Protein Information

Name interleukin 1beta
Synonyms Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
12472997 Mostefaoui Y, Claveau I, Ross G, Rouabhia M: Tissue structure, and IL-1beta, IL-8, and TNF-alpha secretions after contact by engineered human oral mucosa with dentifrices. J Clin Periodontol. 2002 Nov;29(11):1035-41.

3(0,0,0,3) Details
10447558 Hirano S, Ando M, Kanno S: Inflammatory responses of rat alveolar macrophages following exposure to fluoride. Arch Toxicol. 1999 Aug;73(6):310-5.


I.t. instillation of fluoride significantly enhanced mRNA expression of cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, cytokine-induced neutrophil chemoattractant, and macrophage inflammatory proteins-1alpha and -2.
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9885886 Bernardin G, Strosberg AD, Bernard A, Mattei M, Marullo S: Beta-adrenergic receptor-dependent and -independent stimulation of adenylate cyclase is impaired during severe sepsis in humans. Intensive Care Med. 1998 Dec;24(12):1315-22.

We measured beta-adrenergic receptor (betaAR) number and affinity, and intracellular cAMP content at baseline and after the pharmacological stimulation of each component of the beta-adrenergic complex: betaAR with isoproterenol, Gs-protein with sodium fluoride (NaF), adenylate cyclase with forskolin.
Catecholamine (adrenaline, noradrenaline) and cytokine (TNFalpha, IL-1alpha, IL-1beta, IL-6) serum levels were measured.
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10946302 Sadeghi MM, Collinge M, Pardi R, Bender JR: Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. J Immunol. 2000 Sep 1;165(5):2712-8.


They are induced by the proinflammatory cytokines IL-1 and TNF-alpha, and NF-kappaB is required for the regulated expression of all three genes.
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10594545 Arnold R, Rihoux J, Konig W: Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549). Clin Exp Allergy. 1999 Dec;29(12):1681-91.


Confluent epithelial cell monolayer were pre-incubated with cetirizine (0.01 -1.0 micromol/L) for 30 min and afterwards activated with pro-inflammatory cytokines (TNF-alpha IL-1beta, IL-6, IFN-gamma) or different agonists (PMA, NaF, respiratory syncytial virus [RSV]) for 24 h.
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17291994 Li L, Rossoni G, Sparatore A, Lee LC, Del Soldato P, Moore PK: Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative. Free Radic Biol Med. 2007 Mar 1;42(5):706-19. Epub 2006 Dec 16.

S-diclofenac administration downregulated expression of genes encoding enzymes which synthesize nitric oxide, prostanoids, and H2S; reduced plasma IL-1beta/TNF-alpha; and elevated plasma IL-10.
Incubation of S-diclofenac (100 microM) with rat plasma or liver homogenate caused a time-dependent release of H2S, which was inhibited by sodium fluoride (10 mM).
1(0,0,0,1) Details