Protein Information

Name pyruvate dehydrogenase (protein family or complex)
Synonyms Pyruvate dehydrogenase; Pyruvate dehydrogenases

Compound Information

Name DMPA
CAS

Reference List

PubMed Abstract RScore(About this table)
6474464 Stine ER, Hsu CA, Hoover TD, Aposhian HV, Carter DE: N-(2,3-dimercaptopropyl) phthalamidic acid: protection, in vivo and in vitro, against arsenic intoxication. Toxicol Appl Pharmacol. 1984 Sep 15;75(2):329-36.

The effectiveness of DMPA in reducing the toxicity of NaAsO2 was further demonstrated by its reversal of the sodium arsenite inhibition of pyruvate dehydrogenase multienzyme complex (PDH) activity in vitro.
81(1,1,1,1) Details
6327446 Aposhian HV, Carter DE, Hoover TD, Hsu CA, Maiorino RM, Stine E: DMSA, DMPS, and DMPA--as arsenic antidotes. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 2):S58-70.

The sodium arsenite inhibition of the pyruvate dehydrogenase (PDH) complex can be prevented and reversed in vitro or in vivo by DMPS, DMSA, DMPA, or BAL.
1(0,0,0,1) Details