| Name | ALDH2 |
|---|---|
| Synonyms | ALDH class 2; ALDH 2; ALDH E2; ALDH2; ALDHI; ALDM; Aldehyde dehydrogenase 2; DHAM… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19428347 | Truong D, Hindmarsh W, O'Brien PJ: The molecular mechanisms of diallyl disulfide and diallyl sulfide induced hepatocyte cytotoxicity. Chem Biol Interact. 2009 Jun 15;180(1):79-88. Epub 2009 Feb 23. Chloral hydrate, the aldehyde dehydrogenase 2 inhibitor, however had the opposite effects, which could suggest that acrolein contributed to DAS hepatocyte cytotoxicity. |
31(0,1,1,1) | Details |
| 12604195 | Niknahad H, Siraki AG, Shuhendler A, Khan S, Teng S, Galati G, Easson E, Poon R, O'Brien PJ: Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. Chem Biol Interact. 2003 Feb 1;143-144:107-17. Decadienal-induced cytotoxicity was also more increased by mitochondrial ALDH2 inhibitors than acrolein and was more increased by decreasing mitochondrial NAD+ with rotenone or decreased by increasing mitochondrial NAD+ with |
31(0,1,1,1) | Details |
| 20062057 | Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD: Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat Struct Mol Biol. 2010 Feb;17(2):159-64. Epub 2010 Jan 10. This mitochondrial enzyme metabolizes toxic biogenic and environmental aldehydes, including the endogenously produced (4HNE) and the environmental pollutant acrolein, and also bioactivates nitroglycerin. |
5(0,0,0,5) | Details |
| 12527414 | Nguyen E, Picklo MJ Sr: Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation. Biochim Biophys Acta. 2003 Jan 20;1637(1):107-12. Previous studies demonstrate that mitochondrial class 2 aldehyde dehydrogenase (ALDH2) is susceptible to inactivation by these alkenals. Acrolein potently inhibited SSADH activity (IC (50)=15 microM) in rat brain mitochondrial preparations. |
1(0,0,0,1) | Details |