| Name | chemokine |
|---|---|
| Synonyms | CXCL12; Chemokine; Chemokine ligand 12; PBSF; Pre B cell growth stimulating factor; SCYB12; SDF 1 alpha; SDF 1 beta… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18085377 | Yoneyama H, Kai Y, Koyama J, Suzuki K, Kawachi H, Narumi S, Ichida T: Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury. Med Mol Morphol. 2007 Dec;40(4):191-7. Epub 2007 Dec 21. We report here that the chemokine CXCL10 regulates hepatic tissue remodeling in a carbon tetrachloride (CCl (4))-induced acute liver injury in mice. |
6(0,0,1,1) | Details |
| 19344719 | Wasmuth HE, Lammert F, Zaldivar MM, Weiskirchen R, Hellerbrand C, Scholten D, Berres ML, Zimmermann H, Streetz KL, Tacke F, Hillebrandt S, Schmitz P, Keppeler H, Berg T, Dahl E, Gassler N, Friedman SL, Trautwein C: Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. Gastroenterology. 2009 Jul;137(1):309-19 Chemokines are ubiquitous chemotactic molecules that mediate many acute and chronic inflammatory conditions, and CXC chemokine genes colocalize with a locus previously shown to include fibrogenic genes. |
4(0,0,0,4) | Details |
| 18421012 | Kalin TV, Meliton L, Meliton AY, Zhu X, Whitsett JA, Kalinichenko VV: Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene. Am J Respir Cell Mol Biol. 2008 Oct;39(4):390-9. Epub 2008 Apr 17. Pulmonary inflammation in Foxf1 (+/-) mice was associated with diminished expression of Foxf1, increased mast cell tryptase, and increased expression of CXCL12, the latter being essential for mast cell migration and chemotaxis. |
3(0,0,0,3) | Details |
| 19913046 | Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY: Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):318-25. Epub 2009 Nov 11. Serum liver enzyme levels, histology, expression of antioxidant enzymes, and several cytokines/chemokines were subsequently evaluated. |
2(0,0,0,2) | Details |
| 19496198 | Jin SZ, Meng XW, Han MZ, Sun X, Sun LY, Liu BR: Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure. 319.e1-3. Epub 2009 Apr 1. The labeled cells were subsequently infused into the caudal veins of BALB/c mice with hepatic injury induced by carbon tetrachloride and 2-acetylaminofluorene. |
2(0,0,0,2) | Details |
| 17125873 | Zamara E, Galastri S, Aleffi S, Petrai I, Aragno M, Mastrocola R, Novo E, Bertolani C, Milani S, Vizzutti F, Vercelli A, Pinzani M, Laffi G, LaVilla G, Parola M, Marra F: Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice. J Hepatol. 2007 Feb;46(2):230-8. Epub 2006 Oct 23. BACKGROUND/AIMS: Administration of carbon tetrachloride determines liver injury, inflammation and oxidative stress, but the molecular mechanisms of damage are only partially understood. In this study, we investigated the development of acute toxic damage in mice lacking monocyte chemoattractant protein-1 (MCP-1), a chemokine which recruits monocytes and activated lymphocytes. |
2(0,0,0,2) | Details |
| 16118408 | Stefanovic L, Brenner DA, Stefanovic B: Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med. 2005 Sep;230(8):573-86. |
2(0,0,0,2) | Details |
| 19443073 | Lafdil F, Chobert MN, Deveaux V, Zafrani ES, Mavier P, Nakano T, Laperche Y, Brouillet A: Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice. J Hepatol. 2009 Jul;51(1):55-66. Epub 2009 Apr 22. METHODS: Toxic hepatitis was induced by a single carbon tetrachloride injection in Gas6 deficient (Gas6 (-/-)) mice and liver recovery was compared with wild-type animals. Gas6-deficiency, by limiting cytokine/chemokine release, prevents hepatocyte proliferation, recruitment of circulating monocytes and accumulation of myofibroblasts in healing areas. |
2(0,0,0,2) | Details |
| 17105404 | Jung YJ, Ryu KH, Cho SJ, Woo SY, Seoh JY, Chun CH, Yoo K, Moon IH, Han HS: Syngenic bone marrow cells restore hepatic function in carbon tetrachloride-induced mouse liver injury. Stem Cells Dev. 2006 Oct;15(5):687-95. Stem cell homing to the injured tissue is regulated through stromal cell derived factor-1 (SDF-1) and its receptor CXCR4. |
1(0,0,0,1) | Details |
| 18992833 | Ju SY, Cho KA, Cho SJ, Jung YJ, Woo SY, Seoh JY, Han HS, Ryu KH: Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver. Cell Biol Int. 2009 Jan;33(1):31-5. Epub 2008 Oct 22. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF-1alpha, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl (4) damaged liver. |
1(0,0,0,1) | Details |
| 15805055 | Mehendale HM: Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol. 2005;33(1):41-51. Extensive evidence in rodent models using structurally and mechanistically diverse hepatotoxicants such as carbon tetrachloride (CCl4), chloroform (CHCl3), thioacetamide (TA), trichloroethylene (TCE), and allyl (AA) have demonstrated that tissue repair plays a critical role in determining the final outcome of toxicity, i.e., recovery from injury and survival or progression of injury leading to liver failure and death. Tissue repair is a complex process governed by intricate cellular signaling involving a number of chemokines, cytokines, growth factors, and nuclear receptors leading to promitogenic gene expression and cell division. |
1(0,0,0,1) | Details |
| 17714472 | Asano Y, Iimuro Y, Son G, Hirano T, Fujimoto J: Hepatocyte growth factor promotes remodeling of murine liver fibrosis, accelerating recruitment of bone marrow-derived cells into the liver. Hepatol Res. 2007 Dec;37(12):1080-94. Epub 2007 Aug 20. Expression of stromal cell-derived factor (SDF)-1 in the liver was upregulated around the central veins, especially in the HGF gene-transferred animals, recruiting chemokine (C-X-C motif) receptor (CXCR) 4-positive cells in this area. Methods: C57BL/6 J mice were treated with carbon tetrachloride (CCl (4)) for 10 weeks. |
1(0,0,0,1) | Details |
| 17696803 | Ramaiah SK, Rittling S: Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury. Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):519-26. In the liver, it has been reported that hepatic Kupffer cells secrete OPN facilitating macrophage infiltration in necrotic areas following carbon tetrachloride liver toxicity. Recent work has underlined the importance of OPN as a pivotal cytokine/chemokine in the generated hepatic neutrophil response during early phase alcoholic liver injury. |
1(0,0,0,1) | Details |