Protein Information

Name laminin (protein family or complex)
Synonyms Laminin; Laminins

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17846326 Sales VL, Engelmayr GC Jr, Johnson JA Jr, Gao J, Wang Y, Sacks MS, Mayer JE Jr: Protein precoating of elastomeric tissue-engineering scaffolds increased cellularity, enhanced extracellular matrix protein production, and differentially regulated the phenotypes of circulating endothelial progenitor cells. Circulation. 2007 Sep 11;116(11 Suppl):I55-63.


METHODS AND RESULTS: Elastomeric poly (glycerol sebacate) scaffolds were precoated with laminin, fibronectin, fibrin, collagen types I/III, or elastin.
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17846888 Jaskiewicz K, Rzepko R, Sledzinski Z: Fibrogenesis in fatty liver associated with obesity and diabetes mellitus type 2. Dig Dis Sci. 2008 Mar;53(3):785-8. Epub 2007 Sep 12.


Immunohistochemical stains included collagen IV, SMA and laminin.
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18400254 Qiu X, Montgomery E, Sun B: Inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma: a comparative study of clinicopathologic features and further observations on the immunohistochemical profile of myofibroblasts. Hum Pathol. 2008 Jun;39(6):846-56. Epub 2008 Apr 8.


The primary antibodies used in this study were specific for the ultrastructural subcellular components: (1) *-smooth muscle actin (*-SMA), muscle-specific actin (MSA), calponin, and h-caldesmon for myofilaments; (2) fibronectin for fibronexus; (3) laminin for basal lamina; (4) desmin and cytokeratin for intermediate filaments.
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19626665 Huh MI, Kim YH, Park JH, Bae SW, Kim MH, Chang Y, Kim SJ, Lee SR, Lee YS, Jin EJ, Sonn JK, Kang SS, Jung JC: Distribution of TGF-beta isoforms and signaling intermediates in corneal fibrotic wound repair. J Cell Biochem. 2009 Oct 1;108(2):476-88.


In normal cornea, laminin was mainly detected in both epithelial basement membrane (BM) and Descemet's membrane (DM).
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18989869 Aguilar RP, Genta S, Oliveros L, Anzulovich A, Gimenez MS, Sanchez SS: Vitamin A deficiency injures liver parenchyma and alters the expression of hepatic extracellular matrix. J Appl Toxicol. 2009 Apr;29(3):214-22.


Moreover, immunochemical methods revealed that vitamin A deficiency led to an increased expression of hepatic fibronectin, laminin and collagen type IV.
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18471414 Huan HD, Zhang JH, Zheng SR, Meng WW, Zhang JL: [Dilingdan Decoction prevents renal interstitial fibrosis in a rat model of unilateral ureteral obstruction]. Zhong Xi Yi Jie He Xue Bao. 2008 May;6(5):493-7.


The expressions of transforming growth factor-beta1 (TGF-beta1), alpha-smooth muscle actin (alpha-SMA), fibronectin (FN) and laminin (LN) were detected by immunohistochemical method and colored-multimedia pathological image analysis system.
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20025519 Yu Y, Lv L, Qian X, Chen N, Yao A, Pu LY, Zhang F, Li XC, Kong LB, Sun BC, Wang X: Anti-fibrotic Effect of Hepatocyte Growth Factor-expressing Mesenchymal Stem Cells in Small-for-size Liver Transplant Rats. Stem Cells Dev. 2009 Dec 21.


Fibrosis indexes, including laminin (LN), hyaluronic acid (HA) levels in serum and hydroxyproline (Hyp) content in the liver grsfts, the expression of transforming growth factor-beta1 (TGF-beta1), rat HGF (rHGF), alpha-smooth muscle actin (alpha-SMA) in hepatic stellate cells (HSCs), alanine aminotransferase (ALT), total bilirubin (BIL) and albumin (ALB) levels in serum, in rats in different treatment groups were assessed at different time points.
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19217158 Zhang H, Tasnim F, Ying JY, Zink D: The impact of extracellular matrix coatings on the performance of human renal cells applied in bioartificial kidneys. Biomaterials. 2009 May;30(15):2899-911. Epub 2009 Feb 12.


The best results were obtained with ECMs consisting of the basal lamina components, laminin or collagen IV, and differentiated epithelia could be maintained up to three weeks on these ECMs.
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19451194 Mehasseb MK, Bell SC, Habiba MA: The effects of tamoxifen and estradiol on myometrial differentiation and organization during early uterine development in the CD1 mouse. Reproduction. 2009 Aug;138(2):341-50. Epub 2009 May 18.


We examined the sections histologically, using image analysis and immunohistochemistry for alpha-smooth muscle actin (alpha-SMA), desmin, vimentin, laminin, fibronectin, and estrogen receptor-alpha.
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19146948 Maolood N, Meister B: Protein components of the blood-brain barrier (BBB) in the brainstem area postrema-nucleus tractus solitarius region. J Chem Neuroanat. 2009 May;37(3):182-95. Epub 2008 Dec 25.


To clarify the cellular localization of protein components of the BBB in the brainstem AP-NTS region, we used antisera to--(1) Tight junctions: claudin-5 and zona occludens-1 (ZO-1). (2) Endothelial cells: (a) all endothelial cells--rat endothelial cell antigen-1 (RECA-1) and (b) endothelial cells at BBB--endothelial barrier antigen (EBA), glucose transporter 1 (GLUT1) and transferrin receptor (TfR). (3) Basal lamina--laminin. (4) Vascular smooth muscle cells--smooth muscle actin (SMA). (5) Pericytes--chondroitin sulfate proteoglycan (NG2). (6) Glial cells: (a) astrocytes--glial fibrillary acidic protein (GFAP), (b) tanycytes--dopamine- and cAMP-regulated phosphoprotein of 32 kDA (DARPP-32), and (c) microglia--CD11b.
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19567170 Deng ZY, Li J, Jin Y, Chen XL, Lu XW: Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis. Chin Med J. 2009 Jun 20;122(12):1449-54.


We obesrved changes in deposition of collagen, hyaluronic acid (HA), laminin (LN), collagen type IV (CIV), procollagen III (PCIII) and hydroxyproline (Hyp), a-smooth muscle actin (alpha-SMA) and phosphor-p38 (pp38).
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18990339 Wang XB, Liu P, Tang ZP, Li FH, Liu CH, Hu YY, Xu LM: [Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamine-induced liver cirrhosis: a study on its histological basis]. Zhong Xi Yi Jie He Xue Bao. 2008 Nov;6(11):1136-44.


The expressions of CD44, von Willebrand factor (vWF), laminin (LM), alpha-smooth muscle actin (alpha-SMA), type I collagen (Col I) and type IV collagen (Col IV) proteins in the hepatic sinusoida l walls were examined by immunohistochemistry.
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18522880 Zheng JF, Liang LJ: Intra-portal transplantation of bone marrow stromal cells ameliorates liver fibrosis in mice. Hepatobiliary Pancreat Dis Int. 2008 Jun;7(3):264-70.


Mice were killed after 3 months, and ALT, AST, hyaluronic acid (HA), and laminin (LN) in serum and hydroxyproline (Hyp) in the liver were assessed.
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18602987 Norsted E, Gomuc B, Meister B: Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus. J Chem Neuroanat. 2008 Oct;36(2):107-21. Epub 2008 Jun 18.


In order to clarify the nature of the BBB in the median eminence-arcuate nucleus complex, we have used immunohistochemistry and antisera to protein components of the BBB-(1) tight junctions, claudin-5 and zona occludens-1 (ZO-1); (2) endothelial cells: (a) all endothelial cells: rat endothelial cell antigen-1 (RECA-1), (b) endothelial cells at BBB: endothelial barrier antigen (EBA), glucose transporter 1 (GLUT1) and transferrin receptor (TfR), and (c) endothelial cells at CVOs: dysferlin; (3) basal lamina: laminin; (4) vascular smooth muscle cells: smooth muscle actin (SMA); (5) pericytes: chondroitin sulfate proteoglycan (NG2); (6) glial cells: (a) astrocytes: glial fibrillary acidic protein (GFAP), (b) tanycytes: dopamine- and cAMP-regulated phosphoprotein of 32kDA (DARPP-32), (c) microglia: CD11b.
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18365870 Solini A, Santini E, Madec S, Cuccato S, Ferrannini E: Effects of endothelin-1 on fibroblasts from type 2 diabetic patients: Possible role in wound healing and tissue repair. Growth Factors. 2007 Dec;25(6):392-9.


We compared the effect of ET-1 on proliferative transforming growth factor (TGFbeta (1)) expression, fibronectin and laminin release), differentiative [alpha-smooth muscle actin (alpha-SMA) expression] and inflammatory [monocyte chemo-attractant protein (MCP-1) and interleukin-6 (IL-6) expression] responses in skin fibroblasts of healthy subjects (C) and D, testing the relative role of ET (A) and ET (B) receptors in mediating these responses.
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17963106 Dogru M, Kato N, Matsumoto Y, Tanaka Y, Akabane N, Shimmura S, Tsubota K, Shimazaki J: Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. Curr Eye Res. 2007 Oct;32(10):863-70.


The corneal buttons were processed for histologic examination with hematoxylin and eosin staining and underwent immunohistochemistry stainings for collagen types I, III, IV, V, VI, VIII, fibronectin, laminin, and decorin.
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19940066 Pattabiraman PP, Rao PV: Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 2010 Mar;298(3):C749-63. Epub 2009 Nov 25.


TM cells expressing RhoAV14 exhibited significant increases in fibronectin, tenascin C, laminin, alpha-smooth muscle actin (alpha-SMA) levels, and matrix assembly in association with increased actin stress fibers and myosin light-chain phosphorylation.
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19670705 Gajda M, Zagolski O, Jasztal A, Lis GJ, Adamek D, Litwin JA: Giant schwannoma of the cheek--a comprehensive histological and immunohistochemical description of a rare tumour. Pol J Pathol. 2009 Mar;60(1):52-6.


It showed positive immunostaining for S-100, PGP 9.5, NSE, collagen IV, laminin, merosin and vimentin.
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