Protein Information

Name Aldehyde dehydrogenases (protein family or complex)
Synonyms aldehyde dehydrogenase; aldehyde dehydrogenases

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
19922789 Moon KH, Lee YM, Song BJ: Inhibition of hepatic mitochondrial aldehyde dehydrogenase by carbon tetrachloride through JNK-mediated phosphorylation. Free Radic Biol Med. 2010 Feb 1;48(3):391-8. Epub 2009 Nov 14.
162(2,2,2,2) Details
19437487 Zhou P, Hohm S, Olusanya Y, Hess DA, Nolta J: Human progenitor cells with high aldehyde dehydrogenase activity efficiently engraft into damaged liver in a novel model. Hepatology. 2009 Jun;49(6):1992-2000.

We transplanted lineage-depleted human umbilical cord blood-derived cells with high aldehyde dehydrogenase activity (ALDH (hi) Lin (-)) into irradiated NOD/SCID/MPSVII mice followed by carbon tetrachloride administration to induced liver damage.
7(0,0,1,2) Details
19441727 Satanovskaia VI, Pron'ko PS, Gaishmanova AV, Miskevich DA: [Effects of panthenol and carnitine on aldehyde metabolic enzymes in rats with tetrachloromethane-induced liver injury]. Eksp Klin Farmakol. 2009 Mar-Apr;72(2):39-40.


Tetrachloromethane (2 g/kg, intragastric) produced a decrease in the activity of NAD- and NADH- dependent aldehyde dehydrogenases with high Km for aldehydes in rat liver.
1(0,0,0,1) Details
19895471 Kim BY, Cui ZG, Lee SR, Kim SJ, Kang HK, Lee YK, Park DB: Effects of Asparagus officinalis extracts on liver cell toxicity and ethanol metabolism. J Food Sci. 2009 Sep;74(7):H204-8.


Additionally, the activities of 2 key enzymes that metabolize ethanol, alcohol dehydrogenase and aldehyde dehydrogenase, were upregulated by more than 2-fold in response to treatment with the leaf- and shoot extracts.
1(0,0,0,1) Details