| Name | bFGF |
|---|---|
| Synonyms | BFGF; BHBGF 2; BHBGF2; Basic fibroblast growth factor; FGF; FGF2; FGFB; Fibroblast growth factor 2… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19008723 | Suzuki T, Akasaka Y, Namiki A, Ito K, Ishikawa Y, Yamazaki J, Ishii T: Basic fibroblast growth factor inhibits ventricular remodeling in Dahl salt-sensitive hypertensive rats. J Hypertens. 2008 Dec;26(12):2436-44. |
10(0,0,0,10) | Details |
| 19614927 | Ishiguro S, Akasaka Y, Kiguchi H, Suzuki T, Imaizumi R, Ishikawa Y, Ito K, Ishii T: Basic fibroblast growth factor induces down-regulation of alpha-smooth muscle actin and reduction of myofibroblast areas in open skin wounds. Wound Repair Regen. 2009 Jul-Aug;17(4):617-25. |
6(0,0,0,6) | Details |
| 20128380 | Lin YZ, Cai JM, Chen L, Yang ZP, Zhang JC, Wu W, Ke D, Xu CX: [Relationship between atrial fibroblast proliferation/fibrosis and atrial fibrillation in patients with rheumatic heart disease]. Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Sep;37(9):813-7. OBJECTIVE: To investigate the association between gene expressions of basic fibroblast growth factor (bFGF), smooth muscle alpha-actin (alpha-SMA) and proliferating cell nuclear antigen (PCNA) and atrial fibrosis in patients with atrial fibrillation (AF). |
5(0,0,0,5) | Details |
| 17707916 | Boero S, Sabatini F, Silvestri M, Petecchia L, Nachira A, Pezzolo A, Scarso L, Rossi GA: Modulation of human lung fibroblast functions by ciclesonide: evidence for its conversion into the active metabolite desisobutyryl-ciclesonide. Immunol Lett. 2007 Sep 15;112(1):39-46. Epub 2007 Aug 1. METHODS: Ciclesonide (0.09-9.0 microM) was added to a human adult lung fibroblast cell line (CCL-202), seeded in medium in the presence of the following cytokines and growth factors: (a) basic fibroblast growth factor (bFGF) for cell proliferation, measured by tritiated ([3H] TdR) incorporation; (b) tumour necrosis factor (TNF)-alpha, to stimulate intercellular adhesion molecule (ICAM)-1 expression and monocyte chemoattractant protein-1 (MCP-1) and eotaxin release, evaluated by flow cytometry and ELISA, respectively; (c) transforming growth factor (TGF)-beta1, for induction of alpha smooth muscle actin (alpha-SMA) protein expression and modification of the organization of alpha-SMA stress fibres, evaluated by Western blot analysis and fluorescence microscopy. |
2(0,0,0,2) | Details |
| 18266877 | Borowski A, Kuepper M, Horn U, Knupfer U, Zissel G, Hohne K, Luttmann W, Krause S, Virchow JC Jr, Friedrich K: Interleukin-13 acts as an apoptotic effector on lung epithelial cells and induces pro-fibrotic gene expression in lung fibroblasts. Clin Exp Allergy. 2008 Apr;38(4):619-28. Epub 2008 Feb 11. The ability of IL-13 to increase the expression of pro-fibrotic genes and to exert influence on the expression of its own receptor was investigated by real-time quantitative PCR measurement of mRNAs encoding collagen I, collagen III, basic fibroblast growth factor (bFGF), alpha-smooth muscle actin (alpha-SMA) and the IL-13 receptor alpha1 (IL-13Ralpha1) chain in human primary lung fibroblasts. |
1(0,0,0,1) | Details |
| 19339244 | Chen PY, Simons M, Friesel R: FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression. J Biol Chem. 2009 Jun 5;284(23):15980-92. Epub 2009 Apr 1. Platelet-derived growth factor (PDGF)-BB is a potent inducer of the VSMC synthetic phenotype; however, much less is known about the role of fibroblast growth factor-2 (FGF2) in this process. Here, we show using signal transduction mutants of FGF receptor 1 (FGFR1) expressed in rat VSMC that the adaptor protein FRS2 is essential for FGFR1-mediated phenotypic modulation and down-regulation of VSMC smooth muscle alpha-actin (SMA) gene expression. |
1(0,0,0,1) | Details |
| 20163211 | Cheng MT, Liu CL, Chen TH, Lee OK: Comparison of Potentials between Stem Cells Isolated from Human Anterior Cruciate Ligament and Bone Marrow for Ligament Tissue Engineering. Tissue Eng Part A. 2010 Feb 17. The purpose of this study was to evaluate the differences in proliferation, differentiation, and extracellular matrix (ECM) formation abilities between bone marrow stem cells (BMSCs) and ACL-derived stem cells (LSCs) from the same donors when cultured with different growth factors including basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and transforming growth factor-beta 1 (TGF-beta1). |
3(0,0,0,3) | Details |
| 19011011 | Yadav UC, Ighani-Hosseinabad F, van Kuijk FJ, Srivastava SK, Ramana KV: Prevention of posterior capsular opacification through aldose reductase inhibition. Invest Ophthalmol Vis Sci. 2009 Feb;50(2):752-9. Epub 2008 Nov 14. The effect of AR inhibition on basic fibroblast growth factor (BFGF)-induced mitogenic signaling in cultured human lens epithelial cells (HLECs) was examined. |
3(0,0,0,3) | Details |
| 19329552 | Schuliga MJ, See I, Ong SC, Soon L, Camoretti-Mercado B, Harris T, Stewart AG: Fibrillar collagen clamps lung mesenchymal cells in a nonproliferative and noncontractile phenotype. Am J Respir Cell Mol Biol. 2009 Dec;41(6):731-41. Epub 2009 Mar 27. DNA profiles indicated that fCollagen is antiproliferative, rather than proapoptotic. fCollagen suppressed basic fibroblast growth factor-stimulated increases in the levels of cyclin E and CDK2 mRNA. fCollagen also suppressed transforming growth factor-beta (100 pM)-stimulated increases in the mRNA and protein levels of alpha-smooth muscle actin (alpha-SMA), a marker of the myofibroblast phenotype. |
1(0,0,0,1) | Details |
| 19395679 | Hu B, Wu YM, Wu Z, Phan SH: Nkx2.5/Csx represses myofibroblast differentiation. Am J Respir Cell Mol Biol. 2010 Feb;42(2):218-26. Epub 2009 Apr 24. Analysis of nkx2.5 gene expression indicates that it was significantly induced by basic fibroblast growth factor treatment of isolated lung fibroblasts in vitro. To determine their functional importance, site-directed mutagenesis directed at these elements individually and in combination indicated that mutation of NKE1 and -3 significantly enhanced alpha-SMA gene promoter activity, whereas mutation of NKE2 did not have a significant effect. |
1(0,0,0,1) | Details |
| 19617559 | Bruns AF, van Bergeijk J, Lorbeer C, Nolle A, Jungnickel J, Grothe C, Claus P: Fibroblast growth factor-2 regulates the stability of nuclear bodies. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12747-52. Epub 2009 Jul 17. |
1(0,0,0,1) | Details |
| 18713669 | Layman H, Sacasa M, Murphy AE, Murphy AM, Pham SM, Andreopoulos FM: Co-delivery of FGF-2 and G-CSF from gelatin-based hydrogels as angiogenic therapy in a murine critical limb ischemic model. Acta Biomater. 2009 Jan;5(1):230-9. Epub 2008 Aug 3. Herein, we report on the immobilization and controlled release of human recombinant basic fibroblast growth factor (FGF-2) and human recombinant granulocyte colony-stimulating factor (G-CSF) from ionic, gelatin-based hydrogel scaffolds to re-establish perfusion and induce capillary outgrowth in a murine hindlimb ischemic model. |
1(0,0,0,1) | Details |
| 19641531 | Cucchiarini M, Schetting S, Terwilliger EF, Kohn D, Madry H: rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions. Gene Ther. 2009 Nov;16(11):1363-72. Epub 2009 Jul 30. We tested the hypothesis that overexpression of fibroblast growth factor 2 (FGF-2) through recombinant adeno-associated virus (rAAV) vectors leads to detectable metabolic changes in human meniscal fibrochondrocytes and in human meniscal defects. rAAV-mediated gene transfer was investigated for its ability to promote FGF-2 secretion in human meniscal fibrochondrocytes in vitro, in intact human meniscal explants in situ, and in experimentally created human meniscal lesions. |
1(0,0,0,1) | Details |
| 19283727 | Kurane A, Vyavahare N: In vivo vascular tissue engineering: influence of cytokine and implant location on tissue specific cellular recruitment. J Tissue Eng Regen Med. 2009 Jun;3(4):280-9. In this study, elastin tubes with agarose gel containing either stromal-derived factor-1 alpha [SDF; for homing of endothelial cells (ECs)] or basic fibroblast growth factor (bFGF; for homing of myofibroblasts) were implanted into adipose tissue, as it is a known source of stem/progenitor cells. |
1(0,0,0,1) | Details |
| 17576007 | Ilkhanizadeh S, Teixeira AI, Hermanson O: Inkjet printing of macromolecules on hydrogels to steer neural stem cell differentiation. Biomaterials. 2007 Sep;28(27):3936-43. Epub 2007 Jun 18. NSCs cultured on areas printed with fibroblast growth factor-2 (FGF2) remained undifferentiated, consistent with the effects of FGF2 when administered in solution. |
1(0,0,0,1) | Details |
| 18087244 | Banh A, Deschamps PA, Vijayan MM, Sivak JG, West-Mays JA: The role of Hsp70 and Hsp90 in TGF-beta-induced epithelial-to-mesenchymal transition in rat lens epithelial explants. Mol Vis. 2007 Nov 29;13:2248-62. The explants were divided into eight treatment groups: control (culture medium), fibroblast growth factor-2 (FGF-2), TGF-beta2, and TGF-beta2+FGF-2 under normal culture conditions and heat shocked conditions. |
1(0,0,0,1) | Details |
| 17937857 | Yang XS, Luo XM, Xiao B, Li XZ: [An experimental research on differentiation of mesenchymal stem cells derived from children with spinal muscular atrophy into neuron-like cells]. Zhongguo Dang Dai Er Ke Za Zhi. 2007 Oct;9(5):453-6. MSCs were isolated and purified from SMA patients and controls, and induced into NLCs by bFGF and baicalin. |
1(0,0,0,1) | Details |
| 18361994 | De Keyzer K, Leysen I, Timmermans JP, Tassignon MJ: Lens epithelial cells in an in vitro capsular bag model: lens-in-the-bag versus bag-in-the-lens technique. J Cataract Refract Surg. 2008 Apr;34(4):687-95. Each group was divided into 3 subgroups depending on the composition of the culture medium: calf serum only; calf serum enriched with basic fibroblast growth factor (b-FGF); calf serum enriched with transforming growth factor beta (TGF-beta (2)). |
1(0,0,0,1) | Details |