Protein Information

Name dopamine beta hydroxylase
Synonyms DBH; DBM; Dopamine beta hydroxylase; Dopamine beta monooxygenase; Dopamine beta hydroxylase precursor; dopamine beta hydroxylase (dopamine beta monooxygenase); DBH; Dopamine beta hydroxylases…

Compound Information

Name carbon disulfide
CAS carbon disulfide

Reference List

PubMed Abstract RScore(About this table)
3078292 Dalvi RR: Mechanism of the neurotoxic and hepatotoxic effects of carbon disulfide. . Drug Metabol Drug Interact. 1988;6(3-4):275-84.

The nonmicrosomal pathway involves nonenzymatic spontaneous reaction of carbon disulfide with amino or thiol groups that leads to formation of dithiocarbamates or GSH conjugates as well as inhibition of certain enzymes such as dopamine beta-hydroxylase.
81(1,1,1,1) Details
9072070 Maccari S, Giglioli W, Semrov E, Fornaciari G: [Collateral effects of disulfiram on the central nervous system in alcoholics that have become totally abstemious. Ann Ital Med Int. 1996 Oct-Dec;11(4):279-83.

Disulfiram and its metabolite carbon disulfide inhibit dopamine beta-hydroxylase, increasing the levels of dopamine and reducing those of norepinephrine in the central nervous system.
81(1,1,1,1) Details
886465 McKenna MJ, DiStefano V: Carbon disulfide. J Pharmacol Exp Ther. 1977 Aug;202(2):253-66.

A proposed mechanism for the action of carbon disulfide on dopamine beta-hydroxylase.
31(0,1,1,1) Details
9199118 Kuligowski D: [The influence of chronic exposure to carbon disulfide on metabolism of catecholamines and serotonin in women]. Ann Acad Med Stetin. 1996;42:139-56.

The aim of the presented study is to evaluate the linear correlation between: 1) serum dopamine-beta hydroxylase activity and the dopamine concentration in plasma as well as 24-hours adrenaline and noradrenaline excretion in the urine; and 2) between catechol-0-methyltransferase and monoaminoxidase activity and the 24-hours excretion of catecholamine in the urine; next the serum and platelet concentration of serotonin and the arterial blood pressure in women chronically exposed to carbon disulfide.
6(0,0,1,1) Details
8027511 Caroldi S, De Paris P, Zotti S, Zanella I, Brugnone F: Effects of disulfiram on serum dopamine-beta-hydroxylase and blood carbon disulphide concentrations in alcoholics. J Appl Toxicol. 1994 Mar-Apr;14(2):77-80.

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6517704 Caroldi S, Jarvis JA, Magos L: In vivo inhibition of dopamine-beta-hydroxylase in rat adrenals during exposure to carbon disulphide. Arch Toxicol. 1984 Oct;55(4):265-7.

2(0,0,0,2) Details
6732851 Caroldi S, Jarvis J, Magos L: Stimulation of dopamine-beta-hydroxylase in rat adrenals by repeated exposures to carbon disulphide. Biochem Pharmacol. 1984 Jun 15;33(12):1933-6.

2(0,0,0,2) Details
7842240 Stanosz S, Kuligowski D, Pieleszek A, Zuk E, Rzechula D, Chlubek D: Concentration of dopamine in plasma, activity of dopamine beta-hydroxylase in serum and urinary excretion of free catecholamines and vanillylmandelic acid in women chronically exposed to carbon disulphide. Int J Occup Med Environ Health. 1994;7(3):257-61.

1(0,0,0,1) Details
1152617 Catignani GL, Neal RA: Studies of the inhibition of dopamine beta hydroxylase by thiono-sulfur containing compounds. Life Sci. 1975 Jun 15;16(12):1915-21.

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3611599 Caroldi S, Magos L, Jarvis J, Forshaw P, Snowden RT: The potentiation of the non-behavioural effects of amphetamine by carbon disulphide. J Appl Toxicol. 1987 Feb;7(1):63-6.


In agreement with the inhibition of dopamine-beta-hydroxylase by exposure to CS2, the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypothalmus.
1(0,0,0,1) Details
7038525 Wood RW: Neurobehavioral toxicity of carbon disulfide. . Neurobehav Toxicol Teratol. 1981 Winter;3(4):397-405.

Dopamine beta-hydroxylase inhibition has been demonstrated in vivo and in vitro.
1(0,0,0,1) Details
3884075 Caroldi S, Jarvis J, Magos L: Carbon disulphide exposure affects the response of rat adrenal medulla to hypothermia and hypoglycaemia. Br J Pharmacol. 1985 Feb;84(2):357-63.


The effects of hypothermia and hypoglycaemia on adrenal catecholamines and dopamine-beta-hydroxylase were compared in control and carbon disulphide (CS2) exposed rats 24 h after the last of ten daily 4 h inhalation exposures to CS2, 2 mg 1 (-1) air.
1(0,0,0,1) Details
2745164 Wasilewska E, Stanosz S, Bargiel Z: Serum dopamine-beta-hydroxylase activity in women occupationally exposed to carbon disulphide. Ind Health. 1989;27(2):89-93.

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3340619 Chester AE, Meyers FH: Central sympathoplegic and norepinephrine-depleting effects of antioxidants. Proc Soc Exp Biol Med. 1988 Jan;187(1):62-8.

Carbon disulfide (CS2), tetraethyl lead (TEL), tetraethyl tin (TeET), dithiothreitol (DTT), and gossypol acetic acid (GAA) significantly decreased brain norepinephrine (NE) in rats.
A possible mechanism is reversible inhibition of dopamine beta-hydroxylase through the reduction of the copper ion of the enzyme.
1(0,0,0,1) Details