Protein Information

Name muscles
Synonyms COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H…

Compound Information

Name carbon disulfide
CAS carbon disulfide

Reference List

PubMed Abstract RScore(About this table)
6464681 Jirmanova I, Lukas E: Ultrastructure of carbon disulphie neuropathy. Acta Neuropathol. 1984;63(3):255-63.


Adult Wistar rats were exposed to carbon disulphide (CS2) vapour at a concentration of 2.4 mg/l of air for 5 days a week (6 h a day), and the ultrastructure of peripheral nerves, neuromuscular junctions and muscles was investigated after 6 months of exposure to CS2.
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6157800 Vasilescu C, Florescu A: Clinical and electrophysiological studies of carbon disulphide polyneuropathy. J Neurol. 1980;224(1):59-70.


Association of the above findings with the significant electrophysiological changes, viz., decrease in the amplitude of sensory evoked potentials on stimulation of the digital fibres, mild slowing of sensory conduction velocity in the peripheral nerves, and decrease in the amplitude of evoked potentials in the distal muscles, suggest that the carbon disulphide polyneuropathy would be underlain by a primary distal axonopathy.
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865277 Laurman W, Wronska-Nofer T: [Effect of carbon disulfide on cholesterol content in rat tissue] . Med Pr. 1977;28(2):77-82.

The level of cholesterol in the blood, aorta wall, muscles, liver and adipose tissue was estimated after 4, 10 and 13 months of intoxication.
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18363127 Filosto M, Tentorio M, Broglio L, Buzio S, Lazzarini C, Pasolini MP, Cotelli MS, Scarpelli M, Mancuso M, Choub A, Padovani A: Disulfiram neuropathy: two cases of distal axonopathy. Clin Toxicol. 2008 Apr;46(4):314-6.


DISCUSSION The mechanisms by which disulfiram cause injury in human nerves are unclear, though may involve carbon disulfide.
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