Protein Information

Name ADH1
Synonyms ADH 1; ADH1; ADH1A; Alcohol dehydrogenase 1; Alcohol dehydrogenase 1A; Alcohol dehydrogenase alpha subunit; Alcohol dehydrogenase 1s; Alcohol dehydrogenase 1As…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
12604195 Niknahad H, Siraki AG, Shuhendler A, Khan S, Teng S, Galati G, Easson E, Poon R, O'Brien PJ: Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. Chem Biol Interact. 2003 Feb 1;143-144:107-17.

Although acrolein-induced cytotoxicity was only delayed by antioxidants or glycolytic substrates (e.g. fructose), it was prevented by NADH generators (e.g. xylitol and sorbitol) due to increased metabolism by ADH1.
113(1,2,2,3) Details