| Name | heme oxygenase 1 |
|---|---|
| Synonyms | HMOX 1; HMOX1; HMOX1 protein; HO; HO 1; HO1; Heme oxygenase (Decycling) 1; Heme oxygenase (Decyclizing) 1… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16480751 | Wu CC, Hsieh CW, Lai PH, Lin JB, Liu YC, Wung BS: Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):244-52. Epub 2006 Feb 15. |
219(2,3,7,9) | Details |
| 18048804 | Zhang H, Forman HJ: Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2008 Apr;38(4):483-90. Epub 2007 Nov 29. Acrolein-mediated HO-1 induction was significantly attenuated by pan-protein kinase C (PKC) inhibitors RO318220, staurosporine, and PKC-delta selective inhibitor rottlerin and PKC-delta small interfering RNA. |
114(1,1,6,9) | Details |
| 19548348 | Thompson CA, Burcham PC: Genome-wide transcriptional responses to acrolein. . Chem Res Toxicol. 2008 Dec;21(12):2245-56. Although HMOX1 is a widely used marker of transcriptional responses to acrolein, this gene was the sole upregulated member of the Nrf2-driven family of antioxidant response genes. |
7(0,0,1,2) | Details |
| 18921984 | Thompson CA, Burcham PC: Genome-Wide Transcriptional Responses to Acrolein. . Chem Res Toxicol. 2008 Oct 16. Although HMOX1 is a widely used marker of transcriptional responses to acrolein, this gene was the sole upregulated member of the Nrf2-driven family of antioxidant response genes. |
7(0,0,1,2) | Details |
| 19651797 | Zhang H, Forman HJ: Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes. Toxicol Ind Health. 2009 May-Jun;25(4-5):269-78. Two electrophiles, (HNE) and acrolein, induced the expression of phase II genes (GCLC, GCLM, NQO1, NQO2, HO-1, and GSTM-1). |
6(0,0,1,1) | Details |
| 18304597 | Liao BC, Hsieh CW, Liu YC, Tzeng TT, Sun YW, Wung BS: inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2. Toxicol Appl Pharmacol. 2008 Jun 1;229(2):161-71. Epub 2008 Feb 5. Interestingly, exerts its anti-inflammatory effects by blocking the degradation of the inhibitory protein IkappaB-alpha, but only in short term pretreatments, whereas it does so via the induction of Nrf2-related genes, including heme-oxygenase-1 (HO-1), over long term pretreatments. |
4(0,0,0,4) | Details |
| 19608619 | MacLeod AK, McMahon M, Plummer SM, Higgins LG, Penning TM, Igarashi K, Hayes JD: Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis. 2009 Sep;30(9):1571-80. Epub 2009 Jul 16. Whole-genome microarray revealed that knockdown of KEAP1 resulted in 23 messenger RNAs (mRNAs) being up-regulated > or = 2.0-fold. mRNA for aldo-keto reductase (AKR) 1B10, AKR1C1, AKR1C2 and AKR1C3 were induced to the greatest extent, showing increases of between 12- and 16-fold, whereas mRNA for glutamate-cysteine ligase catalytic and modifier subunits, NAD (P) H:quinone oxidoreductase-1 and haem oxygenase-1 (HMOX1) were induced between 2.0- and 4.8-fold. Activation of NRF2, by KEAP1 knockdown, caused a 75% increase in the amount of in HaCaT cells and a 1.4- to 1.6-fold increase in their resistance to the electrophiles acrolein, chlorambucil and cumene hydroperoxide (CuOOH), as well as the redox-cycling agent |
2(0,0,0,2) | Details |
| 20153624 | Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Feb 12. Consequently, the expression and/or activity of the following Phase II enzymes increased: glutamate cysteine ligase, NAD (P) H:quinone oxidoreductase 1, heme-oxygenase 1, glutathione S-transferase and superoxide dismutase; total antioxidant capacity and also increased. |
1(0,0,0,1) | Details |
| 19000754 | Cabello CM, Bair WB 3rd, Lamore SD, Ley S, Bause AS, Azimian S, Wondrak GT: The cinnamon-derived Michael acceptor impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radic Biol Med. 2009 Jan 15;46(2):220-31. Epub 2008 Nov 1. Expression array analysis revealed that CA induced an oxidative stress response in A375 cells, up-regulating heme oxygenase 1, sulfiredoxin 1 homolog, thioredoxin reductase 1, and other genes, including the cell-cycle regulator and stress-responsive tumor suppressor gene cyclin-dependent kinase inhibitor 1A, a key mediator of G1-phase arrest. |
1(0,0,0,1) | Details |
| 18282682 | Thompson CA, Burcham PC: Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: influence of nucleophilic culture media constituents. Toxicol In Vitro. 2008 Jun;22(4):844-53. Epub 2008 Jan 15. Cell viability was assessed using the MTT assay, while heme oxygenase-1 (HO-1) and cytoplasmic cytochrome c were measured as respective markers of transcriptional response and apoptosis. |
1(0,0,0,1) | Details |
| 17178418 | King AA, Shaughnessy DT, Mure K, Leszczynska J, Ward WO, Umbach DM, Xu Z, Ducharme D, Taylor JA, Demarini DM, Klein CB: Antimutagenicity of and vanillin in human cells: Global gene expression and possible role of DNA damage and repair. Mutat Res. 2007 Mar 1;616(1-2):60-9. Epub 2006 Dec 18. RT-PCR results paralleled the Affymetrix results for four selected genes (HMOX1, DDIT4, GCLM, and CLK4). |
1(0,0,0,1) | Details |
| 20149621 | Zhu L, Liu Z, Feng Z, Hao J, Shen W, Li X, Sun L, Sharman E, Wang Y, Wertz K, Weber P, Shi X, Liu J: protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells. J Nutr Biochem. 2010 Feb 9. Studies in this laboratory have previously shown that the major antioxidant polyphenol in olives, protects ARPE-19 human retinal pigment epithelial cells from oxidative damage induced by acrolein, an environmental toxin and endogenous end product of lipid oxidation, that occurs at increased levels in age-related macular degeneration lesions. The activation of Nrf2 led to activation of phase II detoxifying enzymes, including gamma-glutamyl-cysteinyl-ligase, -quinone-oxidoreductase 1, heme-oxygenase-1, superoxide dismutase, peroxiredoxin and thioredoxin as well as other antioxidant enzymes, while the activation of PPARGC1alpha led to increased protein expression of mitochondrial transcription factor A, uncoupling protein 2 and mitochondrial complexes. |
1(0,0,0,1) | Details |
| 9266806 | Li L, Hamilton RF Jr, Taylor DE, Holian A: Acrolein-induced cell death in human alveolar macrophages. . Toxicol Appl Pharmacol. 1997 Aug;145(2):331-9. |
0(0,0,0,0) | Details |