Protein Information

Name caspase 8
Synonyms Apoptotic cysteine protease; Apoptotic protease Mch 5; CAP 4; CAP4; CASP 8; CASP8; CASP8 protein; Caspase 8…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
17222828 Hristova M, Heuvelmans S, van der Vliet A: GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein. . FEBS Lett. 2007 Feb 6;581(3):361-7. Epub 2007 Jan 12.
88(1,1,2,3) Details
17320762 Tanel A, Averill-Bates DA: Activation of the death receptor pathway of apoptosis by the aldehyde acrolein. Free Radic Biol Med. 2007 Mar 15;42(6):798-810. Epub 2006 Dec 14.

Exposure of Chinese hamster ovary cells to acrolein caused translocation of adaptor protein Fas associated with death domain to the cytoplasmic membrane and caspase-8 activation.
63(0,2,2,3) Details
15964311 Wu SJ, Ng LT, Lin CC: Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway. Life Sci. 2005 Jul 8;77(8):938-51. Epub 2005 Mar 19.


Treatment with 1 microM Cin resulted in an activation of caspase-8 and cleavage of Bid to its truncated form in a time-dependent pattern.
1(0,0,0,1) Details
17035713 Benesic A, Schwerdt G, Freudinger R, Mildenberger S, Groezinger F, Wollny B, Kirchhoff A, Gekle M: Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. Kidney Blood Press Res. 2006;29(5):280-93. Epub 2006 Oct 11.


CAA but not acrolein inhibited the cysteine proteases caspase-3, caspase-8 and cathepsin B.
0(0,0,0,0) Details