementation maintains expression of collagen type I collagen, increased expression of type III collagen and fibronectin and reduced expression of alpha-smooth muscle actin (alpha-SMA) compared to FBS. |
2(0,0,0,2) | Details |
| 19557718 | Xu Y, Wan J, Jiang D, Wu X: BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. Beijing Da Xue Xue Bao. 2008 Oct 18;40(5):509-13. The expression of alpha-smooth muscle actin (alpha-SMA), E-cadherin, fibronectin, collagen I and connective tissue growth factor (CTGF) was analyzed by immunofluorescence, reverse transcriptase polymerase chain reaction and Western blotting. |
2(0,0,0,2) | Details |
| 19158077 | Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY: RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells. J Biol Chem. 2009 Apr 3;284(14):9426-32. Epub 2009 Jan 21. However, TGF-beta stimulation markedly activates RGC-32 while inducing an EMT, as shown by the induction of smooth muscle alpha-actin (alpha-SMA) and extracellular matrix proteins collagen I and fibronectin, as well as the reduction of epithelial marker E-cadherin. |
2(0,0,0,2) | Details |
| 19907023 | Hindman HB, Swanton JN, Phipps RP, Sime PJ, Huxlin KR: Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro. 762. Using immunohistochemistry and Western blot techniques, Ki-67 staining and relative expression of Thy-1, alpha smooth muscle actin (alpha-SMA), and fibronectin were assessed after stimulation with different TGF-beta1 concentrations. |
2(0,0,0,2) | Details |
| 17989584 | Huisman MA, de Heer E, Ten Dijke P, Grote JJ: Transforming growth factor beta and wound healing in human cholesteatoma. . World J Gastroenterol. 2009 Mar 28;15(12):1431-42. STUDY DESIGN: The expression of TGFbeta, the activated form of its intracellular effector, phosphorylated-Sma-Mad (pSmad) 2, its natural inhibitor, Smad7, and target gene extra domain A-positive fibronectin (EDA-FN) were examined. |
31(0,1,1,1) | Details |
| 18096707 | Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES: An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med. 2008 Mar 15;177(6):638-45. Epub 2007 Dec 20. |
9(0,0,0,9) | Details |
| 19940066 | Pattabiraman PP, Rao PV: Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 2010 Mar;298(3):C749-63. Epub 2009 Nov 25. TM cells expressing RhoAV14 exhibited significant increases in fibronectin, tenascin C, laminin, alpha-smooth muscle actin (alpha-SMA) levels, and matrix assembly in association with increased actin stress fibers and myosin light-chain phosphorylation. |
6(0,0,0,6) | Details |
| 19066060 | Xie XS, Liu HC, Li HJ, Fan JM: [Ginsenoside R (g1) inhibit transdifferentiation in rat renal tubular epethelial cells induced by TGF-beta1]. Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(17):2136-41. The morphology of tubular epithelial-myofibroblast transdifferentiation induced by TGF-beta1 was observed through light microscope. alpha-SMA and E-cadherin protein expression were assessed by immunohistochemistry and western blot analyses. alpha-SMA, collagen I and and fibronectin gene expression were assessed by real-time quantitative chain reaction. |
5(0,0,0,5) | Details |
| 18763191 | Jiang D, Jiang Z, Li Z, Zhang Y: Suppression of the production of extracellular matrix and alpha-smooth muscle actin induced by transforming growth factor-beta1 in fibroblasts of the flexor tendon sheath by hepatocyte growth factor. Scand J Plast Reconstr Surg Hand Surg. 2008;42(4):169-73. We examined the effectiveness of hepatocyte growth factor (HGF) in blocking production of transforming growth factor (TGF)-beta1-induced collagen I, fibronectin, and alpha-smooth muscle actin (alpha-SMA) in the flexor tendon sheath of rabbits in vitro. |
3(0,0,0,3) | Details |
| 19101622 | Xie XS, Yang M, Liu HC, Zuo C, Li HJ, Fan JM: Ginsenoside Rg1, a major active component isolated from Panax notoginseng, restrains tubular epithelial to myofibroblast transition in vitro. J Ethnopharmacol. 2009 Feb 25;122(1):35-41. Epub 2008 Dec 3. Gene expression of alpha-SMA as well as the two major extracellular matrix components collagen I and fibronectin was measured by real-time PCR analysis. |
3(0,0,0,3) | Details |
| 18172101 | Schlunck G, Han H, Wecker T, Kampik D, Meyer-ter-Vehn T, Grehn F: Substrate rigidity modulates cell matrix interactions and protein expression in human trabecular meshwork cells. Postepy Biochem. 2009;55(2):138-44. The subcellular distributions of alpha-SMA and fibronectin were examined by confocal immunofluorescence microscopy. |
3(0,0,0,3) | Details |
| 19053028 | Lu Y, Liu C, Miao X, Xu K, Wu X, Liu C: Increased expression of myo-inositol oxygenase is involved in the tubulointerstitial injury of diabetic nephropathy. Exp Clin Endocrinol Diabetes. 2009 Jun;117(6):257-65. Epub 2008 Dec 3. In addition, alpha-smooth muscle actin (alpha-SMA) and fibronectin levels were increased and E-cadherin levels decreased in the same diabetic kidneys. |
3(0,0,0,3) | Details |
| 19640900 | Pang M, Kothapally J, Mao H, Tolbert E, Ponnusamy M, Chin YE, Zhuang S: Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol. 2010 Jan;21(1):93-102. Epub 2009 Nov 19. In this study, we investigated the effect of trichostatin A (TSA), a specific histone deacetylase (HDAC) inhibitor, on the activation of renal interstitial fibroblasts in a rat renal interstitial fibroblast line (NRK-49F) and the development of renal fibrosis in a murine model of unilateral ureteral obstruction (UUO). alpha-Smooth muscle actin (alpha-SMA) and fibronectin, two hallmarks of fibroblast activation, were highly expressed in cultured NRK-49F cells, and their expression was inhibited in the presence of TSA. |
3(0,0,0,3) | Details |
| 19643931 | Jung GS, Kim MK, Choe MS, Lee KM, Kim HS, Park YJ, Choi HS, Lee KU, Park KG, Lee IK: The orphan nuclear receptor SHP attenuates renal fibrosis. . J Am Soc Nephrol. 2009 Oct;20(10):2162-70. Epub 2009 Jul 30. Here, unilateral ureteral obstruction (UUO) markedly increased the expression of PAI-1, type I collagen, and fibronectin but decreased SHP gene expression. |
3(0,0,0,3) | Details |
| 18931715 | Zhang L, Huang HC, Li JZ, Liu Y: [Sirolimus inhibits the expression of type I collagen and fibronectin in cultured renal cortical myofibroblasts]. Tissue Eng Part A. 2010 Feb 17. |
2(0,0,0,2) | Details |
| 18390195 | Xue H, Chen L, Fan JM, Li Z: [Role of MMP-9 and TIMP-1 in renal tubular epithelial-myofibroblast transdifferentiation]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):34-8. The expression levels of MMP-9, TIMP-1, alpha-smooth muscle actin (alpha-SMA) and fibronectin (FN) were examined by immunohistochemistry staining at each time point. |
1(0,0,0,1) | Details |
| 18596079 | Vidyasagar A, Reese S, Acun Z, Hullett D, Djamali A: HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis. Curr Eye Res. 2007 Oct;32(10):863-70. Real-time PCR analyses showed that HSP27, vimentin, and fibronectin increased whereas E-cadherin mRNA levels decreased. |
1(0,0,0,1) | Details |
| 17641298 | Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S, Yokoyama M: Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1. Am J Respir Cell Mol Biol. 2009 Dec;41(6):722-30. Epub 2009 Mar 13. SPHK inhibitors and small interference RNA (siRNA) targeted SPHK1 decreased alpha-SMA and fibronectin expression up-regulated by TGF-beta1. |
1(0,0,0,1) | Details |
| 18288368 | Fang KY, Lou JL, Xiao Y, Shi MJ, Gui HZ, Guo B, Zhang GZ: [Transforming growth factor-beta1 and Snail1 mediate tubular epithelial-mesenchymal transition in diabetic rats.]. Sheng Li Xue Bao. 2008 Feb 25;60(1):125-34. Immunohistochemical staining and (or) Western blot were employed to determine the expressions of TGF-beta1, Snail1, E-cadherin, alpha-smooth muscle actin (alpha-SMA) and fibronectin (FN) proteins. |
1(0,0,0,1) | Details |
| 18235011 | Dawes LJ, Eldred JA, Anderson IK, Sleeman M, Reddan JR, Duncan G, Wormstone IM: TGF beta-induced contraction is not promoted by fibronectin-fibronectin receptor interaction, or alpha SMA expression. Invest Ophthalmol Vis Sci. 2008 Feb;49(2):650-61. To prevent fibronectin-fibronectin receptor interaction 100 microM RGDS peptide was used. |
2(0,0,0,2) | Details |
| 17646041 | Thijssen S, Lambrichts I, Maringwa J, Van Kerkhove E: Changes in expression of fibrotic markers and histopathological alterations in kidneys of mice chronically exposed to low and high Cd doses. Circulation. 2007 Sep 11;116(11 Suppl):I55-63. Furthermore, the expression of the extracellular matrix (ECM) proteins collagen I and fibronectin, and the myofibroblast/epithelial-to-mesenchymal transition (EMT) marker alfa-smooth muscle actin (alpha-SMA) were studied by means of immunohistochemistry. |
2(0,0,0,2) | Details |
| 18790992 | Ichikawa T, Sugiura H, Koarai A, Yanagisawa S, Kanda M, Hayata A, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M: augments fibroblast-mediated tissue remodeling via myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L800-8. Epub 2008 Sep 12. The releases of transforming growth factor-beta (1) (TGF-beta (1)) and ECM proteins including fibronectin and collagen I were assessed. |
2(0,0,0,2) | Details |
| 17943180 | Thielitz A, Vetter RW, Schultze B, Wrenger S, Simeoni L, Ansorge S, Neubert K, Faust J, Lindenlaub P, Gollnick HP, Reinhold D: Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts. J Invest Dermatol. 2008 Apr;128(4):855-66. Epub 2007 Oct 18. Furthermore, they abrogate the TGF-beta (1)-induced stimulation of collagen synthesis, matrix deposition, and TGF-beta (1) and fibronectin expression. |
1(0,0,0,1) | Details |
| 18471414 | Huan HD, Zhang JH, Zheng SR, Meng WW, Zhang JL: [Dilingdan Decoction prevents renal interstitial fibrosis in a rat model of unilateral ureteral obstruction]. Zhong Xi Yi Jie He Xue Bao. 2008 May;6(5):493-7. The expressions of transforming growth factor-beta1 (TGF-beta1), alpha-smooth muscle actin (alpha-SMA), fibronectin (FN) and laminin (LN) were detected by immunohistochemical method and colored-multimedia pathological image analysis system. |
1(0,0,0,1) | Details |
| 18988920 | Shukla MN, Rose JL, Ray R, Lathrop KL, Ray A, Ray P: Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. Am J Respir Cell Mol Biol. 2009 Jun;40(6):643-53. Epub 2008 Nov 6. We show that HGF markedly antagonizes basal and transforming growth factor (TGF)-beta-induced expression of myofibroblast markers such as alpha-SMA, collagen type 1, and fibronectin in rat alveolar epithelial cells. |
1(0,0,0,1) | Details |
| 20131370 | Johnson BQ, Fox R, Chen X, Thibeault S: Tissue regeneration of the vocal fold using bone marrow mesenchymal stem cells and synthetic extracellular matrix injections in rats. Laryngoscope. 2010 Mar;120(3):537-45. Outcomes measured 1 month after treatment included procollagen-III, fibronectin, synthase-III (HAS3), hyaluronidase (HYAL3), smooth muscle actin (SMA), and transforming growth factor-beta 1 (TGF-beta1) mRNA expression. |
2(0,0,0,2) | Details |
| 19168895 | Sharma A, Mehan MM, Sinha S, Cowden JW, Mohan RR: Trichostatin a inhibits corneal haze in vitro and in vivo. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2695-701. Epub 2009 Jan 24. Real-time PCR, immunoblotting, or immunocytochemistry was used to measure alpha-smooth muscle actin (SMA), fibronectin, and collagen type IV mRNA or protein levels. |
2(0,0,0,2) | Details |
| 19322915 | Brenmoehl J, Miller SN, Hofmann C, Vogl D, Falk W, Scholmerich J, Rogler G: Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Jan;30(1):76-9. METHODS: Primary CLPF cultures were incubated with TGF-beta 1 and analyzed for production of alpha-smooth muscle actin (alpha-SMA), fibronectin (FN) and FN isoforms. |
1(0,0,0,1) | Details |
| 19824469 | Nowak D, Popow-Wozniak A, Raznikiewicz L, Malicka-Blaszkiewicz M: [Actin in the wound healing process] . Am J Respir Cell Mol Biol. 2007 Oct;37(4):395-404. Epub 2007 Jul 19. The regulation of differentiation process depends on many growth factors (especially TGF beta 1), the level of active thymosin beta 4, extracellular matrix proteins--including fibronectin, and also on specificity of microenvironment. |
1(0,0,0,1) | Details |
| 18976289 | Djamali A, Vidyasagar A, Adulla M, Hullett D, Reese S: Nox-2 is a modulator of fibrogenesis in kidney allografts. Am J Transplant. 2009 Jan;9(1):74-82. Epub 2008 Oct 31. Allografts treated with Nox inhibitors (DPI or apocynin) for 1 week showed reduced fibronectin and phospho-Smad2 and increased E-cadherin levels. |
2(0,0,0,2) | Details |
| 17720149 | Burstein B, Qi XY, Yeh YH, Calderone A, Nattel S: Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling. Am J Physiol Renal Physiol. 2009 Oct;297(4):F996-F1005. Epub 2009 Jul 29. Rapidly-paced cardiomyocyte medium increased alpha SMA protein (approximately 55%, p <0.001), collagen-1 (approximately 85%, P <0.05) and fibronectin-1 (approximately 205%, P <0.05) mRNA expression vs. controls. |
2(0,0,0,2) | Details |
| 19516008 | Dawes LJ, Sleeman MA, Anderson IK, Reddan JR, Wormstone IM: TGFbeta/Smad4-dependent and -independent regulation of human lens epithelial cells. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5318-27. Epub 2009 Jun 10. Gene expression of transdifferentiation markers, alpha-smooth muscle actin and fibronectin and the inhibitory Smad, Smad7, in the presence and absence of TGFbeta2 (10 ng/mL) was determined with real-time PCR. |
2(0,0,0,2) | Details |
| 20219823 | Kim J, Kim DS, Park M, Cho HJ, Zervos AS, Bonventre JV, Park KM: Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2010 Mar 10. Furthermore, Omi inhibitor significantly attenuated UUO-induced increases of fibrotic characteristics in the kidney, including the atrophy and dilation of tubules, expansion of the interstitium, and increases in the expression of collagens, a-smooth muscle actin (a-SMA), and fibronectin. |
1(0,0,0,1) | Details |
| 20329614 | Sun RF, Liu LX, Zhang HY: [Effect of tanshinone II on hepatic fibrosis in mice] . Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Nov;29(11):1012-7. Changes of serum levels of alanine aminotransferase (ALT) and lactate dehydrogenase (LDH), histopathology of liver (HE staining), area density of collagen in liver (Masson staining), expressions of alpha-smooth muscle actin (alpha-SMA), collagen I , fibronectin (FN), transforming growth factor-beta1 (TGF-beta1), Smad3 and IGFBP7 in liver (by immunohiStochemistry), liver content of FN, Smad3 and IGFBP7 (by Western blot), and the hepatocyte apoptosis (by TUNEL) were observed. |
1(0,0,0,1) | Details |
| 18274641 | Wang W, Liu F, Chen N: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists attenuate the profibrotic response induced by TGF-beta1 in renal interstitial fibroblasts. Mediators Inflamm. 2007;2007:62641. METHODS: In rat renal interstitial fibroblasts (NRK/49F), the mRNA expression of TGF-beta1-induced alpha-smooth muscle actin (alpha-SMA), connective tissue growth factor (CTGF), fibronectin (FN) and collagen type III (Col III) were observed by reverse transcriptase-polymerase chain reaction (RT-PCR). |
1(0,0,0,1) | Details |
| 20112425 | Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY: Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology. 2009 Nov 30. Further study found that EIF5A2 was able to induce epithelial-mesenchymal transition (EMT), a key event in tumor invasion and metastasis, characterized by down-regulation of epithelial markers (E-cadherin and beta-catenin) and up-regulation of mesenchymal markers (fibronectin, N-cadherin, alpha-SMA, and vimentin). |
1(0,0,0,1) | Details |
| 18400254 | Qiu X, Montgomery E, Sun B: Inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma: a comparative study of clinicopathologic features and further observations on the immunohistochemical profile of myofibroblasts. Am J Physiol Renal Physiol. 2008 Sep;295(3):F707-16. Epub 2008 Jul 2. The primary antibodies used in this study were specific for the ultrastructural subcellular components: (1) *-smooth muscle actin (*-SMA), muscle-specific actin (MSA), calponin, and h-caldesmon for myofilaments; (2) fibronectin for fibronexus; (3) laminin for basal lamina; (4) desmin and cytokeratin for intermediate filaments. |
2(0,0,0,2) | Details |
| 19543302 | Yan JD, Yang S, Zhang J, Zhu TH: BMP6 reverses TGF-beta1-induced changes in HK-2 cells: implications for the treatment of renal fibrosis. Acta Pharmacol Sin. 2009 Jul;30(7):994-1000. Epub 2009 Jun 22. The expression of fibronectin, collagen IV, matrix metalloproteinases 2 (MMP-2), and tissue inhibitors of matrix metalloproteinases 2 (TIMP-2) were analyzed using RT-PCR. |
2(0,0,0,2) | Details |
| 18827016 | Leask A, Shi-Wen X, Khan K, Chen Y, Holmes A, Eastwood M, Denton CP, Black CM, Abraham DJ: Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function. J Cell Sci. 2008 Oct 15;121(Pt 20):3459-67. Epub 2008 Sep 30. Moreover, both in the presence and absence of TGFbeta, dermal fibroblasts from PKCepsilon-/- mice cultured on fibronectin show impaired abilities to form ;supermature' focal adhesions and alpha-SMA stress fibers, and reduced pro-fibrotic gene expression. |
1(0,0,0,1) | Details |
| 19926889 | Bondi CD, Manickam N, Lee DY, Block K, Gorin Y, Abboud HE, Barnes JL: NAD (P) H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. Pulm Pharmacol Ther. 2009 Dec;22(6):487-91. Epub 2009 Apr 22. TGF-beta1 expression closely associates with activation and conversion of fibroblasts to a myofibroblast phenotype and synthesis of an alternatively spliced cellular fibronectin variant, Fn-ED-A. |
1(0,0,0,1) | Details |
| 18036812 | Yamate J, Ogata K, Yuasa T, Kuwamura M, Takenaka S, Kumagai D, Itoh K, LaMarre J: Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells. Eur J Cancer. 2007 Dec;43(18):2747-56. TGF-beta1-treated MT-9 revealed increased numbers of alpha-SMA-immunopositive cells, and enhanced protein levels of alpha-SMA and fibronectin, indicating myofibrogenesis. |
1(0,0,0,1) | Details |
| 19393328 | Sugiura H, Ichikawa T, Liu X, Kobayashi T, Wang XQ, Kawasaki S, Togo S, Kamio K, Mao L, Ann Y, Ichinose M, Rennard SI: N-acetyl- inhibits TGF-beta1-induced profibrotic responses in fibroblasts. Laryngoscope. 2008 Jan;118(1):94-8. OBJECTIVES: The aim of this study was to evaluate whether the antioxidant N-acetyl- (NAC) can affect TGF-beta (1)-mediated tissue remodeling in fibroblasts or modulate the production of fibronectin and vascular endothelial growth factor (VEGF) which are believed to be important mediators of tissue repair and remodeling. |
2(0,0,0,2) | Details |
| 20163211 | Cheng MT, Liu CL, Chen TH, Lee OK: Comparison of Potentials between Stem Cells Isolated from Human Anterior Cruciate Ligament and Bone Marrow for Ligament Tissue Engineering. World J Urol. 2009 Mar 15. TGF-beta1 treatment significantly increased the expression of type I collagen, type III collagen, fibronectin, and alpha-smooth muscle actin (alpha-SMA) in LSCs, but TGF-beta1 only up-regulated type I collagen and tenascin-c on BMSCs. |
1(0,0,0,1) | Details |
| 20339928 | Jiang Y, Ding G, Lu S: Behavior of dermal fibroblasts on microdot arrays yields insight into wound healing mechanisms. Mol Biol Rep. 2010 Mar 26. Dermal fibroblasts were cultured on micro-patterned silicone elastomer substrates designed to enforce cell adhesion only to fibronectin microdots. |
1(0,0,0,1) | Details |
| 19288266 | Grande MT, Arevalo M, Nunez A, Cannata-Andia JB, Santos E, Lopez-Novoa JM: Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation. Hum Pathol. 2008 Jun;39(6):846-56. Epub 2008 Apr 8. Fibronectin, alpha-smooth muscle actin, cleaved caspase-3, ki-67, Ras-GTP, pERK, and pAkt expression was analyzed by western blot and/or immunohistochemistry. |
1(0,0,0,1) | Details |
| 19024302 | You GQ, Fu P, Xie XS, Liu F, Li J: [Effects of piperazine on TGF-beta1-induced renal interstitial fibroblast activation]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Sep;39(5):736-9 The levels of collagen type I (Col I) and fibronectin (FN) protein expression were examined by Enzyme Linked Immunosorbent Assay (ELISA). |
1(0,0,0,1) | Details |
| 17898292 | Gotoh N, Perdue NR, Matsushima H, Sage EH, Yan Q, Clark JI: An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4679-87. Expression of the EMT markers, collagen type I, fibronectin, and alpha-smooth muscle actin were assessed using immunocytochemistry or Western immunoblots. |
1(0,0,0,1) | Details |
| 19598300 | Liu LX, Huang S, Zhang QQ, Liu Y, Zhang DM, Guo XH, Han DW: Insulin-like growth factor binding protein-7 induces activation and transdifferentiation of hepatic stellate cells in vitro. World J Gastroenterol. 2009 Jul 14;15(26):3246-53. In addition, fibronectin, collagen I and alpha-SMA also showed enhanced expression in accordance with the transdifferentiation process in a dose-dependent manner to some extent. |
1(0,0,0,1) | Details |
| 18094035 | Wang L, Lee JY, Kwak JH, He Y, Kim SI, Choi ME: Protective effects of low-dose against renal fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2008 Mar;294(3):F508-17. Epub 2007 Dec 19. Additionally, in vitro CO exposure markedly inhibited TGF-beta (1)-induced expression of alpha-SMA, collagen, and fibronectin in renal proximal tubular epithelial cells. |
1(0,0,0,1) | Details |
| 18055804 | Honjo M, Tanihara H, Kameda T, Kawaji T, Yoshimura N, Araie M: Potential role of Rho-associated protein kinase inhibitor Y-27632 in glaucoma filtration surgery. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):262-9. The cell adhesion assay showed that Y-27632 promoted adhesiveness to both fibronectin and collagen type I. |
1(0,0,0,1) | Details |
| 18291634 | Kennedy L, Shi-Wen X, Carter DE, Abraham DJ, Leask A: Fibroblast adhesion results in the induction of a matrix remodeling gene expression program. Matrix Biol. 2008 May;27(4):274-81. Epub 2008 Jan 26. Adhesion of fibroblasts to fibronectin, a component of the provisional matrix deposited in the initial phases of tissue repair, also resulted in the induction of CCN2, alpha-SMA and type I collagen mRNAs. |
1(0,0,0,1) | Details |
| 18988918 | Sugiura H, Ichikawa T, Koarai A, Yanagisawa S, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Ichinose M: Activation of Toll-like receptor 3 augments myofibroblast differentiation. Am J Respir Cell Mol Biol. 2009 Jun;40(6):654-62. Epub 2008 Nov 6. The production of fibronectin and collagen I expression were significantly increased by poly (I:C) (P < 0.01) and they were inhibited by anti-TGF-beta antibody. |
1(0,0,0,1) | Details |
| 17633463 | Zhang MZ, Zhang MY, Zhao S, Duan JZ, Zhang YQ, Zuo CX, Cheng XY, Duan HJ: [Effect of JAK/STAT pathway activation on high -induced transdifferentiation in renal proximal tubular epithelial cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Jun;29(3):364-9. The contents of TGF-B1, fibronectin and type I collagen in the supernatants of the cultured HKC were detected by enzyme-linked immunosorbent assay (ELISA). |
1(0,0,0,1) | Details |
| 18550647 | Ardura JA, Berruguete R, Ramila D, Alvarez-Arroyo MV, Esbrit P: Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney. Am J Physiol Renal Physiol. 2008 Aug;295(2):F415-25. Epub 2008 Jun 11. These changes were associated with higher fibronectin mRNA expression and alpha-smooth muscle actin (alpha-SMA) and integrin-linked kinase (ILK) immunostaining and lower apoptotic tubulointerstitial cells in the mouse obstructed kidney than in control littermates. |
1(0,0,0,1) | Details |
| 19193779 | Yu MA, Shin KS, Kim JH, Kim YI, Chung SS, Park SH, Kim YL, Kang DH: HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium. J Am Soc Nephrol. 2009 Mar;20(3):567-81. Epub 2009 Feb 4. We found that high concentrations of induced epithelial-to-mesenchymal transition (EMT) of HPMC, suggested by decreased expression of E-cadherin and increased expression of alpha-smooth muscle actin, fibronectin, and type I collagen and by increased cell migration. |
1(0,0,0,1) | Details |
| 19384472 | Shiwen X, Rajkumar V, Denton CP, Leask A, Abraham DJ: Pericytes display increased CCN2 expression upon culturing. J Cell Commun Signal. 2009 Mar;3(1):61-4. Epub 2009 Apr 22. The expression of type I collagen, thrombospondin and fibronectin mRNAs was induced by passaging pericytes in culture. |
1(0,0,0,1) | Details |
| 18538087 | Chen TF, Chen M, Qin JH, Wang MY: [Interventional effect of emodin on the expression of intergern linked kinase in tubular epithelial-myofibroblast transdifferentiation]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Jun;24(6):574-6. The secretion of fibronectin (FN) was analyzed by ELISA. |
1(0,0,0,1) | Details |
| 19434765 | Zuo C, Xie XS, Qiu HY, Deng Y, Zhu D, Fan JM: Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-beta in rats with unilateral ureteral obstruction. Invest Ophthalmol Vis Sci. 2010 Apr;51(4):1935-42. Epub 2009 Nov 11. The expressions of fibronectin (FN), type I collagen (colI), hepatocyte growth factor (HGF), transforming growth factor-beta1 (TGF-beta1), and alpha-smooth muscle actin (alpha-SMA) were analyzed by real-time polymerase chain reaction (PCR), immunohistochemistry staining, and Western blot. |
1(0,0,0,1) | Details |
| 19134459 | Chen TF, Chen M, Qin JH, Wang MY: [Interventional effects of emodin on transforming growth factor-beta1/integrin-linked kinase signal way in interleukin-1beta-induced transdifferentiation of rat tubular epithelial-myofibroblasts]. J Nephrol. 2009 May-Jun;22(3):403-10. The secretion of fibronectin (FN) was analyzed by enzyme-linked immunosorbent assay. |
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| 17846326 | Sales VL, Engelmayr GC Jr, Johnson JA Jr, Gao J, Wang Y, Sacks MS, Mayer JE Jr: Protein precoating of elastomeric tissue-engineering scaffolds increased cellularity, enhanced extracellular matrix protein production, and differentially regulated the phenotypes of circulating endothelial progenitor cells. J Zhejiang Univ Sci B. 2009 May;10(5):380-90. METHODS AND RESULTS: Elastomeric poly scaffolds were precoated with laminin, fibronectin, fibrin, collagen types I/III, or elastin. |
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| 19616542 | Del Prete D, Ceol M, Anglani F, Vianello D, Tiralongo E, Valente M, Graziotto R, Bonfante L, Scaparrotta G, Furian L, Rigotti P, Gambaro G, D'Angelo A: Early activation of fibrogenesis in transplanted kidneys: a study on serial renal biopsies. Zhong Xi Yi Jie He Xue Bao. 2009 Jan;7(1):59-64. Morphometric alpha SMA and TGF beta 1 analysis, and Masson's Trichrome staining were performed. mRNA levels of angiotensinogen, renin, ACE, AT1-R, AT2-R, TGF beta 1, BMP-7, Coll III, fibronectin and alpha SMA were analyzed by real-time RT/PCR. |
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| 19286977 | Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ: Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. Exp Mol Pathol. 2009 Oct;87(2):141-5. Epub 2009 Jul 16. We report here that a novel PPARgamma ligand, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), is a potent inhibitor of TGF-beta-stimulated differentiation of human lung fibroblasts to myofibroblasts, and suppresses up-regulation of alpha-smooth muscle actin, fibronectin, collagen, and the novel myofibroblast marker, calponin. |
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| 19451194 | Mehasseb MK, Bell SC, Habiba MA: The effects of tamoxifen and on myometrial differentiation and organization during early uterine development in the CD1 mouse. Reproduction. 2009 Aug;138(2):341-50. Epub 2009 May 18. We examined the sections histologically, using image analysis and immunohistochemistry for alpha-smooth muscle actin (alpha-SMA), desmin, vimentin, laminin, fibronectin, and estrogen receptor-alpha. |
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| 18365870 | Solini A, Santini E, Madec S, Cuccato S, Ferrannini E: Effects of endothelin-1 on fibroblasts from type 2 diabetic patients: Possible role in wound healing and tissue repair. Growth Factors. 2007 Dec;25(6):392-9. We compared the effect of ET-1 on proliferative transforming growth factor (TGFbeta (1)) expression, fibronectin and laminin release), differentiative [alpha-smooth muscle actin (alpha-SMA) expression] and inflammatory [monocyte chemo-attractant protein (MCP-1) and interleukin-6 (IL-6) expression] responses in skin fibroblasts of healthy subjects (C) and D, testing the relative role of ET (A) and ET (B) receptors in mediating these responses. |
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| 18989869 | Aguilar RP, Genta S, Oliveros L, Anzulovich A, Gimenez MS, Sanchez SS: deficiency injures liver parenchyma and alters the expression of hepatic extracellular matrix. J Appl Toxicol. 2009 Apr;29(3):214-22. Moreover, immunochemical methods revealed that deficiency led to an increased expression of hepatic fibronectin, laminin and collagen type IV. |
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| 17923018 | Xu GP, Li QQ, Cao XX, Chen Q, Zhao ZH, Diao ZQ, Xu ZD: [Effect of Smad7 on transforming growth factor-beta1-induced alveolar epithelial to mesenchymal transition]. Zhonghua Yi Xue Za Zhi. 2007 Jul 17;87(27):1918-23. The expression of the markers of the epithelial cells, including E-cadherin and cytokeratin-19 (CK19), and markers of mesenchymal cells, including fibronectin (FN), vimentin, and alpha-smooth muscle actin (alpha-SMA) were assayed using Western blotting and real-time PCR. |
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| 20353040 | Yuan JL, Zhang Y, Jiang ZH: [Effects of fuzheng huayu recipe in antagonizing rat's renal interstitial fibrosis]. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5549-57. Serum (Cr) and urea (BUN) content were tested with corresponding test kits; (Hyp) content in kidney was assayed with hydrolysis; renal histologic change was observed with HE, Masson and methenamine silver (PASM) staining; and collagen type I (Col I), as well as protein expressions of fibronectin (FN) and alpha-smooth muscle actin (alpha-SMA) was determined with Western blot. |
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| 18610632 | Liu X, Wu W, Chen H: [Effects of CTGF gene silencing on the proliferation and myofibroblast differentiation of human lung fibroblasts]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Apr;25(2):407-12. Moreover, the deposition of extracellular matrix (ECM) proteins (such as collagen type I and fibronectin) in CTGF-siRNA/MRC-5 cells was also declined. |
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| 18154518 | Kim J, Kang HM, Kim H, Kim MR, Kwon HC, Gye MC, Kang SG, Yang HS, You J: Ex vivo characteristics of human amniotic membrane-derived stem cells. . Cloning Stem Cells. 2007 Winter;9(4):581-94. Immunophenotype analysis of HAM cells revealed the presence of antigens for SSEA-3, SSEA-4, collagen type-I, -II, -III, -IV, -XII, fibronectin, alpha-SMA, vimentin, desmin, cytokeratin18 (CK18), HCAM-1, fibroblast surface protein, and human leukocyte antigen (HLA) ABC. |
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| 17963106 | Dogru M, Kato N, Matsumoto Y, Tanaka Y, Akabane N, Shimmura S, Tsubota K, Shimazaki J: Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Toxicology. 2007 Sep 5;238(2-3):200-10. Epub 2007 Jun 17. The corneal buttons were processed for histologic examination with hematoxylin and eosin staining and underwent immunohistochemistry stainings for collagen types I, III, IV, V, VI, VIII, fibronectin, laminin, and decorin. |
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| 20058207 | Cai X, Lin Y, Friedrich CC, Neville C, Pomerantseva I, Sundback CA, Zhang Z, Vacanti JP, Hauschka PV, Grottkau BE: Bone marrow derived pluripotent cells are pericytes which contribute to vascularization. Stem Cell Rev. 2009 Dec;5(4):437-45. A 3-D culture model was then applied to test their vascularization by loading alpha-SMA-GFP positive cells and endothelial cells on collagen-fibronectin gel. |
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| 19101551 | Ono A, Utsugi M, Masubuchi K, Ishizuka T, Kawata T, Shimizu Y, Hisada T, Hamuro J, Mori M, Dobashi K: redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation. FEBS Lett. 2009 Jan 22;583(2):357-62. Epub 2008 Dec 25. In human lung fibroblasts or bronchial smooth muscle cells, we demonstrated that an increase in the intracellular level suppressed TGF-beta1-induced phosphorylation of Smad3, while inhibiting TGF-beta1-induced expressions of CTGF, collagen type1, fibronectin and transformation into myofibroblasts, which are characterized by the expression of alpha-smooth muscle actin. |
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