Protein Information

Name interleukin 4
Synonyms B cell differentiation factor gamma; B cell growth factor; B cell stimulatory factor 1; BCDF gamma; BCDFg; BCDFgamma; BCGF; BSF 1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19996325 Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y: Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts. Gut. 2010 Apr;59(4):531-41. Epub 2009 Dec 8.


ST2L mRNA was weakly detected in unstimulated cells, and IL4 and interferon gamma (IFNgamma) strongly enhanced ST2L expression via STAT6 and STAT1 signalling, respectively.
2(0,0,0,2) Details
17997848 Armah HB, Wilson NO, Sarfo BY, Powell MD, Bond VC, Anderson W, Adjei AA, Gyasi RK, Tettey Y, Wiredu EK, Tongren JE, Udhayakumar V, Stiles JK: Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. Malar J. 2007 Nov 12;6:147.


Serum and CSF levels of 36 different biomarkers (IL-1beta, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, Eotaxin, FGF basic protein, CRP, G-CSF, GM-CSF, IFN-gamma, TNF-alpha, IP-10, MCP-1 (MCAF), MIP-1alpha, MIP-1beta, RANTES, SDF-1alpha, CXCL11 (I-TAC), Fas-ligand [Fas-L], soluble Fas [sFas], sTNF-R1 (p55), sTNF-R2 (p75), MMP-9, TGF-beta1, PDGF bb and VEGF) were measured and the results compared between the 3 groups.
1(0,0,0,1) Details
19410625 Tao FF, Yang YF, Wang H, Sun XJ, Luo J, Zhu X, Liu F, Wang Y, Su C, Wu HW, Zhang ZS: Th1-type epitopes-based cocktail PDDV attenuates hepatic fibrosis in C57BL/6 mice with chronic Schistosoma japonicum infection. Vaccine. 2009 Jun 24;27(31):4110-7. Epub 2009 May 15.


The histopathological staging and collagen assessment for fibrosis showed that the cocktail PDDV presented an obvious down-regulation effect on hepatic fibrosis caused by chronic S. japonicum infection (P <0.05), and IFN-gamma, IL-4 and IL-13 mRNAs in liver detected by RT-PCR also showed that the cocktail PDDV represented the ability to up-regulate Th1-type responses, which paralleled with a decrease expression of alpha-SMA (P <0.05) and the up-regulated MMP9/TIMP1 balance (P <0.05) when compared to the control groups.
1(0,0,0,1) Details
17803855 Chen XH, Zhong NS, Zhang WD, Cao ZZ, He MZ, Luo Q, Ren XL, Li SY, L L: [Budesonide attenuates airway remodeling and modules the expression of Janus protein tyrosine kinase 1, and signal transducers and activators of transcription 6 in asthma: an experiment with mice]. Zhonghua Yi Xue Za Zhi. 2007 Jun 19;87(23):1627-32.


Then bronchoalveolar lavage fluid (BALF) was obtained and ELISA was used to measure the contents of interleukin (IL)-4 and IL-13.
4(0,0,0,4) Details
19143945 Efrati S, Berman S, Chachashvili A, Cohen N, Siman-Tov Y, Averbukh Z, Weissgarten J: Rosiglitazone treatment attenuates renal tissue inflammation generated by urinary tract obstruction. Nephrology. 2009 Apr;14(2):189-97.


The animals were killed and their kidneys allocated following 1 h, 24 h or 2 weeks, for pathological examination or for intrarenal transforming growth factor (TGF)-beta, interleukin (IL)-4, IL-6, IL-10 and nitric oxide (NO) assessment by specific enzyme-linked immunosorbent assays.
2(0,0,0,2) Details
18641694 Du Q, Chen Z, Zhou LF, Zhang Q, Huang M, Yin KS: Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma. Can J Physiol Pharmacol. 2008 Jul;86(7):449-57.


Astragaloside IV treatment resulted in significant reduction of eosinophilic airway inflammation, airway hyperresponsiveness, interleukin (IL)-4 and IL-13 levels in bronchoalveolar lavage fluid, and total immunoglobulin E levels in serum.
1(0,0,0,1) Details
17572012 Santak G, Santak M, Forcic D: Native human IFN-alpha is a more potent suppressor of HDF response to profibrotic stimuli than recombinant human IFN-alpha. J Interferon Cytokine Res. 2007 Jun;27(6):481-90.


Both, nHuIFN-alpha and rHuIFN-alpha antagonize the effect of exogenous transforming growth factor-beta (TGF-beta) and interleukin-4 (IL-4) as measured by the alpha-smooth muscle actin (alpha -SMA) and procollagen type I mRNA level, but the effect of nHuIFN-alpha is more pronounced.
1(0,0,0,1) Details