Protein Information

Name pyruvate dehydrogenase (protein family or complex)
Synonyms Pyruvate dehydrogenase; Pyruvate dehydrogenases

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
7013545 Cederbaum AI: The effect of cyanamide on acetaldehyde oxidation by isolated rat liver mitochondria and on the inhibition of pyruvate oxidation by acetaldehyde. Alcohol Clin Exp Res. 1981 Jan;5(1):38-44.

These results indicate that (a) cyanamide can be used as an effective in vitro inhibitor of acetaldehyde oxidation and (b) the unique sensitivity of pyruvate oxidation to acetaldehyde represents a direct effect of acetaldehyde on pyruvate dehydrogenase.
81(1,1,1,1) Details
2226767 Ostrovskii SIu, Gorenshtein BI, Dosta GA, Karaedova LM, Nefedov LI: [Free amino acids of the liver and the characteristics of the amino acid metabolism in the liver and brain after cyanamide administration to rats]. Farmakol Toksikol. 1990 Jul-Aug;53(4):63-5.

The activities of transaminases, glutamate dehydrogenase, pyruvate dehydrogenase remained unchanged.
1(0,0,0,1) Details