Protein Information

Name Microsomal monooxygenase
Synonyms ARO; Microsomal monooxygenase; Flavoprotein linked monooxygenase; ARO 1; ARO1; Aromatase; Aromatase cytochrome P450; CPV 1…

Compound Information

Name carbon disulfide
CAS carbon disulfide

Reference List

PubMed Abstract RScore(About this table)
3724435 Wronska-Nofer T, Klimczak J, Laurman W, Opalska B: [Interaction of carbon disulfide (CS2 with ethanol in the microsomal monooxygenase system, and its biological consequences]. Med Pr. 1986;37(1):1-11.
82(1,1,1,2) Details
3953292 Dalvi RR, Deoras DP: Metabolism of a dithiocarbamate fungicide thiram to carbon disulfide in the rat and its hepatotoxic implications. Acta Pharmacol Toxicol. 1986 Jan;58(1):38-42.

The following experiments were carried out to investigate whether carbon disulfide (CS2) is a metabolic product of microsomal monooxygenase catalyzed metabolism of thiram in rats.
81(1,1,1,1) Details
3472027 Laurman W, Wronska-Nofer T: Serum lipid and lipoprotein-cholesterol in rats jointly exposed to carbon disulphide and ethanol. Med Pr. 1986;37(6):337-41.


It is postulated that the observed changes are related to the effect of the evaluated agents on the microsomal monooxygenase system.
1(0,0,0,1) Details
6315019 Masuda Y, Nakayama N: Protective action of diethyldithiocarbamate and carbon disulfide against renal injury induced by chloroform in mice. Biochem Pharmacol. 1983 Nov 1;32(21):3127-35.

In CCl4-treated mice, in which liver microsomal monooxygenase activities were decreased markedly, and kidney microsomal aniline hydroxylase and p-nitroanisole demethylase activities were increased to about twice those of the untreated mice, renal toxicity of CHCl3 was greatly potentiated, and the latter effect was also blocked by both agents.
1(0,0,0,1) Details