Protein Information

Name interferon (protein family or complex)
Synonyms Interferon

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
15583823 Aziz TA, Aziz MA, Fouad HH, Rashed LA, Salama H, Abd-Alla S, Wehab MA, Ahmed T: Interferon-alpha gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats. Int J Mol Med. 2005 Jan;15(1):21-6.

Retrovirus-mediated interferon alpha (IFN-alpha) gene transfer was evaluated with regard to its possible protective effects against aflatoxin B1 (AFB1)-initiated and carbon tetrachloride (CCl4)-promoted hepatic carcinogenesis in rats.
37(0,1,2,2) Details
18007553 Alvarez GC, Madrid-Marina V, Jimenez-Mendez R, Buitimea AL, Roman MB, Cortez-Gomez R, Esparza JR, Rodriguez-Fragoso L: Combined therapy with danazol, pegilated interferon, and ribavirin improves thrombocytopenia and liver injury in rats with fibrosis. Ann Hepatol. 2007 Oct-Dec;6(4):233-41.

3(0,0,0,3) Details
18544128 Tutau F, Rodriguez-Ortigosa C, Puche JE, Juanarena N, Monreal I, Garcia Fernandez M, Clavijo E, Castilla A, Castilla-Cortazar I: Enhanced actions of insulin-like growth factor-I and interferon-alpha co-administration in experimental cirrhosis. Liver Int. 2009 Jan;29(1):37-46. Epub 2008 Jun 9.

2(0,0,0,2) Details
15308637 Barnes BJ, Richards J, Mancl M, Hanash S, Beretta L, Pitha PM: Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection. J Biol Chem. 2004 Oct 22;279(43):45194-207. Epub 2004 Aug 11.


The interferon regulatory factors (IRF) are transcriptional mediators of cellular response to viral invasion that play a critical role in the innate antiviral defense.
2(0,0,0,2) Details
19001734 Yang HX, Yi YR: [Curative effect of interferon-alpha on rat liver fibrosis induced by CCl4]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Oct;33(10):919-25.

2(0,0,0,2) Details
15123359 Batusic DS, Armbrust T, Saile B, Ramadori G: Induction of Mx-2 in rat liver by toxic injury. J Hepatol. 2004 Mar;40(3):446-53.


BACKGROUND/AIMS: Mx proteins are supposed to be strictly regulated by viruses or interferon-alpha (IFN-alpha).
1(0,0,0,1) Details
15383179 Phaneuf D, Moscioni AD, LeClair C, Raper SE, Wilson JM: Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration. DNA Cell Biol. 2004 Sep;23(9):592-603.

To induce liver regeneration, mice were injected with the hepatotoxin carbon tetrachloride.
A similar reduction in hepatocyte regeneration was observed in HGF (ex.5.flox) mice carrying the cre transgene under the control of the interferon-inducible (pI:pC) Mx1 promoter, as an alternative strategy to ablate the HGF/SF gene in liver.
1(0,0,0,1) Details
17132917 Lee KS: [Hepatic fibrogenesis] . Korean J Gastroenterol. 2006 Nov;48(5):297-305.


Many kinds of factors such as oxidative stress, acetaldehyde, ascorbic acid, transforming growth factor-beta (TGF-beta) and carbon tetrachloride (CCl4) have been reported to activate HSC and stimulate collagen gene expression.
0(0,0,0,0) Details
16027843 Filimonov PN, Sukhenko TG, Gavrilova NI, Shkurupii VA: Effect of IFN-alpha on CC1 4-induced fibrosis of the liver and immune status in mice of different age. Bull Exp Biol Med. 2005 Mar;139(3):324-7.


In young, adult, and old mice fibrosis was induced by administration of CC1 (4) and treated with IFN-alpha; liver fibrosis was evaluated by morphometry of argyrophilic fibers, immune status by the splenocyte proliferative response. minimum immunosuppression and maximum antifibrotic effect were observed in young mice, while adult mice exhibited pronounced immunotoxicity and weak response to interferon therapy.
1(0,0,0,1) Details