| Name | integrin |
|---|---|
| Synonyms | Alpha 11 precursor; HsT18964; ITGA11; Integrin; Integrin alpha 11; Integrin alpha 11 precursor; MSTP018; HsT18964s… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15910882 | Partridge CR, Williams ES, Barhoumi R, Tadesse MG, Johnson CD, Lu KP, Meininger GA, Wilson E, Ramos KS: Novel genomic targets in oxidant-induced vascular injury. J Mol Cell Cardiol. 2005 Jun;38(6):983-96. Epub 2005 Apr 19. To study the complex interaction between oxidative injury and the pathogenesis of vascular disease, vascular gene expression was examined in male Sprague-Dawley rats given 35 or 70 mg/kg allylamine, a synthetic amine converted to acrolein and peroxide within the vascular wall. Transcriptional profiling, immunohistochemistry, and in situ hybridization showed that genes involved in adhesion and extracellular matrix (ECM) (alpha (1) integrin, collagen), cytoskeletal rearrangements (alpha-smooth muscle actin, alpha-tropomyosin), and signal transduction (NFkappaB, osteopontin, and LINE) were altered by oxidant treatment. |
2(0,0,0,2) | Details |
| 18266977 | Gunther M, Wagner E, Ogris M: Acrolein: unwanted side product or contribution to antiangiogenic properties of metronomic cyclophosphamide therapy?. J Cell Mol Med. 2008 Dec;12(6B):2704-16. Epub 2008 Feb 4. Moreover, acrolein caused disassembly of the F-actin cytoskeleton and inhibition of alphavbeta3 integrin clustering at focal adhesions points in endothelial cells. |
81(1,1,1,1) | Details |
| 9575878 | Carnevali S, Nakamura Y, Mio T, Liu X, Takigawa K, Romberger DJ, Spurzem JR, Rennard SI: Cigarette smoke extract inhibits fibroblast-mediated collagen gel contraction. Am J Physiol. 1998 Apr;274(4 Pt 1):L591-8. Production of a known inhibitor of fibroblast contraction, was unchanged by CSE as was cell surface integrin expression. Therefore, we also examined the effects of acrolein and two volatile components of cigarette smoke. |
1(0,0,0,1) | Details |