| Name | AT1 |
|---|---|
| Synonyms | AG2S; AT1; AGTR 1; AGTR1; AGTR1A; AGTR1B; AT1AR; AT1B… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16774739 | Nabeshima Y, Tazuma S, Kanno K, Hyogo H, Iwai M, Horiuchi M, Chayama K: Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis. Biochem Biophys Res Commun. 2006 Aug 4;346(3):658-64. Epub 2006 Jun 8. We recently showed that a lack of angiotensin (Ang) II type 1 (AT1) receptor activity reduces liver fibrosis. A comparison was made between AT2-receptor knockout (AT2KO) and wild type (WT) mice after 4 weeks of treatment with carbon tetrachloride (CCl4). |
2(0,0,0,2) | Details |
| 15244070 | Nie L, Imamura M, Itoh H, Ueno H: Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin II receptor blocker, on CCl4-induced liver fibrosis in rats. J UOEH. 2004 Jun 1;26(2):165-77. It has been shown that a (3--3-methyl-glutaryl coenzyme reductase inhibitor) enhances a suppressive effect of angiotensin II type 1 receptor (AT1-R) blocker (ARB) on injury-induced transforming growth factor (TGF)-beta expression in kidneys. In this study, we tested whether a combinatory use of a (pitavastatin) and an ARB (candesartan) may further inhibit liver fibrogenesis in carbon tetrachloride (CCl4)-treated rats. |
1(0,0,0,1) | Details |
| 19399400 | Zhu R, Yang L, Shen L, Ye J, Liu J, Hu S: ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene. J Huazhong Univ Sci Technolog Med Sci. 2009 Apr;29(2):177-81. Epub 2009 Apr 28. To investigate the effects of beta-elemene on the ANG II-AT1 receptor pathway in rats with liver fibrosis, a model of hepatic fibrosis was induced by hypodermical injection of carbon tetrachloride (CCl4) into Wistar male rats. beta-elemene was intraperitonealy administered into the rats for 8 weeks (0.1 mL/100 g body weight per day). |
33(0,1,1,3) | Details |
| 14761280 | Li X, Meng Y, Yang XS, Zhang ZS, Wu PS, Zou JL: [Perindopril attenuates the progression of CCl4-inducing rat hepatic fibrosis]. Zhonghua Gan Zang Bing Za Zhi. 2004 Jan;12(1):32-4. RT-PCR was utilized to detect gene expression of angiotensin II type 1 receptor (AT1 receptor) in the liver. |
4(0,0,0,4) | Details |
| 20044807 | Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Gines P, Bataller R: Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2010 Mar;51(3):942-52. Angiotensin type 1 (AT1) receptor blockers attenuate liver fibrogenesis, yet their efficacy in reversing advanced fibrosis is unknown. Rats with advanced liver fibrosis due to prolonged bile duct ligation or carbon tetrachloride administration were treated with daily doses of saline, losartan-M6PHSA, M6PHSA or oral losartan during 3 days. |
3(0,0,0,3) | Details |