Protein Information

Name lactoperoxidase
Synonyms Airway lactoperoxidase; LPO; Lactoperoxidase; Lactoperoxidase precursor; SAPX; SPO; Salivary peroxidase; Lactoperoxidases…

Compound Information

Name amitrole
CAS

Reference List

PubMed Abstract RScore(About this table)
812211 Jellinck PH, Smith G, Cleveland S: Metabolism of (4-14C) estradiol by 7,12-dimethylbenz (a) anthracene-induced mammary tumor peroxidase. Steroids. 1975 Sep;26(3):329-37.


The properties of the enzyme found in the tumors were similar to those of lactoperoxidase.
1(0,0,0,1) Details
2519707 Doerge DR, Niemczura WP: Suicide inactivation of lactoperoxidase by 3-amino-1,2,4-triazole. Chem Res Toxicol. 1989 Mar-Apr;2(2):100-3.

Amitrole (3-amino-1,2,4-triazole) meets the criteria for a suicide (mechanism-based) inhibitor of lactoperoxidase.
406(5,5,5,6) Details
3107850 Krauss RS, Eling TE: Macromolecular binding of the thyroid carcinogen 3-amino-1,2,4-triazole (amitrole) catalyzed by prostaglandin H synthase, lactoperoxidase and thyroid peroxidase. Carcinogenesis. 1987 May;8(5):659-64.
163(2,2,2,3) Details
1953728 Metodiewa D, Dunford HB: 3-Aminotriazole is a substrate for lactoperoxidase but not for catalase. . Biochem Biophys Res Commun. 1991 Oct 31;180(2):585-90.


Rapid scan spectrophotometry has been applied to investigate the reaction of 3-aminotriazole with mammalian heme enzymes, represented by lactoperoxidase and bovine liver catalase.
1(0,0,0,1) Details
3015901 Thomas EL, Fishman M: Oxidation of chloride and thiocyanate by isolated leukocytes. . J Biol Chem. 1986 Jul 25;261(21):9694-702.


OSCN- was produced when SCN- was 0.1 mM or higher and myeloperoxidase, eosinophil peroxidase, or lactoperoxidase was added.
1(0,0,0,1) Details