Protein Information

Name interferon gamma
Synonyms IFG; IFI; IFN gamma; IFNG; IFNgamma; Immune interferon; Interferon gamma; Interferon gamma precursor…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19797174 Bujak M, Dobaczewski M, Gonzalez-Quesada C, Xia Y, Leucker T, Zymek P, Veeranna V, Tager AM, Luster AD, Frangogiannis NG: Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Zhonghua Shao Shang Za Zhi. 2009 Dec;25(6):454-9.


RATIONALE: Interferon-gamma-inducible protein (IP)-10/CXCL10, an angiostatic and antifibrotic chemokine with an important role in T-cell trafficking, is markedly induced in myocardial infarcts, and may regulate the reparative response.
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18705328 Ha MH, Wei L, Rao HY, Liu F, Wang XY, Feng B, Fei R, Chen HS, Cong X: Effect of interferon-gamma on hepatic stellate cells stimulated by acetaldehyde. 943.

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19065677 Elinav E, Ali M, Bruck R, Brazowski E, Phillips A, Shapira Y, Katz M, Solomon G, Halpern Z, Gertler A: Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function. Hepatology. 2009 Jan;49(1):278-86.


In the chronic TAA fibrosis model, leptin administration was associated with significantly enhanced liver disease and a 100% 5-week to 8-week mortality rate, while administration or coadministration of MLA markedly improved survival, attenuated liver fibrosis, and reduced interferon gamma (IFN-gamma) levels.
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20193171 Liu JQ, Hu DH, Zhang ZF, Guan H, She T, Zhang J, Bai XZ: [Effects of interferon-gamma on the transforming growth factor beta/Smad pathway in keloid-derived fibroblasts]. Hepatogastroenterology. 2008 May-Jun;55(84):1059-65.

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19253820 Li Q, Fan JM, Pu L, Li Z, Qin W, Su BH: [Effects of interferon-gamma on tubular epithelial-myofibroblast transdifferentiation in vitro]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):895-9

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19996325 Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y: Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts. Circ Res. 2009 Nov 6;105(10):973-83. Epub 2009 Sep 24.


ST2L mRNA was weakly detected in unstimulated cells, and IL4 and interferon gamma (IFNgamma) strongly enhanced ST2L expression via STAT6 and STAT1 signalling, respectively.
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19961309 Miller J, Eisele G, Tabatabai G, Aulwurm S, von Kurthy G, Stitz L, Roth P, Weller M: Soluble CD70: a novel immunotherapeutic agent for experimental glioblastoma. J Neurosurg. 2009 Dec 4.


They assessed the immunogenicity of the transfected cells in cocultures with immune effector cells by the determination of immune cell proliferation and the release of interferon-gamma.
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