Protein Information

Name vimentin
Synonyms VIM; Vimentin; Vimentins

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
19686041 Burcham PC, Raso A, Thompson CA: Intermediate filament carbonylation during acute acrolein toxicity in A549 lung cells: functional consequences, chaperone redistribution, and protection by bisulfite. Antioxid Redox Signal. 2010 Mar;12(3):337-47.

The carbonyl scavenger bisulfite suppressed acrolein toxicity, intermediate filament adduction, vimentin cross-linking, Hsp90 redistribution, and loss of cellular adhesive strength, while also suppressing vimentin hyperphosphorylation.
32(0,1,1,2) Details
11325063 Poggi P, Rota MT, Boratto R: Microtubules and vimentin associated filaments (VIFs) in cultured human gingival fibroblasts (HGFs) after exposure to acrolein and acetaldehyde. Ann Anat. 2001 Mar;183(2):159-63.
8(0,0,1,3) Details
12113559 Poggi P, Rota MT, Boratto R: The volatile fraction of cigarette smoke induces alterations in the human gingival fibroblast cytoskeleton. J Periodontal Res. 2002 Jun;37(3):230-5.

Since the survival and reproduction of gingival fibroblasts are fundamental in maintaining the integrity of the oral connective tissue, as well as in wound healing, the effects on the cytoskeleton of acrolein and acetaldehyde, which are the volatile fractions of cigarette smoke, were examined in vitro for human gingival fibroblasts (HGFs).
The influence on cytoskeletal structures (tubulin, actin and vimentin intermediate filaments) was investigated with the indirect immunofluorescence technique.
2(0,0,0,2) Details
11453231 Rota MT, Poggi P, Boratto R: Human gingival fibroblast cytoskeleton is a target for volatile smoke components. J Periodontol. 2001 Jun;72(6):709-13.

Since gingival fibroblast survival and reproduction are fundamental to maintaining the oral connective tissue as well as to wound healing, the effects of acrolein and acetaldehyde, volatile fractions of cigarette smoke, on cytoskeleton were examined in human gingival fibroblasts (HGFs) in vitro.
The influence of both substances on cytoskeletal structures, tubulin and vimentin intermediate filaments (VIF), was investigated using indirect immunofluorescence technique.
2(0,0,0,2) Details
18468780 Gratzke C, Streng T, Waldkirch E, Sigl K, Stief C, Andersson KE, Hedlund P: Transient receptor potential A1 (TRPA1) activity in the human urethra--evidence for a functional role for TRPA1 in the outflow region. Eur Urol. 2009 Mar;55(3):696-704. Epub 2008 Apr 30.


Interspersed between strands of smooth muscle cells of the urethral wall, TRPA1- and vimentin-IR cells containing central nuclei and slender cytoplasmatic extensions were observed.
1(0,0,0,1) Details
20015449 Burcham PC, Raso A, Thompson CA: Toxicity of smoke extracts towards A549 lung cells: role of acrolein and suppression by carbonyl scavengers. Chem Biol Interact. 2010 Feb 12;183(3):416-24. Epub 2009 Dec 16.

The toxicity was accompanied by pronounced carbonylation of several cytoskeletal targets, namely vimentin and keratins-7, -8 and -18.
1(0,0,0,1) Details