Protein Information

Name aquaporin (protein family or complex)
Synonyms aquaporin; aquaporins

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
17387993 Veselovskii VA, Veselova TV: [The disruption of aquaporin function in cell membranes as a cause of changes in germinability of pea seeds after exposure to low doses of gamma-radiation]. Radiats Biol Radioecol. 2007 Jan-Feb;47(1):28-33.

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11562400 Kim SW, Cho SH, Oh BS, Yeum CH, Choi KC, Ahn KY, Lee J: Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction. J Am Soc Nephrol. 2001 Oct;12(10):2019-28.

The protein expression of G (salpha) was decreased in the cortex, outer medulla, and inner medulla, whereas that of adenylyl cyclase VI was decreased in the outer and inner medullae. cAMP generation stimulated by arginine vasopressin was decreased in the cortex, outer medulla, and inner medulla. cAMP generation in response to forskolin was decreased in the outer and inner medullae, whereas that in response to sodium fluoride was decreased in the cortex, outer medulla, and inner medulla.
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12745716 Yeum CH, Kim SW, Lee SC, Choi KC, Ahn KY, Lee J: Diminished expression of aquaporin water channels in ureteral-obstructed kidney in rats. Scand J Urol Nephrol. 2003;37(2):99-105.

The expression of AQP1 and AQP3 was decreased in the outer medulla and inner medulla. cAMP generation in response to AVP, sodium fluoride or forskolin was greatly decreased.
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11316845 Kim SW, Lee JU, Nah MY, Kang DG, Ahn KY, Lee HS, Choi KC: Cisplatin decreases the abundance of aquaporin water channels in rat kidney. J Am Soc Nephrol. 2001 May;12(5):875-82.

However, the cyclic adenosine monophosphate generation in response to forskolin was not affected, whereas that to sodium fluoride was diminished significantly.
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19955819 Ma SK, Bae EH, Kim IJ, Choi C, Lee J, Kim SW: Altered renal expression of aquaporin water channels and sodium transporters in rats with two-kidney, one-clip hypertension. Kidney Blood Press Res. 2009;32(6):411-20. Epub 2009 Dec 3.

The adenylyl cyclase activity provoked by arginine vasopressin, sodium fluoride or forskolin was blunted in the clipped kidney, but remained unaltered in the contralateral kidney.
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11388643 Lee J, Yoo KS, Kang DG, Kim SW, Choi KC: Gentamicin decreases the abundance of aquaporin water channels in rat kidney. Jpn J Pharmacol. 2001 Apr;85(4):391-8.

The cAMP generation in response to arginine vasopressin or sodium fluoride was decreased by gentamicin, while that to forskolin was not significantly altered.
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18971210 Jensen AM, Bae EH, Fenton RA, Norregaard R, Nielsen S, Kim SW, Frokiaer J: Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction. Am J Physiol Renal Physiol. 2009 Jan;296(1):F127-34. Epub 2008 Oct 29.

Release of bilateral ureteral obstruction (BUO) is associated with nephrogenic diabetes insipidus (NDI) and a reduced abundance of the vasopressin-regulated aquaporins.
Furthermore, cAMP generation in sodium fluoride- and forskolin-stimulated inner medullary membrane fractions was studied after release of BUO.
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11574818 Kim SW, Yeum CH, Kim S, Oh Y, Choi KC, Lee J: Amphotericin B decreases adenylyl cyclase activity and aquaporin-2 expression in rat kidney. J Lab Clin Med. 2001 Oct;138(4):243-9.

The cAMP generation in response to AVP or sodium fluoride was decreased, whereas that to forskolin was not significantly altered.
The present study was intended to examine whether the amphotericin-induced urinary concentration defect can be related to an altered regulation of aquaporin (AQP) water channels in the kidney.
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12208125 Yeum CH, Kim SW, Kim NH, Choi KC, Lee J: Increased expression of aquaporin water channels in hypothyroid rat kidney. Pharmacol Res. 2002 Jul;46(1):85-8.

The adenylyl cyclase activity provoked by arginine vasopressin (AVP), sodium fluoride, or forskolin was blunted in the hypothyroid kidney, while plasma levels of AVP were not significantly changed.
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18450565 Voicu MC, Zwiazek JJ, Tyree MT: Light response of hydraulic conductance in bur oak (Quercus macrocarpa) leaves. Tree Physiol. 2008 Jul;28(7):1007-15.


Atrazine (a photosystem II inhibitor), fusicoccin (which stimulates plasma membrane-bound H (+)-ATPase) and HgCl (2) (an aquaporin blocker) reduced the light response of leaf lamina hydraulic conductance.
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