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Stine ER, Hsu CA, Hoover TD, Aposhian HV, Carter DE: N-(2,3-dimercaptopropyl) phthalamidic acid: protection, in vivo and in vitro, against arsenic intoxication. Toxicol Appl Pharmacol. 1984 Sep 15;75(2):329-36.
The effectiveness of DMPA in reducing the toxicity of NaAsO2 was further demonstrated by its reversal of the sodium arsenite inhibition of pyruvate dehydrogenase multienzyme complex (PDH) activity in vitro. |
81(1,1,1,1) |
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6327446 |
Aposhian HV, Carter DE, Hoover TD, Hsu CA, Maiorino RM, Stine E: DMSA, DMPS, and DMPA--as arsenic antidotes. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 2):S58-70.
The sodium arsenite inhibition of the pyruvate dehydrogenase (PDH) complex can be prevented and reversed in vitro or in vivo by DMPS, DMSA, DMPA, or BAL. |
1(0,0,0,1) |
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