| Name | bcl 2 |
|---|---|
| Synonyms | Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19808650 | Mitchell C, Robin MA, Mayeuf A, Mahrouf-Yorgov M, Mansouri A, Hamard M, Couton D, Fromenty B, Gilgenkrantz H: Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice. Am J Pathol. 2009 Nov;175(5):1929-37. Epub 2009 Oct 1. Analyses of mitochondrial DNA, respiratory chain complexes, and lipid peroxidation showed that Bcl-2 transgenic animals were protected against mitochondrial dysfunction and oxidative stress resulting from carbon tetrachloride injury. |
39(0,1,2,4) | Details |
| 16640835 | Lee TY, Chang HH, Wang GJ, Chiu JH, Yang YY, Lin HC: -soluble extract of Salvia miltiorrhiza ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. J Pharm Pharmacol. 2006 May;58(5):659-65. Hepatic cytosolic Bax, Bcl-2, cytochrome c, and calpain-mu expressions were measured by Western blot analysis. |
2(0,0,0,2) | Details |
| 16212920 | Pan H, Hong F, Radaeva S, Gao B: Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol. 2004 Feb;1(1):43-9. In the present paper, we demonstrate that hydrodynamic gene delivery of IL-22 cDNA driven either by a liver-specific albumin promoter or a human cytomegalovirus (CMV) promoter results in IL-22 protein expression, STAT3 activation, and expression of several anti-apoptotic proteins, including Bcl-xL, Bcl-2, and Mcl-1 in the liver. |
2(0,0,0,2) | Details |
| 19786014 | Shi H, Dong L, Bai Y, Zhao J, Zhang Y, Zhang L: against carbon tetrachloride-induced liver fibrosis in rats. Eur J Pharmacol. 2009 Nov 25;623(1-3):119-24. Epub 2009 Sep 26. As compared with the CGA-treated group, the expression of bcl-2, vascular endothelial growth factor (VEGF), and transforming growth factor (TGF-beta1) mRNA was increased in CCl (4) group, whereas Bax mRNA expression decreased. |
2(0,0,0,2) | Details |
| 20106566 | Shi H, Dong L, Zhang Y, Bai Y, Zhao J, Zhang L: Protective effect of a coffee preparation (Nescafe pure (R)) against carbon tetrachloride-induced liver fibrosis in rats. Clin Nutr. 2010 Jan 26. The mRNA expression of collagen I, collagen III, bcl-2, vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta1) were markedly increased by CCl (4) treatment but suppressed by a coffee preparation treatment. |
2(0,0,0,2) | Details |
| 16542346 | Tessitore L, Bollito E: Early induction of TGF-beta1 through a fasting-re-feeding regimen promotes liver carcinogenesis by a sub-initiating dose of diethylnitrosamine. Cell Prolif. 2006 Apr;39(2):105-16. All three groups were then subjected to the 2-acetylaminofluorene/carbon tetrachloride promoting regimen. Fasting induced moderate apoptosis in liver tissue, as evidenced by increased levels of transforming growth factor-beta1 (TGF-beta1) and Bax proteins and by a dramatic drop in the level of Bcl-2. |
1(0,0,0,1) | Details |
| 19114984 | Liu Y, Lui EL, Friedman SL, Li L, Ye T, Chen Y, Poon RT, Wo J, Kok TW, Fan ST: PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Lab Invest. 2009 Feb;89(2):209-21. Epub 2008 Dec 29. PTK/ZK-induced apoptosis of HSCs, which was correlated with increased caspase-3 activation and suppressed Bcl-2 expression. In a murine fibrotic liver, PTK/ZK attenuated collagen deposition and alpha-SMA expression in carbon tetrachloride-induced fibrosis in both a 'prevention' and 'treatment' dosing scheme. |
1(0,0,0,1) | Details |
| 15122762 | Radaeva S, Sun R, Pan HN, Hong F, Gao B: Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology. 2004 May;39(5):1332-42. IL-22 messenger RNA and protein expression are significantly elevated in T cell-mediated hepatitis induced by concanavalin A (ConA) but are less extensively elevated in the carbon tetrachloride-induced liver injury model. Stable overexpression of IL-22 in HepG2 cells constitutively activates STAT3 and induces expression of a variety of antiapoptotic (e.g., Bcl-2, Bcl-xL, Mcl-1) and mitogenic (e.g., c-myc, cyclin D1, Rb2, CDK4) proteins. |
1(0,0,0,1) | Details |
| 17761835 | Ikeda H, Kume Y, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Arai M, Arai C, Omata M, Fujiwara K, Yatomi Y: Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G911-7. Epub 2007 Aug 30. In cultured rat hepatocytes in serum-free condition, HA-1077 reduced apoptosis evaluated by quantitative determination of cytoplasmic histone-associated DNA oligonucleosome fragments with the reduction of caspase-3 activity and the enhancement of Bcl-2 expression. |
1(0,0,0,1) | Details |
| 16426832 | Zhang S, Ji G, Liu J: Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. J Nutr Biochem. 2006 Jul;17(7):485-91. Epub 2005 Oct 10. And the expression of bcl-2 mRNA was down-regulated after puerarin administration. In the present study, we investigated the effects of puerarin on liver fibrosis in Wistar rats induced by plus carbon tetrachloride administration. |
1(0,0,0,1) | Details |
| 19674103 | Guo CJ, Pan Q, Cheng T, Jiang B, Chen GY, Li DG: Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. FEBS J. 2009 Sep;276(18):5163-76. Epub 2009 Aug 10. Furthermore, mitochondrial integrity, based on highly upregulated Bcl-2 and downregulated caspase-9, was confirmed in HSCs and fibrotic livers by immnofluorescence assay, quantitative RT-PCR, and western blot analysis. |
1(0,0,0,1) | Details |