| Name | CYP19 |
|---|---|
| Synonyms | ARO; Microsomal monooxygenase; Flavoprotein linked monooxygenase; ARO 1; ARO1; Aromatase; Aromatase cytochrome P450; CPV 1… |
| Name | atrazine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15901915 | Hecker M, Park JW, Murphy MB, Jones PD, Solomon KR, Van Der Kraak G, Carr JA, Smith EE, du Preez L, Kendall RJ, Giesy JP: Effects of atrazine on CYP19 gene expression and aromatase activity in testes and on plasma sex steroid concentrations of male African clawed frogs (Xenopus laevis). Toxicol Sci. 2005 Aug;86(2):273-80. Epub 2005 May 18. |
12(0,0,2,2) | Details |
| 10746939 | Sanderson JT, Seinen W, Giesy JP, van den Berg M: 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?. Toxicol Sci. 2000 Mar;54(1):121-7. In this report we demonstrated that the commonly used 2-chloro-s-triazine herbicides atrazine, simazine, and propazine dose-dependently (0-30 microM) induced aromatase (CYP19) activity to an apparent maximum of about 2.5-fold in H295R cells. |
9(0,0,1,4) | Details |
| 12127262 | Sanderson JT, Boerma J, Lansbergen GW, van den Berg M: Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol. 2002 Jul 1;182(1):44-54. Vinclozolin, as was shown previously for atrazine, induced aromatase activity and CYP19 mRNA levels about 2.5- and 1.5-fold, respectively. |
7(0,0,1,2) | Details |
| 15234167 | Londono DK, Siegfried BD, Lydy MJ: Atrazine induction of a family 4 cytochrome P450 gene in Chironomus tentans (Diptera: Chironomidae). Chemosphere. 2004 Aug;56(7):701-6. Cytochrome P450-dependent microsomal monooxygenase (P450) activity was measured in control and atrazine-exposed third instar midge larvae, Chironomus tentans. |
6(0,0,1,1) | Details |
| 15210295 | Kazeto Y, Place AR, Trant JM: Effects of endocrine disrupting chemicals on the expression of CYP19 genes in zebrafish (Danio rerio) juveniles. Aquat Toxicol. 2004 Jul 30;69(1):25-34. The pharmaceutical, clofibrate, and the pesticide, atrazine, did not influence the expression of either CYP19 gene. |
5(0,0,0,5) | Details |
| 11675267 | Sanderson JT, Letcher RJ, Heneweer M, Giesy JP, van den Berg M: Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ Health Perspect. 2001 Oct;109(10):1027-31. We determined effects on human aromatase (CYP19), the enzyme that converts androgens to estrogens, in H295R (adrenocortical carcinoma), JEG-3 (placental choriocarcinoma), and MCF-7 (breast cancer) cells; we determined effects on estrogen receptor-mediated induction of vitellogenin in primary hepatocyte cultures of adult male carp (Cyprinus carpio). In addition to atrazine, simazine, and propazine, two metabolites--atrazine-desethyl and atrazine-desisopropyl--induced aromatase activity in H295R cells concentration-dependently (0.3-30 microM) and with potencies similar to those of the parent triazines. |
2(0,0,0,2) | Details |
| 18461179 | Suzawa M, Ingraham HA: The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells. PLoS One. 2008 May 7;3(5):e2117. Remarkably, in mammalian cells ATR functions in a cell-specific manner to upregulate SF-1 targets and other genes critical for steroid synthesis and reproduction, including Cyp19A1, StAR, Cyp11A1, hCG, FSTL3, LHss, INHalpha, alphaGSU, and 11ss-HSD2. |
1(0,0,0,1) | Details |
| 16996190 | Laville N, Balaguer P, Brion F, Hinfray N, Casellas C, Porcher JM, Ait-Aissa S: Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108. Epub 2006 Aug 24. Nine pesticides induced aromatase activity: aldrin, chlordane, cypermethrin, parathion-methyl, endosulfan, methoxychlor, oxadiazon, metolachlor and atrazine after 24 h of exposure, while tributyltin induced aromatase activity at 1 nM and 3 nM after both 2 h and 24 h of exposure, respectively. To further investigate the mechanisms of aromatase induction we measured CYP19 mRNA expression and showed that methoxychlor, aldrin, chlordane and tributyltin induced the transcription of the cyp19 gene. |
1(0,0,0,1) | Details |
| 18395276 | Oka T, Tooi O, Mitsui N, Miyahara M, Ohnishi Y, Takase M, Kashiwagi A, Shinkai T, Santo N, Iguchi T: Effect of atrazine on metamorphosis and sexual differentiation in Xenopus laevis. Aquat Toxicol. 2008 May 30;87(4):215-26. Epub 2008 Feb 23. Metamorphosis, gonadal morphology and histology, CYP19 (P450 aromatase) mRNA induction, and hepatic vitellogenin (VTG) induction were investigated. |
1(0,0,0,1) | Details |
| 15655806 | Gammon DW, Aldous CN, Carr WC Jr, Sanborn JR, Pfeifer KF: A risk assessment of atrazine use in California: human health and ecological aspects. Pest Manag Sci. 2005 Apr;61(4):331-55. The mechanism for tumor development may include one or more of the following: the induction of aromatase (CYP19) and/or other P450 oxygenases, an antagonist action at the feedback receptor in the hypothalamus, an agonist action at the mammary gland estrogen receptor or an effect on adrenergic neurons in the hypothalamic-pituitary pathway. |
1(0,0,0,1) | Details |
| 15178053 | Keller JM, McClellan-Green P: Effects of organochlorine compounds on cytochrome P450 aromatase activity in an immortal sea turtle cell line. Mar Environ Res. 2004 Aug-Dec;58(2-5):347-51. This study sought to develop an in vitro model for assessing EAC effects in sea turtles by examining their ability to alter cytochrome P450 aromatase (CYP19) activity. In addition, the GST-TS cells were exposed to 0.1-30 microM atrazine and 3-100 microM 4,4'-DDE. |
1(0,0,0,1) | Details |