Protein Information

Name osteocalcin
Synonyms BGLAP; BGP; Bone Gla protein; Bone gamma carboxyglutamaic acid protein; Gamma carboxyglutamicacid protein; Gamma carboxyglutamic acid containing protein; Osteocalcin; Osteocalcin precursor…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
20194099 Sun L, Yu F, Xu Z, Zeng X, Ferreri M, Han B: Alteration of osteocalcin mRNA expression in ovine osteoblasts in dependence of sodium fluoride and sodium selenite medium supplementation. Acta Biol Hung. 2010 Mar;61(1):52-63.

Objective of this study was to assess the quantification of osteocalcin (OCN) expression by ovine osteoblasts cultured with different concentrations of sodium fluoride (F) and sodium selenite (Se) to evaluate the interaction of these agents on OCN expression in vitro .
38(0,1,2,3) Details
12641503 von Tirpitz C, Klaus J, Steinkamp M, Hofbauer LC, Kratzer W, Mason R, Boehm BO, Adler G, Reinshagen M: Therapy of osteoporosis in patients with Crohn's disease: a randomized study comparing sodium fluoride and ibandronate. Aliment Pharmacol Ther. 2003 Mar 15;17(6):807-16.

Therapy with sodium fluoride was associated with an increase in osteocalcin (N.S.), whereas administration of ibandronate was associated with a decrease in the resorption parameter, carboxy-terminal cross-linked type-I collagen telopeptide (P < 0.05).
31(0,1,1,1) Details
17418719 Kebsch M, Wilkinson M, Petocz P, Darendeliler MA: The effect of fluoride administration on rat serum osteocalcin expression during orthodontic movement. Am J Orthod Dentofacial Orthop. 2007 Apr;131(4):515-24.

These animals did not undergo orthodontic tooth movement and were given fluoridated (100 ppm sodium fluoride) and nonfluoridated water ad libitum.
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10656205 von Tirpitz C, Klaus J, Bruckel J, Rieber A, Scholer A, Adler G, Bohm BO, Reinshagen M: Increase of bone mineral density with sodium fluoride in patients with Crohn's disease. Eur J Gastroenterol Hepatol. 2000 Jan;12(1):19-24.

Bone-specific alkaline phosphatase and osteocalcin were used as markers for bone turnover.
2(0,0,0,2) Details
9437512 Ammann P, Rizzoli R, Caverzasio J, Bonjour JP: Fluoride potentiates the osteogenic effects of IGF-I in aged ovariectomized rats. Bone. 1998 Jan;22(1):39-43.

These changes were associated with a concomitant increase in osteocalcin, taken as a reflection of bone formation.
Adult ovariectomized osteopenic rats were treated with sodium fluoride at a dose of 6 mg/kg per day in drinking water for 8 weeks in association with IGF-I either at a dose of 2 mg/kg per day, which is capable of increasing bone mass, or at a lower dose without detectable skeletal effects.
1(0,0,0,1) Details
14965088 Fleming RH, McCormack HA, McTeir L, Whitehead CC: Effects of dietary particulate limestone, vitamin K3 and fluoride and photostimulation on skeletal morphology and osteoporosis in laying hens. Br Poult Sci. 2003 Dec;44(5):683-9.

Female chicks of a White Leghorn strain were fed three different diets from one day old: control, additional vitamin K3 (10 mg/kg), and a diet containing a combination of additional vitamin K3, sodium fluoride (10 mg/kg) and limestone in particulate rather than powdered form.
Plasma osteocalcin concentrations were unaffected by vitamin K3 supplementation during growth. 4.
1(0,0,0,1) Details
8637511 Mihashi M, Tsutsui T: Clastogenic activity of sodium fluoride to rat vertebral body-derived cells in culture. Mutat Res. 1996 May;368(1):7-13.

Confluent RVBd cells were responsive to 10 (-8) M 1 alpha.25-dihydroxyvitamin D3 with a 7.7-fold increase in osteocalcin production over base line values.
1(0,0,0,1) Details
9312196 Zerwekh JE, Padalino P, Pak CY: The effect of intermittent slow-release sodium fluoride and continuous calcium citrate therapy on calcitropic hormones, biochemical markers of bone metabolism, and blood chemistry in postmenopausal osteoporosis. Calcif Tissue Int. 1997 Oct;61(4):272-8.

0(0,0,0,0) Details