| Name | polymerases |
|---|---|
| Synonyms | ERVK 2; ERVK2; HERV K; Polymerase; Polymerases |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18788757 | Minko IG, Yamanaka K, Kozekov ID, Kozekova A, Indiani C, O'Donnell ME, Jiang Q, Goodman MF, Rizzo CJ, Lloyd RS: Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family. Chem Res Toxicol. 2008 Oct;21(10):1983-90. Epub 2008 Sep 13. |
83(1,1,1,3) | Details |
| 19397281 | Minko IG, Kozekov ID, Harris TM, Rizzo CJ, Lloyd RS, Stone MP: Chemistry and biology of DNA containing 1,N adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and Chem Res Toxicol. 2009 May;22(5):759-78. DNA polymerases of the DinB family, pol IV in E. coli and pol kappa in human, are implicated in error-free bypass of model acrolein-mediated N (2)-dG secondary adducts, the interstrand cross-links, and the peptide conjugates. |
31(0,1,1,1) | Details |
| 9548749 | Langouet S, Mican AN, Muller M, Fink SP, Marnett LJ, Muhle SA, Guengerich FP: Misincorporation of nucleotides opposite five-membered exocyclic ring derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo [1, 2-a] and 5,6,7,9-tetrahydro-7--9-oxoimidazo [1, 2-a] Biochemistry. 1998 Apr 14;37(15):5184-93. A variety of exocyclic modified bases have been shown to be formed in DNA from various procarcinogens (e.g., acrolein, malonaldehyde, vinyl urethan) and are also found in untreated animals and humans, presumably arising as a result of lipid peroxidation. 1, N2-Ethenoguanine (1,N2-epsilon-Gua), a product known to be formed from several 2-carbon electrophiles, was placed in a known site (6256) in bacteriophage M13MB19 and mutations were analyzed in Escherichia coli, with 2.05% G--> A, 0.74% G--> T, and 0.09% G--> C changes found in uvrA- bacteria. 5,6,7, 9-Tetrahydro-7--9-oxoimidazo [1,2-a] (HO-ethanoGua), formally the hydrated derivative of 1,N2-epsilon-Gua, is a stable DNA product also derived from vinyl halides. |
4(0,0,0,4) | Details |
| 12584190 | Yang IY, Miller H, Wang Z, Frank EG, Ohmori H, Hanaoka F, Moriya M: Mammalian translesion DNA synthesis across an acrolein-derived adduct. J Biol Chem. 2003 Apr 18;278(16):13989-94. Epub 2003 Feb 12. To probe the cellular mechanism underlying the error-free and error-prone translesion DNA syntheses, in vitro primer extension experiments using purified DNA polymerases and site-specific alpha-OH-PdG were conducted. |
3(0,0,0,3) | Details |
| 15199127 | Washington MT, Minko IG, Johnson RE, Wolfle WT, Harris TM, Lloyd RS, Prakash S, Prakash L: Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. Mol Cell Biol. 2004 Jul;24(13):5687-93. To check the validity of this idea, we examined whether Poliota could incorporate nucleotides opposite the gamma-HOPdG adduct, which is formed from an initial reaction of acrolein with the N (2) of |
2(0,0,0,2) | Details |
| 16354708 | Wolfle WT, Johnson RE, Minko IG, Lloyd RS, Prakash S, Prakash L: Replication past a trans- minor-groove adduct by the sequential action of human DNA polymerases iota and kappa. Mol Cell Biol. 2006 Jan;26(1):381-6. Previously, we have shown that proficient and error-free replication through the gamma-HOPdG (gamma--1,N2-propano- adduct, which is formed from the reaction of acrolein with the N2 of is mediated by the sequential action of human Poliota and Polkappa, in which Poliota incorporates the nucleotide opposite the lesion site and Polkappa carries out the subsequent extension reaction. |
2(0,0,0,2) | Details |
| 11889127 | Kanuri M, Minko IG, Nechev LV, Harris TM, Harris CM, Lloyd RS: Error prone translesion synthesis past gamma-hydroxypropano the primary acrolein-derived adduct in mammalian cells. J Biol Chem. 2002 May 24;277(21):18257-65. Epub 2002 Mar 11. In vitro gamma-HOPdG strongly blocks DNA synthesis by two major polymerases, pol delta and pol epsilon. |
2(0,0,0,2) | Details |
| 16166652 | Wolfle WT, Johnson RE, Minko IG, Lloyd RS, Prakash S, Prakash L: Human DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA. Mol Cell Biol. 2005 Oct;25(19):8748-54. Acrolein, an alpha,beta-unsaturated is generated in vivo as the end product of lipid peroxidation and from oxidation of polyamines. Previously, we have shown that proficient replication through the gamma-HOPdG adduct can be mediated by the sequential action of human DNA polymerases (Pols) iota and kappa, in which Poliota incorporates either pyrimidine opposite gamma-HOPdG, but Polkappa extends only from the |
2(0,0,0,2) | Details |
| 15282292 | Washington MT, Minko IG, Johnson RE, Haracska L, Harris TM, Lloyd RS, Prakash S, Prakash L: Efficient and error-free replication past a minor-groove N2- adduct by the sequential action of yeast Rev1 and DNA polymerase zeta. Mol Cell Biol. 2004 Aug;24(16):6900-6. Rev1, a member of the Y family of DNA polymerases, functions in lesion bypass together with DNA polymerase zeta (Pol zeta). To test this idea, we examined whether Rev1 could incorporate a C opposite the gamma--1,N (2)-propano-2'deoxyguanosine DNA minor-groove adduct, which is formed from the reaction of acrolein with the N (2) of |
1(0,0,0,1) | Details |
| 6736107 | Bielicki L, Voelcker G, Hohorst HJ: Activated cyclophosphamide: an enzyme-mechanism-based suicide inactivator of DNA polymerase/3'-5' exonuclease. J Cancer Res Clin Oncol. 1984;107(3):195-8. Acrolein and an alkylating moiety are released in the process. Thus we suggest that toxification of activated CP by DNA polymerases/3'-5' exonucleases present mainly in proliferating cells might lead to the specific alkylation of macromolecules involved in the cell proliferation process, such as the DNA polymerase subsite of these enzymes and probably also the DNA bound to the enzymes. |
1(0,0,0,1) | Details |
| 20158384 | Liu XY, Zhu MX, Xie JP: Mutagenicity of acrolein and acrolein-induced DNA adducts. Toxicol Mech Methods. 2010 Jan;20(1):36-44. These two DNA adducts behave differently in mutagenicity. gamma-HOPdG is the major DNA adduct and it can lead to interstrand DNA-DNA and DNA-peptide/protein cross-links, which may induce strong mutagenicity; however, gamma-HOPdG can be repaired by some DNA polymerases complex and lessen its mutagenic effects. alpha-HOPdG is formed much less than gamma-HOPdG, but difficult to be repaired, which contributes to accumulation in vivo. |
1(0,0,0,1) | Details |
| 12401796 | Minko IG, Washington MT, Kanuri M, Prakash L, Prakash S, Lloyd RS: Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta. J Biol Chem. 2003 Jan 10;278(2):784-90. Epub 2002 Oct 24. In vitro, this adduct has previously been shown to pose a severe block to translesion synthesis by a number of polymerases (pol). |
1(0,0,0,1) | Details |
| 11124950 | Yang IY, Hossain M, Miller H, Khullar S, Johnson F, Grollman A, Moriya M: Responses to the major acrolein-derived adduct in Escherichia coli. J Biol Chem. 2001 Mar 23;276(12):9071-6. Epub 2000 Dec 21. |
0(0,0,0,0) | Details |