| Name | NFkappaB (protein family or complex) |
|---|---|
| Synonyms | NF kappa B; NFKB; NFkappaB; Nuclear factor NF kappa B |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15650393 | Valacchi G, Pagnin E, Phung A, Nardini M, Schock BC, Cross CE, van der Vliet A: Inhibition of NFkappaB activation and IL-8 expression in human bronchial epithelial cells by acrolein. Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):25-31. |
274(3,4,4,4) | Details |
| 17318410 | Sarkar P, Hayes BE: Induction of COX-2 by acrolein in rat lung epithelial cells. . Mol Cell Biochem. 2007 Jul;301(1-2):191-9. Epub 2007 Feb 21. The activation of NFkappaB by acrolein was induced as a result of degradation of IkappaBalpha over the time of treatment. |
112(1,2,2,2) | Details |
| 17920563 | Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, Lee JY: suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem Pharmacol. 2008 Jan 15;75(2):494-502. Epub 2007 Sep 2. TLRs have two major downstream signaling pathways, MyD88- and TRIF-dependent pathways leading to the activation of NFkappaB and IRF3 and the expression of inflammatory mediators. |
5(0,0,0,5) | Details |
| 15910882 | Partridge CR, Williams ES, Barhoumi R, Tadesse MG, Johnson CD, Lu KP, Meininger GA, Wilson E, Ramos KS: Novel genomic targets in oxidant-induced vascular injury. J Mol Cell Cardiol. 2005 Jun;38(6):983-96. Epub 2005 Apr 19. To study the complex interaction between oxidative injury and the pathogenesis of vascular disease, vascular gene expression was examined in male Sprague-Dawley rats given 35 or 70 mg/kg allylamine, a synthetic amine converted to acrolein and peroxide within the vascular wall. Vascular lesions and extensive vascular remodeling, coupled to increased production of 8-epi-PGF2alpha, nuclear localization of NFkappaB, and alterations in homeostasis, were observed in animals treated with allylamine for up to 20 days. |
2(0,0,0,2) | Details |