| Name | GTPase |
|---|---|
| Synonyms | RAC3; RAC3; Ras related C3 botulinum substrate 3; Ras related C3 botulinum toxin substrate 3; p21 Rac3; Ras related C3 botulinum substrate 3s; Ras related C3 botulinum toxin substrate 3s; p21 Rac3s… |
| Name | sodium fluoride |
|---|---|
| CAS | sodium fluoride (NaF) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10494860 | Vincent S, Settleman J: Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization. Eur J Cell Biol. 1999 Aug;78(8):539-48. We observed that exposure of cultured fibroblasts to sodium fluoride (NaF) results in a rapid and potent stimulation of actin stress fiber formation. This effect is mediated by the Rho GTPase and is associated with the inactivation of cellular RhoGAP activity. |
3(0,0,0,3) | Details |
| 9482864 | Vincent S, Brouns M, Hart MJ, Settleman J: Evidence for distinct mechanisms of transition state stabilization of GTPases by Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2210-5. GTPase-activating proteins (GAPs) function by stabilizing the GTPase transition state. |
2(0,0,0,2) | Details |
| 9016786 | Chen HK, Yeh NH: The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. Biochem Biophys Res Commun. 1997 Jan 13;230(2):370-5. |
2(0,0,0,2) | Details |
| 8706742 | Wolfl J, Dagher MC, Fuchs A, Geiszt M, Ligeti E: In vitro activation of the oxidase by Eur J Biochem. 1996 Jul 15;239(2):369-75. In contrast, effectively inhibits Rac-GTPase activity enhanced by a membrane component. |
1(0,0,0,1) | Details |
| 9231714 | Blanc EM, Kelly JF, Mark RJ, Waeg G, Mattson MP: an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic and metabotropic glutamate receptors: possible action on G alpha (q/11). J Neurochem. 1997 Aug;69(2):570-80. At subtoxic concentrations, HNE markedly inhibited GTPase activity, release, and elevation of intracellular levels induced by carbachol (muscarinic agonist) and (RS)-3,5-dihydroxyphenyl (metabotropic glutamate receptor agonist). |
1(0,0,0,1) | Details |
| 10805281 | Fuse I, Higuchi W, Aizawa Y: Pathogenesis of a bleeding disorder characterized by platelet unresponsiveness to Semin Thromb Hemost. 2000;26(1):43-5. The platelets of three patients had the ability to bind exogenous but synthetic mimetic-induced postreceptor biochemical events, such as IP3 formation, Ca2+ mobilization, formation, and GTPase activities, were selectively defective, suggesting impaired coupling between the receptor and phospholipase C activation. |
1(0,0,0,1) | Details |
| 9753466 | Natochin M, Artemyev NO: A single mutation Asp229 --> Ser confers upon Gs alpha the ability to interact with regulators of G protein signaling. Biochemistry. 1998 Sep 29;37(39):13776-80. In a single-turnover assay, RGS16 maximally stimulated GTPase activity of Gs alpha Asp229Ser by approximately 5-fold with an EC50 value of 7.5 microM. |
1(0,0,0,1) | Details |
| 10555980 | Graham DL, Eccleston JF, Chung CW, Lowe PN: -dependent binding of small G proteins to their GTPase-activating proteins. Biochemistry. 1999 Nov 9;38(45):14981-7. GTPase-activating proteins (GAPs) enhance the intrinsic GTPase activity of small G proteins, such as Ras and Rho, by contributing a catalytic to the active site. |
1(0,0,0,1) | Details |
| 8816753 | Poon PP, Wang X, Rotman M, Huber I, Cukierman E, Cassel D, Singer RA, Johnston GC: Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10074-7. The GTPase cycle of ARF proteins that allows the uncoating and fusion of a transport vesicle with a target membrane is mediated by ARF-dependent GTPase-activating proteins (GAPs). |
1(0,0,0,1) | Details |
| 8972723 | Di Stefano A, La Gaetana R, Bovalini L, Lusini P, Martelli P: Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells. Biochim Biophys Acta. 1996 Nov 8;1314(1-2):105-8. This paper reports that pretreatment of HeLa cells with pertussis toxin reverses both the inhibition of NaF-stimulated adenylyl cyclase activity and the stimulation of GTPase by khellin alone and plus UVA light, as previously reported. |
1(0,0,0,1) | Details |
| 10515580 | Szaszi K, Korda A, Wolfl J, Paclet MH, Morel F, Ligeti E: Possible role of RAC-GTPase-activating protein in the termination of production in phagocytic cells. Free Radic Biol Med. 1999 Oct;27(7-8):764-72. Activation of the enzyme was carried out under in vitro conditions and a shift from the active to the inactive form of the GTP-binding protein was attained (i) by addition of an excess of GDP to the assembled enzyme complex or (ii) by variation of the Rac-GTPase activating (Rac-GAP) capacity of the constituents of the cell-free system. |
1(0,0,0,1) | Details |