| Name | ERK1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17156884 | Fernandez-Varo G, Morales-Ruiz M, Ros J, Tugues S, Munoz-Luque J, Casals G, Arroyo V, Rodes J, Jimenez W: Impaired extracellular matrix degradation in aortic vessels of cirrhotic rats. J Hepatol. 2007 Mar;46(3):440-6. Epub 2006 Nov 13. Phosphorylated p38 MAPK and ERK1/2 were used to evaluate the activation of cell MAPK signaling pathways. |
4(0,0,0,4) | Details |
| 17482686 | Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, Matsuo O: Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes. Biochim Biophys Acta. 2007 Jun;1773(6):718-27. Epub 2007 Apr 1. Plasmin also triggered phosphorylation of ERK1/2 without cell detachment. |
3(0,0,0,3) | Details |
| 17298859 | Sawant SP, Dnyanmote AV, Mehendale HM: Mechanisms of inhibited liver tissue repair in toxicant challenged type 2 diabetic rats. Toxicology. 2007 Apr 11;232(3):200-15. Epub 2007 Jan 14. In CCl (4)-treated non-diabetic (non-DB) rats, increased IL-6 levels, sustained activation of extracellular regulated kinases 1/2 (ERK1/2) MAPK, and sustained phosphorylation of retinoblastoma protein (p-pRB) via cyclin D1/cyclin-dependent kinase (cdk) 4 and cyclin D1/cdk6 complexes stimulated G (0)/G (1) to S-phase transition of liver cells. |
2(0,0,0,2) | Details |
| 17032414 | Qiang H, Lin Y, Zhang X, Zeng X, Shi J, Chen YX, Yang MF, Han ZG, Xie WF: Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis. Liver Int. 2006 Nov;26(9):1126-37. METHODS: Hepatic fibrosis was induced by intraperitoneal injection of dimethylnitrosamine or carbon tetrachloride (CCl (4)) injection subcutaneously in rats, and identification of the hepatic fibrosis related genes with cDNA microarray was performed. Transfection of siRNA targeting ERK1 mRNA (siERK1) into HSC led to a 66% and 72% reduction of ERK1 mRNA and protein expression, respectively. |
2(0,0,0,2) | Details |
| 17285312 | Iida C, Fujii K, Kishioka T, Nagae R, Onishi Y, Ichi I, Kojo S: Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat liver. Arch Toxicol. 2007 Jul;81(7):489-93. Epub 2007 Feb 7. Phosphorylated JNK (c-Jun NH (2)-terminal kinase) and phospho-ERK1/2 (extracellular signal-regulated kinase1/2) were significantly increased transiently 1-3 h after treatment with CCl (4), while phosphorylated p38 decreased significantly 1-24 h after CCl (4) treatment. |
1(0,0,0,1) | Details |
| 19650157 | Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA: Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep;50(3):929-38. HSCs express the Ang (1-7) receptor Mas and Ang (1-7) inhibited Ang II-induced phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 in cultured HSCs. Ace2 KO mice showed increased liver fibrosis following bile duct ligation for 21 days or chronic carbon tetrachloride (CCl (4)) treatment. |
1(0,0,0,1) | Details |
| 15983038 | Nieto N, Cederbaum AI: blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. J Biol Chem. 2005 Sep 2;280(35):30963-74. Epub 2005 Jun 27. To study the anti-fibrogenic mechanisms of transgenic mice harboring the -17 kb to +54 bp of the collagen alpha2 (I) promoter (COL1A2) cloned upstream from the beta-gal reporter gene were injected with carbon tetrachloride (CCl4) to induce fibrosis and coadministered either or saline. blocked TGFbeta induction of the -378 bp region of the COL1A2 promoter and prevented the phosphorylation of extracellular signal-regulated kinase 1/2 and the binding of Sp1 to the TGFbeta-responsive element. |
1(0,0,0,1) | Details |
| 17133482 | Smart DE, Green K, Oakley F, Weitzman JB, Yaniv M, Reynolds G, Mann J, Millward-Sadler H, Mann DA: JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation. Hepatology. 2006 Dec;44(6):1432-40. The junD-/- mice were protected from carbon tetrachloride-induced fibrosis. In examining the signal transduction mechanisms that regulate JunD-dependent TIMP-1 expression, we found a role for phosphorylation of the Ser100 residue of JunD but ruled out JNK as a mediator of this event, suggesting ERK1/2 is utilized. |
1(0,0,0,1) | Details |
| 17292878 | Park EJ, Zhao YZ, Kim YC, Sohn DH: Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts. Eur J Pharmacol. 2007 Mar 22;559(2-3):115-23. Epub 2007 Jan 23. Bakuchiol treatment stimulated the activation of extracellular signal-regulated kinase 1/2 (ERK), c-Jun NH2-terminal protein kinase (JNK), and p38 mitogen-activated protein kinases (MAPK) in vitro. |
1(0,0,0,1) | Details |
| 19066852 | Iida C, Fujii K, Koga E, Washino Y, Kitamura Y, Ichi I, Abe K, Matsura T, Kojo S: Effect of on carbon tetrachloride intoxication in the rat liver. Arch Toxicol. 2009 May;83(5):477-83. Epub 2008 Dec 10. The activation of JNK, ERK1/2 and p38 MAPK took place 1.5 h after CCl (4) administration. |
1(0,0,0,1) | Details |