Protein Information

Name sulfatase
Synonyms ARS; RGS 2; RGS2; RIEG 2; RIEG2; ARS; Arylsulfatase C; nitrocatechol sulfatase…

Compound Information

Name sulfuric acid
CAS sulfuric acid

Reference List

PubMed Abstract RScore(About this table)
12732552 Pogorevc M, Faber K: Purification and characterization of an inverting stereo- and enantioselective sec-alkylsulfatase from the gram-positive bacterium Rhodococcus ruber DSM 44541. Appl Environ Microbiol. 2003 May;69(5):2810-5.


In contrast to sulfatase RS1, enzyme RS2 proved to be reasonably stable and thus could be purified to homogeneity.
2(0,0,0,2) Details
16966419 Kamimura K, Koyama T, Habuchi H, Ueda R, Masu M, Kimata K, Nakato H: Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. J Cell Biol. 2006 Sep 11;174(6):773-8.


The restricted phenotypes of Hsst mutants are ascribed to this compensation because FGF signaling is strongly disrupted by Hs2st; Hs6st double mutation, or by overexpression of 6-O sulfatase, an extracellular enzyme which removes 6-O sulfate groups without increasing 2-O sulfation.
1(0,0,0,1) Details
16120820 Martinez AW, Recht NS, Hostetter TH, Meyer TW: Removal of P-cresol sulfate by hemodialysis. J Am Soc Nephrol. 2005 Nov;16(11):3430-6. Epub 2005 Aug 24.


Treatment with sulfatase resulted in recovery of this peak as p-cresol, confirming its identity.
1(0,0,0,1) Details
14570471 Burlingham BT, Pratt LM, Davidson ER, Shiner VJ Jr, Fong J, Widlanski TS: 34S isotope effect on sulfate ester hydrolysis: mechanistic implications. J Am Chem Soc. 2003 Oct 29;125(43):13036-7.


The isotope effect method we report should also prove useful for studying the mechanism of other sulfuryl group transfers, including sulfatase and sulfotransferase reactions, as well as sulfate hydrolyses under other conditions.
1(0,0,0,1) Details
16161167 Wallner SR, Bauer M, Wurdemann C, Wecker P, Glockner FO, Faber K: Highly enantioselective sec-alkyl sulfatase activity of the marine planctomycete Rhodopirellula baltica shows retention of configuration. Angew Chem Int Ed Engl. 2005 Oct 7;44(39):6381-4.

1(0,0,0,1) Details
19183967 Mueller M, Kolbrich-Spargo EA, Peters FT, Huestis MA, Ricaurte GA, Maurer HH: Hydrolysis of 3,4-methylenedioxymethamphetamine (MDMA) metabolite conjugates in human, squirrel monkey, and rat plasma. Anal Bioanal Chem. 2009 Mar;393(6-7):1607-17. Epub 2009 Jan 30.

Two prominent MDMA metabolites, 3,4-dihydroxymethamphetamine (HHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA), are conjugated with glucuronic or sulfuric acid, but reference standards are not available; therefore, quantification is only possible after conjugate cleavage.
Acidic hydrolysis should be used for analyzing free HHMA and HMMA in human or squirrel monkey plasma, while enzymatic hydrolysis with glucuronidase or sulfatase maximizes recovery of free HHMA and HMMA in rat plasma.
1(0,0,0,1) Details
15606122 Wallner SR, Nestl BM, Faber K: Highly enantioselective sec-alkyl sulfatase activity of Sulfolobus acidocaldarius DSM 639. Org Lett. 2004 Dec 23;6(26):5009-10.

1(0,0,0,1) Details
19568649 Nagatsuka T, Uzawa H, Nishida Y: Library assembly of mono-, di- and tri-O-sulfated beta-D-xylopyranosides; effect of O-sulfation on pyranose ring conformation. Chem Commun. 2009 Jul 21;(27):4109-11. Epub 2009 Jun 8.


With molluscan sulfatase-catalyzed de-O-sulfation reactions, a series of mono-, di- and tri-O-sulfated p-nitrophenyl beta-D-xylopyranosides were assembled and applied to a 1H NMR study to examine the effect of O-sulfate groups on the equilibration between pyranose 4C1 and 1C4 conformations.
1(0,0,0,1) Details