Protein Information

Name aspartate aminotransferase
Synonyms Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
12365456 Southwell JL, Yeargans GS, Kowalewski C, Seidler NW: Acrolein modifies and inhibits cytosolic aspartate aminotransferase. . J Enzyme Inhib Med Chem. 2002 Feb;17(1):19-23.
112(1,2,2,2) Details
12559987 Seidler NW, Kowalewski C: Methylglyoxal-induced glycation affects protein topography. Arch Biochem Biophys. 2003 Feb 1;410(1):149-54.

We examined the effects of methylglyoxal on cytosolic aspartate aminotransferase (cAAT), which is an enzyme previously shown to be modified by glyceraldehyde, acrolein, and ribose 5-phosphate.
31(0,1,1,1) Details
17140783 Subash Babu P, Prabuseenivasan S, Ignacimuthu S: Cinnamaldehyde--a potential antidiabetic agent. Phytomedicine. 2007 Jan;14(1):15-22. Epub 2006 Nov 30.


Also cinnamaldehyde restored the altered plasma enzyme (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase and acid phosphatase) levels to near normal.
1(0,0,0,1) Details
9169072 Sneed RA, Grimes SD, Schultze AE, Brown AP, Ganey PE: Bacterial endotoxin enhances the hepatotoxicity of allyl alcohol. . Toxicol Appl Pharmacol. 1997 May;144(1):77-87.

Rats were pretreated with LPS (100 micrograms/kg) 2 hr before treatment with a minimally toxic dose of allyl alcohol mg/kg), and liver toxicity was assessed 18 hr later from activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in plasma and from histologic changes in liver sections.
LPS treatment did not affect the activity of alcohol dehydrogenase and did not affect the rate of production of NADH in isolated livers perfused with allyl alcohol; thus, LPS does not appear to increase the metabolic bioactivation of allyl alcohol into acrolein.
1(0,0,0,1) Details