Protein Information

Name fibronectin
Synonyms CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
11821240 Cao J, Doyle RJ: Fluoride modifies adhesion of Streptococcus pyogenes. FEMS Immunol Med Microbiol. 2002 Jan 14;32(2):175-7.

Streptococcus pyogenes grown in the presence of subinhibitory concentrations of sodium fluoride had a diminished ability, compared to control cells, to adhere to buccal cells, collagen, fibronectin, and laminin.
6(0,0,1,1) Details
8925139 Cook-Mills JM, Gallagher JS, Feldbush TL: Isolation and characterization of high endothelial cell lines derived from mouse lymph nodes. In Vitro Cell Dev Biol Anim. 1996 Mar;32(3):167-77.

The cells were not myeloid in origin because they lacked sodium fluoride-inhibitable nonspecific esterase activity, myeloperoxidase activity, and F4/80 antigen.
HEV cells in lymph node tissue sections expressed endoglin, PECAM-1, ICAM-1, VCAM-1, laminin, fibronectin, collagen IV, H2Kd, MECA 79, MECA 325, and vWF.
2(0,0,0,2) Details
11314416 Guimaraes AR, Modesto A, Vieira AR: Formation of alkali-soluble fluoride on the surface of human dental enamel after treatment with fluoridated gels: influence of the pH variation and of the treatment time. J Clin Pediatr Dent. 2000 Summer;24(4):303-7.


The aim of this study was to quantify, in vitro, the formation of CaF2 after the application of three fluoridated gels: one neutral, one acidulated and another highly acidulated, on a bovine enamel dental surface treated with a Dijkman's demineralizing solution (1990). 145 sections were utilized, obtained from 145 sound teeth and divided into seven groups: C (enamel without treatment); FN1 (enamel demineralized and treated with neutral gel for 1 minute); FN4 (enamel demineralized and treated with neutral gel for 4 minutes); FFA1 (enamel demineralized and treated with acidulated gel for 1 minute); FFA4 (enamel demineralized and treated with acidulated gel for 4 minutes); FAA1 (enamel demineralized and treated with highly acidulated gel for 1 minute) and FAA4 (enamel demineralized and treated with highly acidulated gel for 4 minutes).
2(0,0,0,2) Details
11867637 Thongboonkerd V, Luengpailin J, Cao J, Pierce WM, Cai J, Klein JB, Doyle RJ: Fluoride exposure attenuates expression of Streptococcus pyogenes virulence factors. J Biol Chem. 2002 May 10;277(19):16599-605. Epub 2002 Feb 26.

A 16-h exposure to sodium fluoride caused decreased expression of proteins required to respond to cellular stress, including anti-oxidants, glycolytic enzymes, transcriptional and translational regulators, and protein folding.
Fluoride decreased expression of glyceraldehyde-3-phosphate dehydrogenase, which acts to bind fibronectin and promote bacterial adherence.
1(0,0,0,1) Details
19887723 Arakawa Y, Bhawal UK, Ikoma T, Kimoto K, Kuroha K, Kubota T, Hamada N, Kubota E, Arakawa H: Low concentration fluoride stimulates cell motility of epithelial cells in vitro. Biomed Res. 2009 Oct;30(5):271-7.

The aim of this study was to determine the effect of low level sodium fluoride (NaF) on the proliferation and migration of epithelial cells in vitro.
Quantitative real-time PCR revealed that low concentration of NaF up-regulated fibronectin mRNA expression in fluoride-treated cells compared with controls.
1(0,0,0,1) Details