Protein Information

Name methemoglobin
Synonyms Abnormal hemoglobin; G gamma globin; Gamma 2 globin; HBG 2; HBG2; Hb F Ggamma; Hemoglobin gamma G; Hemoglobin gamma 2 chain…

Compound Information

Name amitrole
CAS

Reference List

PubMed Abstract RScore(About this table)
1755337 Ohmori T, Takamoto K, Ogata M: The role of catalase in protecting erythrocytes against methemoglobin formation. Acta Med Okayama. 1991 Oct;45(5):321-4.

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1962528 Ohmori T, Ogata M: Methemoglobin formation by potassium ferrocyanide in the hemolysate of acatalasemic mice. Acta Med Okayama. 1991 Aug;45(4):209-15.

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8264727 Atamna H, Ginsburg H: Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum. Mol Biochem Parasitol. 1993 Oct;61(2):231-41.


The rate of conversion is further increased in the presence of the catalase inhibitor 3-amino-1,2,4-triazole (3-AT) and the extent of inhibition of the lysate catalase increases upon acidification, implying that H2O2 is thus produced by the spontaneous dismutation of superoxide radicals generated during methemoglobin formation.
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16274876 Johnson RM, Goyette G Jr, Ravindranath Y, Ho YS: Hemoglobin autoxidation and regulation of endogenous H2O2 levels in erythrocytes. Free Radic Biol Med. 2005 Dec 1;39(11):1407-17. Epub 2005 Aug 24.


Methemoglobin and the rate of catalase inactivation by 3-amino-2,4,5-triazole (3-AT) were determined.
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215336 Miura T, Ogiso T: Effect of 3-amino-1,2,4-triazole on catalase and formation of methemoglobin from oxyhemoglobin in erythrocyte by superoxide radicals. Chem Pharm Bull. 1978 Nov;26(11):3540-5.

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7682576 Scott MD, van den Berg JJ, Repka T, Rouyer-Fessard P, Hebbel RP, Beuzard Y, Lubin BH: Effect of excess alpha-hemoglobin chains on cellular and membrane oxidation in model beta-thalassemic erythrocytes. J Clin Invest. 1993 Apr;91(4):1706-12.


These "model" beta-thalassemic cells generated significantly (P < 0.001) greater amounts of methemoglobin and intracellular hydrogen peroxide than did control cells.
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